Levosulpiride Pharmacology


About Levosulpiride
Antipsychotic and prokinetic agent. It is the (S)-enantiomer of sulpiride.
Selective antagonist of central dopamine (D-2, D-3 and D-4) receptors.
Mechanism of Action of Levosulpiride
Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.
Pharmacokinets of Levosulpiride
Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Metabolism: Hepatic.
Excretion: Mainly via urine
Onset of Action for Levosulpiride
Duration of Action for Levosulpiride
Half Life of Levosulpiride
9.7 hr (oral); 4.3 hr (IV).
Side Effects of Levosulpiride
4.Changes in libido
5.Potentially Fatal: Neuroleptic malignant syndrome.
Contra-indications of Levosulpiride
3.Manic states
5.Mammary dysplasia
6.Malignant mastopathies
7.Cardiac impairment
8.GI bleeding, mechanical obstruction or perforation.
Special Precautions while taking Levosulpiride
1.May impair ability to drive or operate machinery
2.Avoid alcohol.
Pregnancy Related Information
Use with caution
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Levosulpiride
2.Dyspeptic syndrome
3.Functional dyspepsia
5.Irritable bowel syndrome
6.Cytotoxic-induced nausea and vomiting
7.Vasomotor headache
Interactions for Levosulpiride
1.Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids.
2.Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics.
3.Avoid alcohol.
Typical Dosage for Levosulpiride
25-200 mg/day in divided doses.
Schedule of Levosulpiride
Storage Requirements for Levosulpiride
Oral: Store at 15-30?C (59-86?F). Parenteral: Store at 15-30?C (59-86?F).
Effects of Missed Dosage of Levosulpiride
Effects of Overdose of Levosulpiride

Home Delivery for Levosulpiride in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levosulpiride.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levosulpiride and other medicines and health products. Home delivery services for levosulpiride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levosulpiride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levosulpiride before they complete the sale. You can get this information while placing the order for levosulpiride with the pharmacy.

Levosulpiride is a generic medicine name and there are several brands available for it. Some of the brands for levosulpiride might be better known than levosulpiride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levosulpiride in stock, you can ask for one of the branded alternatives for levosulpiride.