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- Pharmacology For Ampicillin + Sulbactam Sodium
Ampicillin + Sulbactam Sodium Pharmacology
Ampicillin + Sulbactam SodiumAbout Ampicillin + Sulbactam SodiumN/AMechanism of Action of Ampicillin + Sulbactam SodiumN/APharmacokinets of Ampicillin + Sulbactam SodiumN/AOnset of Action for Ampicillin + Sulbactam SodiumN/ADuration of Action for Ampicillin + Sulbactam SodiumN/AHalf Life of Ampicillin + Sulbactam SodiumN/ASide Effects of Ampicillin + Sulbactam SodiumN/AContra-indications of Ampicillin + Sulbactam SodiumN/ASpecial Precautions while taking Ampicillin + Sulbactam SodiumN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Ampicillin + Sulbactam SodiumAmpicillin has a narrow spectrum of activity and is mainly active against Gram positive bacilli, both gram positive and Gram negative cocci and spirochaetes. Sulbactam is a beta-lactamase enzyme inhibitor. By inhibiting this enzyme it prevent the breakdown of Ampicillin and help Ampicillin to kill the bacteria. The combination generic is used to treat infections caused by bacteria resistant to beta lactam antibiotics.
1.Skin and Skin Structure Infections caused by beta-lactamase producing bacteria
2.Intra abdominal infections caused by beta-lactamase producing bacteria
3.Gynaecologycal infections caused by beta-lactamase producing bacteria
Interactions for Ampicillin + Sulbactam SodiumN/ATypical Dosage for Ampicillin + Sulbactam SodiumAdult (IM or IV infusion): 1.5g - 3g/ day in 3 - 4 divided dose depending on the severity of infection. (Ampicillin 1 g + Sulbactum 0.5 g or Ampicillin 2 g + Sulbactum 1 g )
Children: Ampicillin100 mg / day +sulbactam50 mg/day in 3 - 4 divided dose depending on the severity of infection
Schedule of Ampicillin + Sulbactam SodiumN/AStorage Requirements for Ampicillin + Sulbactam SodiumN/AEffects of Missed Dosage of Ampicillin + Sulbactam SodiumN/AEffects of Overdose of Ampicillin + Sulbactam SodiumN/A
AmpicillinAbout AmpicillinSemisynthetic Broad spectrum beta-lactam antibiotic, Aminobenzylpenicillin AntibioticMechanism of Action of AmpicillinAmpicillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Ampicillin is active against both gram positive and gram negative organism.Pharmacokinets of AmpicillinAbsorption .It is readily but incompletely absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through bile and small amount excreted through urine and breast milk.Onset of Action for Ampicillin30 minutesDuration of Action for Ampicillin6 - 8 hoursHalf Life of Ampicillin90 minutesSide Effects of Ampicillin1.Nausea
Contra-indications of Ampicillin1.Hypersensitivity to PenicillinSpecial Precautions while taking Ampicillin1.Mononucleosis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Ampicillin1.Urinary tract infections
5. Respiratory tract infections
7.Soft tissue infections
11.Biliary tract nfections
Interactions for AmpicillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Allopurinol: Increases risk of ampicillin induced skin rash.
Beta blockers: Oral penicillin like ampicillin may reduce bio-availability of atenolol. Also they may potentiate anaphylatic reactions with penicillin.
Probenecid: Increases blood levels.
Erythromycin, Tetracycline: Reduce efficacy.
Clavulinic Acid: Synergy.
Food: Interferes with absorption.Typical Dosage for AmpicillinADULT
Bacterial infections: 250 - 500 mg four times a day depending on the severity of infection
Typhoid and paratyphoid fever: 1 - 2 g four times daily
Bacterial infections: 125 - 250 mg four times a day depending on the severity of infection
.Schedule of AmpicillinHStorage Requirements for AmpicillinStore the drug at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of AmpicillinTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and continue the regular schedule. Do not double the dose.Effects of Overdose of AmpicillinGive supportive measures and symptomatic treatment. Absorption of the drug can be reduced by administration of activated charcoal.
Sulbactam SodiumAbout Sulbactam SodiumAn irreversible ?-lactamase inhibitor, To increase the antibacterial activity of penicillins and cephalosporins against ?-lactamase?producing organisms.Mechanism of Action of Sulbactam SodiumSulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Amoxycillin.
It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.
Pharmacokinets of Sulbactam SodiumN/AOnset of Action for Sulbactam SodiumN/ADuration of Action for Sulbactam SodiumN/AHalf Life of Sulbactam SodiumN/ASide Effects of Sulbactam Sodium1.Injection site reactions
6.Elevated liver enzymes
Contra-indications of Sulbactam SodiumHypersensitivity to SulbactamSpecial Precautions while taking Sulbactam SodiumPatient hypersensitive to CephalosporinPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Sulbactam Sodium1.Skin infections
2.Intra abdominal infectionS
Interactions for Sulbactam SodiumN/ATypical Dosage for Sulbactam SodiumAdults:
IM or IV: 1.5 - 3g every 6 hours; dose is depending on creatinine clearance
Schedule of Sulbactam SodiumN/AStorage Requirements for Sulbactam SodiumN/AEffects of Missed Dosage of Sulbactam SodiumN/AEffects of Overdose of Sulbactam SodiumN/A
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