Mecobalamin + Pregabalin Pharmacology

Mecobalamin + Pregabalin

About Mecobalamin + Pregabalin
N/A
Mechanism of Action of Mecobalamin + Pregabalin
N/A
Pharmacokinets of Mecobalamin + Pregabalin
N/A
Onset of Action for Mecobalamin + Pregabalin
N/A
Duration of Action for Mecobalamin + Pregabalin
N/A
Half Life of Mecobalamin + Pregabalin
N/A
Side Effects of Mecobalamin + Pregabalin
N/A
Contra-indications of Mecobalamin + Pregabalin
N/A
Special Precautions while taking Mecobalamin + Pregabalin
N/A
Pregnancy Related Information
Contra indicated
Old Age Related Information
Dosage adjustment may be needed
Breast Feeding Related Information
Contra indicated
Children Related Information
Not recommended
Indications for Mecobalamin + Pregabalin
Postherpetic neuralgia.
Interactions for Mecobalamin + Pregabalin
N/A
Typical Dosage for Mecobalamin + Pregabalin
N/A
Schedule of Mecobalamin + Pregabalin
N/A
Storage Requirements for Mecobalamin + Pregabalin
N/A
Effects of Missed Dosage of Mecobalamin + Pregabalin
N/A
Effects of Overdose of Mecobalamin + Pregabalin
N/A

Mecobalamin

About Mecobalamin
Water soluble, Form of Vitamin B12
Mechanism of Action of Mecobalamin
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Pharmacokinets of Mecobalamin
Absorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for Mecobalamin
N/A
Duration of Action for Mecobalamin
N/A
Half Life of Mecobalamin
N/A
Side Effects of Mecobalamin
1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of Mecobalamin
N/A
Special Precautions while taking Mecobalamin
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Mecobalamin
1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin
1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for Mecobalamin
Peripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk

Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Schedule of Mecobalamin
N/A
Storage Requirements for Mecobalamin
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.


Effects of Missed Dosage of Mecobalamin
N/A
Effects of Overdose of Mecobalamin
N/A

Pregabalin

About Pregabalin
A GABA agonist, Anticonvulsant.
Mechanism of Action of Pregabalin
Pregabalin is a GABA neurotransmitter analog. It produces its action by modulating calcium channels and also reduces the release of neurotransmitters such as Glutamate, Norepinephrine, Serotonin, Dopamine and Substance P.
Pharmacokinets of Pregabalin
Absorption: Pregabalin is rapidly absorbed after oral doses.Pregabalin is not bound to plasma proteins and undergoes negligible metabolism.Excretion: It is excreted mainly in urine.
Onset of Action for Pregabalin
N/A
Duration of Action for Pregabalin
N/A
Half Life of Pregabalin
6-7 hours
Side Effects of Pregabalin
1.Dizziness
2.Somnolence
3.Blurred vision
4.Diplopia
5.Increased appetite
6.Weight gain
7.Dry mouth
8.Constipation
9.Vomiting
10.Flatulence
11.Euphoria
12.Confusion
13.Reduced libido
14.Erectile dysfunction
15.Irritability
16.Vertigo
17.Ataxia
18.Tremor
19.Dysarthria
20.Paraesthesia
21.Fatigue
22.Oedema
23.Disturbances of attention, memory, coordination, and gait also occur frequently
Contra-indications of Pregabalin
1.Hypersensitivity to Pregabalin
Special Precautions while taking Pregabalin
1.Renal impairment
2.Driving vehicles, operating machines and people involving any other dangerous activities
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Pregabalin
1.Epilepsy
2.Generalised anxiety disorder
3.Neuropathic pain
Interactions for Pregabalin
N/A
Typical Dosage for Pregabalin
150- 300mg / day in 2 divided doses
Schedule of Pregabalin
N/A
Storage Requirements for Pregabalin
Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Pregabalin
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose
Effects of Overdose of Pregabalin
Give supportive measures and symptomatic treatment.

Home Delivery for Mecobalamin + Pregabalin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mecobalamin + pregabalin and other medicines and health products. Home delivery services for mecobalamin + pregabalin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mecobalamin + pregabalin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mecobalamin + pregabalin before they complete the sale. You can get this information while placing the order for mecobalamin + pregabalin with the pharmacy.

Mecobalamin + Pregabalin is a generic medicine name and there are several brands available for it. Some of the brands for mecobalamin + pregabalin might be better known than mecobalamin + pregabalin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mecobalamin + pregabalin in stock, you can ask for one of the branded alternatives for mecobalamin + pregabalin.