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- Pharmacology For Azithromycin + Ambroxol
Azithromycin + Ambroxol Pharmacology
Azithromycin + Ambroxol
About Azithromycin + AmbroxolN/AMechanism of Action of Azithromycin + AmbroxolN/APharmacokinets of Azithromycin + AmbroxolN/AOnset of Action for Azithromycin + AmbroxolN/ADuration of Action for Azithromycin + AmbroxolN/AHalf Life of Azithromycin + AmbroxolN/ASide Effects of Azithromycin + AmbroxolN/AContra-indications of Azithromycin + AmbroxolN/ASpecial Precautions while taking Azithromycin + AmbroxolN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Azithromycin + AmbroxolUpper Respiratory Tract Infections:
1.Pharyngitis/Tonsillitis
2.Acute Bacterial Sinusitis
3.Otitis Media
Lower Respiratory Tract Infections:
1.Acute Bacterial Exacerbations Of Chronic Obstructive Pulmonary Disease
2.Community-Acquired Pneumonia
Interactions for Azithromycin + AmbroxolN/ATypical Dosage for Azithromycin + Ambroxol1.Community-Acquired Pneumonia, Pharyngitis/Tonsillitis:
Day 1: 500mg as a single dose
Day 2-5: 250mg once daily
2.Acute bacterial exacerbations of Chronic Obstructive Pulmonary Disease:
500mg QD x 3 days
or
Day 1: 500mg as a single dose
Day 2-5: 250mg once daily
3.Acute bacterial sinusitis; 500mg QD x 3 days
Schedule of Azithromycin + AmbroxolN/AStorage Requirements for Azithromycin + AmbroxolN/AEffects of Missed Dosage of Azithromycin + AmbroxolN/AEffects of Overdose of Azithromycin + AmbroxolN/AAzithromycin
About AzithromycinAn Azalide, macrolide antibiotic.
Mechanism of Action of AzithromycinAzithromycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Azithromycin is active against both gram positive and gram negative aerobic and anaerobic bacteriaPharmacokinets of AzithromycinAbsorption: Azithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is not metabolized in the body. Excretion: It is primarily excreted through bile and a very small amount excreted through urine.Onset of Action for Azithromycin1-2 hours.Duration of Action for AzithromycinN/AHalf Life of Azithromycin68 hourSide Effects of Azithromycin1. Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Angioedema
6.Rash
7.Urticaria
8.Headache
9.Dizziness
10.Fever
11.Cholestatic jaundice
12.Hearing disturbances
13.Vertigo
Contra-indications of Azithromycin1.Hypersensitivity to Azithromycin and other macrolideSpecial Precautions while taking Azithromycin1.Renal impairment
2.Hepatic dysfunction
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with cautionIndications for Azithromycin1.Pneumonia
2.Tonsilitis
3.Pharyngitis
4.Sinusitis
5.Urethritis
6.Cervicitis
7.SABE
8.Trachoma
9.Prevention of disseminated Mycobacterium avium complex infection
10.Otitis media
11.Chancroid
12..Acne
13.Urogenital infection
14.Skin and soft tissue infections
15.Toxoplasmosis
Interactions for AzithromycinAluminium & Magnesium containing Antacids: Decrease peak serum levels.
Theophylline: Serum concentration of Theophylline increased.
Warfarin: Anticoagulant effects enhanced.
Digoxin & Cyclosporine: Increase in their serum concentration.
Carbamazepine: Toxicity occurs which may require hospitalization.
Triazolam: Increases serum levels of Triazolam leading to toxicity.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Food: Absorption reduced by as much as 52% (should be taken 1 hr before or 2 hrs after meal).
Typical Dosage for AzithromycinAdult:
500 mg once daily for 1 day followed by 250 mg once daily for 4 days.
For the treatment of urethritis and cervicitis: 1 - 2 g as a single dose
Prophylaxis of MAC: 1200 mg once weekly
Chancroid: 1000 mg as a single dose
Children: 10 mg / kg body weight once daily on 1 day followed by 5 mg / kg body weight once daily for 4 days.
Schedule of AzithromycinHStorage Requirements for AzithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of AzithromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of AzithromycinGive supportive measures and symptomatic treatmentAmbroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Azithromycin + Ambroxol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including azithromycin + ambroxol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for azithromycin + ambroxol and other medicines and health products. Home delivery services for azithromycin + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take azithromycin + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for azithromycin + ambroxol before they complete the sale. You can get this information while placing the order for azithromycin + ambroxol with the pharmacy.
Azithromycin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for azithromycin + ambroxol might be better known than azithromycin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have azithromycin + ambroxol in stock, you can ask for one of the branded alternatives for azithromycin + ambroxol.
