Cefuroxime + Sulbactam Pharmacology

Cefuroxime + Sulbactam

About Cefuroxime + Sulbactam
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Mechanism of Action of Cefuroxime + Sulbactam
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Pharmacokinets of Cefuroxime + Sulbactam
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Onset of Action for Cefuroxime + Sulbactam
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Duration of Action for Cefuroxime + Sulbactam
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Half Life of Cefuroxime + Sulbactam
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Side Effects of Cefuroxime + Sulbactam
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Contra-indications of Cefuroxime + Sulbactam
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Special Precautions while taking Cefuroxime + Sulbactam
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Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Cefuroxime + Sulbactam
1.Sepsis
2.Meningitis
3.Abdominal infections (peritonitis, infections of the biliary and gastrointestinal tracts)
4.Infections of the bones, joints, soft tissue, skin and of wounds
5.Infections in patients with impaired defence mechanisms
6.Renal and urinary tract infections;
7.Respiratory tract infections, particularly pneumonia, and ear, nose and throat infections
8.Genital infections, including gonorrhoea
9.Perioperative prophylaxis of infections
Interactions for Cefuroxime + Sulbactam
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Typical Dosage for Cefuroxime + Sulbactam
Adults:The recommended adult dosage is 1.5 g (1 g Ceftriaxone as the sodium salt plus 0.5 g sulbactam as the sodium salt) to 3 g (2 g Ceftriaxone as the sodium salt plus 1 g sulbactam as the sodium salt) every six hours. The total dose of sulbactam should not exceed 4 grams per day.

Neonates, infants and children up to 12 years:The following dosage schedules are recommended for once daily administration. Neonates (up to 14 days): 20 to 50 mg/kg bodyweight once daily. The daily dose should not exceed 50 mg/kg. It is not necessary to differentiate between premature and term infants.

Infants and children (15 days to 12 years): 20 to 80 mg/kg once daily. For children with bodyweights of 50 kg or more, the usual adult dosage should be used. Intravenous doses is 50 mg/kg bodyweight should be given by infusion over at least 30 minutes.
Schedule of Cefuroxime + Sulbactam
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Storage Requirements for Cefuroxime + Sulbactam
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Effects of Missed Dosage of Cefuroxime + Sulbactam
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Effects of Overdose of Cefuroxime + Sulbactam
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Cefuroxime

About Cefuroxime
Second Generation Cephalosporin antibiotic.
Mechanism of Action of Cefuroxime
Cefuroxime is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefuroxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefuroxime

Pharmacokinets of Cefuroxime
Cefuroxime sodium is orally not well absorbed & should be given parenterally but Cefuroxime axetil is absorbed orally & food increases absorption rate. Distribution: widely distributed, & greater CSF penetration. Metabolism: Not metabolized, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Onset of Action for Cefuroxime
Within 1 hour
Duration of Action for Cefuroxime
12 hours
Half Life of Cefuroxime
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Side Effects of Cefuroxime
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestations
3.Vaginitis
4.Nephrotoxicity
5.Pseudo membranous colitis
6.Pruritus
7.Candidiasis
8.Glossitis
9.Nausea
10.Vomiting
11.Elevated liver enzymes
12.Neutropenia
13.Thrombocytopenia
14.Hemolytic anemia
Contra-indications of Cefuroxime
1.Hypersensitivity to Cefuroxime or other cephalosporins
2.Along with other nephrotoxic drugs
3.Along with oral anticoagulants
4.Pseudo membranous colitis
Special Precautions while taking Cefuroxime
1.Pseudomembranous colitis
2.Patients sensitive to Penicillin
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Cefuroxime
1.Meningitis caused by H.influenzae, meningococci, pneumococci etc.
2.Gonorrhea
3.Pneumonia & Pulmonary infections
4.Infections caused by ampicillin resistant H. influenzae
5.Septicemia
6.Tonsillitis
7.Pharyngitis
8.Urinary tract infections
9.Otitis media
Interactions for Cefuroxime
Synergy with aminoglycosides.
Typical Dosage for Cefuroxime
Adults:
Oral dose: 0.25 to 0.5gm two times daily
Parenteral dose: 0.75 to 1.5gm I.M or I.V. thrice daily for 5 to 10 days.
Severe infections: 1.5gm I.M. or I.V. four times daily
Meningitis: 3gm I.M.or I.V. thrice daily
Tonsillitis, Pharyngitis, Urinary tract infections etc.: 125 to 500mg orally twice daily up to 10 days

Children:30 to 100mg/kg/day I.M or I.V. three times daily or four times daily
Meningitis: Initially 200 to 240mg/kg/day I.V. three times daily or four times daily & continue the therapy with 100mg/kg/day.
Tonsillitis, Pharyngitis, Urinary tract infections etc.:
Above 1`2 years:same as adult dose
Below 12 years: 0.125gm to 0.25gm orally twice daily for 10 days or :20mg/kg/day oral suspension twice daily for 10 days
Otitismedia: 30mg/kg/day orally twice daily
Schedule of Cefuroxime
H
Storage Requirements for Cefuroxime
Store in a cool place.
Effects of Missed Dosage of Cefuroxime
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cefuroxime
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures.

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Special Precautions while taking
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Typical Dosage for
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Home Delivery for Cefuroxime + Sulbactam in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefuroxime + sulbactam and other medicines and health products. Home delivery services for cefuroxime + sulbactam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefuroxime + sulbactam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefuroxime + sulbactam before they complete the sale. You can get this information while placing the order for cefuroxime + sulbactam with the pharmacy.

Cefuroxime + Sulbactam is a generic medicine name and there are several brands available for it. Some of the brands for cefuroxime + sulbactam might be better known than cefuroxime + sulbactam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefuroxime + sulbactam in stock, you can ask for one of the branded alternatives for cefuroxime + sulbactam.