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- Pharmacology For Fenofibrate + Atorvastatin + Ezetimibe
Fenofibrate + Atorvastatin + Ezetimibe Pharmacology
Fenofibrate + Atorvastatin + Ezetimibe
About Fenofibrate + Atorvastatin + EzetimibeN/AMechanism of Action of Fenofibrate + Atorvastatin + EzetimibeN/APharmacokinets of Fenofibrate + Atorvastatin + EzetimibeN/AOnset of Action for Fenofibrate + Atorvastatin + EzetimibeN/ADuration of Action for Fenofibrate + Atorvastatin + EzetimibeN/AHalf Life of Fenofibrate + Atorvastatin + EzetimibeN/ASide Effects of Fenofibrate + Atorvastatin + EzetimibeN/AContra-indications of Fenofibrate + Atorvastatin + EzetimibeN/ASpecial Precautions while taking Fenofibrate + Atorvastatin + EzetimibeN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNot recommended
NEONATES:ContraindicatedIndications for Fenofibrate + Atorvastatin + EzetimibeMixed dyslipidaemiaInteractions for Fenofibrate + Atorvastatin + EzetimibeN/ATypical Dosage for Fenofibrate + Atorvastatin + EzetimibeN/ASchedule of Fenofibrate + Atorvastatin + EzetimibeN/AStorage Requirements for Fenofibrate + Atorvastatin + EzetimibeN/AEffects of Missed Dosage of Fenofibrate + Atorvastatin + EzetimibeN/AEffects of Overdose of Fenofibrate + Atorvastatin + EzetimibeN/AFenofibrate
About FenofibrateFibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.Mechanism of Action of FenofibrateIt is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.Pharmacokinets of FenofibrateAbsorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for FenofibrateN/ADuration of Action for FenofibrateN/AHalf Life of Fenofibrate20 hoursSide Effects of Fenofibrate1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia
Contra-indications of Fenofibrate1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
Special Precautions while taking Fenofibrate1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Fenofibrate1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.Interactions for FenofibrateN/ATypical Dosage for FenofibrateOral: 200mg once daily with food. Adjust the dosage based on patient`s response.Schedule of FenofibrateHStorage Requirements for FenofibrateStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.Effects of Missed Dosage of FenofibrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FenofibrateDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.Atorvastatin
About AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.Ezetimibe
About EzetimibeCholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.Mechanism of Action of EzetimibeIt reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.Pharmacokinets of EzetimibeAbsorption- Poorly absorbed after oral administration
Distribution- Widely distributed in the body as plasma protein binding form (>90%)
Metabolism- Metabolized in the liver and intestinal wall
Excretion- Excreted through urine and feces
Onset of Action for EzetimibeN/ADuration of Action for EzetimibeN/AHalf Life of Ezetimibe19-30 hoursSide Effects of Ezetimibe1. Difficulty breathing
2. Closing of the throat
3. Swelling of the lips, tongue, or face
4. Abdominal pain
5. Diarrhea
6. Tiredness
7. Headache
8. Dizziness
9. Sore throat
10. Runny nose
11. Sneezing
12. Joint pain
13. Rash
14. Itching.
15. Hoarseness
16. Upset stomach
17. Unusual bleeding or bruising
18. Loss of appetite
19. Pain in the upper right part of the stomach
20. Yellowing of the skin or eyes
21. flu-like symptoms
22. Muscle pain or weakness
23. Fever
24. Chills
25. Pale or fatty stools
26. Chest pain
Contra-indications of EzetimibeContraindicated in patients with hypersensitivity to the drug or any components of it
Special Precautions while taking Ezetimibe1. Liver disease
2. Liver enzymes, persistently high levels
3. Major surgery or serious illness
4. Diabetes mellitus
5. Kidney disease
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ezetimibe1. Adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia
2. Adjunct to dietary measures in homozygous familial sitosterolaemia
Interactions for EzetimibeCyclosporin: Plasma concentraction of ezetimibe increased. Lipid-regulating drugs: Avoid concomitant use with fibrates.Typical Dosage for EzetimibeOral-
Adult -10 mg/day
Schedule of EzetimibeN/AStorage Requirements for EzetimibeStored at room temperature (15-30 degree C).Effects of Missed Dosage of EzetimibeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EzetimibeGive symptomatic and supportive treatmentHome Delivery for Fenofibrate + Atorvastatin + Ezetimibe in Your City
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Fenofibrate + Atorvastatin + Ezetimibe is a generic medicine name and there are several brands available for it. Some of the brands for fenofibrate + atorvastatin + ezetimibe might be better known than fenofibrate + atorvastatin + ezetimibe itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fenofibrate + atorvastatin + ezetimibe in stock, you can ask for one of the branded alternatives for fenofibrate + atorvastatin + ezetimibe.
