Hydroquinone + Tretinoin + Fluocinolone Acetonide Pharmacology
Hydroquinone + Tretinoin + Fluocinolone Acetonide
2.Desquamation
3.Burning
4.Dryness
5.Pruritus
6.Acne
7.Paresthesia
8.Telangiectasia
9.Hyperesthesia
10.Pigmentary changes
11.Irritation
12.Papules
2.Hydroquinone and tretinoin may cause mild to moderate irritation
3.Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing?s syndrome, hyperglycemia, and glucosuria can also be produced by systemic absorption of topical corticosteroid while on treatment. If HPA axis suppression is noted, the use should be discontinued. Recovery of HPA axis function generally occurs upon discontinuation of topical corticosteroids.
4.Exposure to sunlight, sunlamp, or ultraviolet light should be avoided
5.Weather extremes, such as heat or cold, may be irritating to patients treated with Cream. Because of the drying effect of this medication, a moisturizer may be applied to the face in the morning after washing.
2.Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply a thin film of the cream to the hyperpigmented areas of melasma including about 1/2 inch of normal appearing skin surrounding each lesion. Rub lightly and uniformly into the skin. Do not use occlusive dressing.
3.During the day, use a sunscreen of SPF 30, and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day.
4.Therapeutic effects may be observed as early as 4 weeks. Use Cream daily for as long as the melasma lesions persist. Treatment should be discontinued when melasma is resolved. When melasma recurs, retreat with Cream until the condition clears.
Hydroquinone
2. Allergic reactions
3. Rashes
4. Burning
5. Stinging
6. Itching
7. Redness
8. Irritation
2. Care should be taken to avoid it`s entry to eyes, nose, lips or mouth
3. Avoid exposure to sunlight
4. Use a sunscreen and wear protective clothing when exposure to the sun
5. Do not use hydroquinone topical on burned, dry, chapped, or irritated skin, or on an open wound. It could make these conditions worse
6. Hepatic impairment
7. Renal impairment
8. Along with other topical medication on the same area
2. Freckles
3. Hyperpigmention
4. Lentigo
Tretinoin
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
2. Abraded skin
3. Sunburn
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
NEONATES : Use with caution
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Fluocinolone acetonide
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
NEONATES: contraindicated
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)
Home Delivery for Hydroquinone + Tretinoin + Fluocinolone Acetonide in Your City
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Hydroquinone + Tretinoin + Fluocinolone Acetonide is a generic medicine name and there are several brands available for it. Some of the brands for hydroquinone + tretinoin + fluocinolone acetonide might be better known than hydroquinone + tretinoin + fluocinolone acetonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroquinone + tretinoin + fluocinolone acetonide in stock, you can ask for one of the branded alternatives for hydroquinone + tretinoin + fluocinolone acetonide.
