Lumefantrine Pharmacology

Lumefantrine

About Lumefantrine

Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. Lumefantrine is a racemic mixture of a synthetic fluorine derivative and is structurally related to quinine, mefloquine, and halofantrine.

Mechanism of Action of Lumefantrine

It interferes with the conversion of heme, the toxic intermediate step produced during hemoglobin break-down, to non-toxic hemozoin. Accumulation of heme and free radicals results in parasite death.

Pharmacokinets of Lumefantrine

1.Absorption:Food increases absorption
2.Distribution: Protein binding 99.7% bound
3.Metabolism:Extensively metabolized in the liver primarily by cytochrome P450 3A4. The major metabolite found in plasma is desbutyl-lumefantrine.

Onset of Action for Lumefantrine

N/A

Duration of Action for Lumefantrine

N/A

Half Life of Lumefantrine

~4.5 days

Side Effects of Lumefantrine

N/A

Contra-indications of Lumefantrine

N/A

Special Precautions while taking Lumefantrine

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Lumefantrine

1.Lumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas.
2.May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.

Interactions for Lumefantrine

N/A

Typical Dosage for Lumefantrine

N/A

Schedule of Lumefantrine

N/A

Storage Requirements for Lumefantrine

N/A

Effects of Missed Dosage of Lumefantrine

N/A

Effects of Overdose of Lumefantrine

N/A

Home Delivery for Lumefantrine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lumefantrine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lumefantrine and other medicines and health products. Home delivery services for lumefantrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lumefantrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lumefantrine before they complete the sale. You can get this information while placing the order for lumefantrine with the pharmacy.

Lumefantrine is a generic medicine name and there are several brands available for it. Some of the brands for lumefantrine might be better known than lumefantrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lumefantrine in stock, you can ask for one of the branded alternatives for lumefantrine.