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- Pharmacology For Hydroquinone + Tretinoin + Mometasone
Hydroquinone + Tretinoin + Mometasone Pharmacology
Hydroquinone + Tretinoin + Mometasone
About Hydroquinone + Tretinoin + MometasoneN/AMechanism of Action of Hydroquinone + Tretinoin + MometasoneN/APharmacokinets of Hydroquinone + Tretinoin + MometasoneN/AOnset of Action for Hydroquinone + Tretinoin + MometasoneN/ADuration of Action for Hydroquinone + Tretinoin + MometasoneN/AHalf Life of Hydroquinone + Tretinoin + MometasoneN/ASide Effects of Hydroquinone + Tretinoin + Mometasone1.Aching
2.Blisters in hair follicles
3.Thinning of the skin
4.Burning or itching of the skin
5.Increased redness of the skin
6.Irritation of the skin
Contra-indications of Hydroquinone + Tretinoin + MometasoneN/ASpecial Precautions while taking Hydroquinone + Tretinoin + MometasoneN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationNot recommendedIndications for Hydroquinone + Tretinoin + MometasoneFor treatment of hyperpigmentation,melasma,chloasma,acne vulgaris,contact dermatitis and psoriasis.Interactions for Hydroquinone + Tretinoin + MometasoneN/ATypical Dosage for Hydroquinone + Tretinoin + MometasoneN/ASchedule of Hydroquinone + Tretinoin + MometasoneN/AStorage Requirements for Hydroquinone + Tretinoin + MometasoneN/AEffects of Missed Dosage of Hydroquinone + Tretinoin + MometasoneN/AEffects of Overdose of Hydroquinone + Tretinoin + MometasoneN/AHydroquinone
About HydroquinoneBenzenediol derivative, Depigmenting Agent.Mechanism of Action of HydroquinoneHydroquinone decreases the formation of melanin in the skin. It inhibits tyrosinase and other melanin forming enzymes and thus decreases the formation and increases the degradation of melanosomes.Pharmacokinets of HydroquinoneAbsorption: Administered topically.Onset of Action for HydroquinoneN/ADuration of Action for HydroquinoneN/AHalf Life of HydroquinoneN/ASide Effects of Hydroquinone1. Skin irritation
2. Allergic reactions
3. Rashes
4. Burning
5. Stinging
6. Itching
7. Redness
8. Irritation
Contra-indications of Hydroquinone1. Hypersensitivity to the drugSpecial Precautions while taking Hydroquinone1. Discontinue the drug if skin irritation occurs
2. Care should be taken to avoid it`s entry to eyes, nose, lips or mouth
3. Avoid exposure to sunlight
4. Use a sunscreen and wear protective clothing when exposure to the sun
5. Do not use hydroquinone topical on burned, dry, chapped, or irritated skin, or on an open wound. It could make these conditions worse
6. Hepatic impairment
7. Renal impairment
8. Along with other topical medication on the same area
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Hydroquinone1. Melasma
2. Freckles
3. Hyperpigmention
4. Lentigo
Interactions for HydroquinoneN/ATypical Dosage for Hydroquinone2 to 6% cream or lotion for months as required. Apply evenly on the affected areas two times daily; in the morning and evening. Massage the cream on the skin. Schedule of HydroquinoneN/AStorage Requirements for HydroquinoneStore at room temperature at a range of 15 to 30 degree C. Protect from moisture and heat. Do not freeze and keep out of reach of children.Effects of Missed Dosage of HydroquinoneUse the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of HydroquinoneRinse with water and Provide symptomatic treatment and supportive measures. Tretinoin
About TretinoinRetinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.Mechanism of Action of TretinoinTretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reducedPharmacokinets of TretinoinAbsorption: Absorption after topical application is minimal.Onset of Action for TretinoinN/ADuration of Action for TretinoinN/AHalf Life of TretinoinN/ASide Effects of Tretinoin1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
Contra-indications of Tretinoin1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn
Special Precautions while taking Tretinoin1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Tretinoin1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Interactions for TretinoinSulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.Typical Dosage for TretinoinTopical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Schedule of TretinoinHStorage Requirements for TretinoinStore at 15 - 25 degree C in a tightly closed container.Effects of Missed Dosage of TretinoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TretinoinGive supportive measures and symptomatic treatment.Mometasone
About MometasoneA glucocorticoid steroid, Anti psoriatic,anti asthma ,anti inflammatory.Mechanism of Action of MometasoneMometasone is a topical medium potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of MometasoneAbsorption: Mometasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier. Absorption is increased in inflammation, occlusion and skin damage.Onset of Action for MometasoneN/ADuration of Action for MometasoneN/AHalf Life of MometasoneN/ASide Effects of Mometasone1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
12.Dry skin
13.Stinging
14.TinglingContra-indications of Mometasone1.Hypersensitivity to Mometasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Mometasone1.Avoid the use of medicament if irritation or hypersensitivity occurs
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7.Withdraw gradually after prolonged use
8.Use caution on areas where the skin creases, such as armpits, knees, and elbows
9.Avoid application on large surface areaPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Mometasone1.Otitis externa
2 Eczema
3.Dermatoses (secondary infected)
4.Psoriasis
5.Neuro dermatitis
6.Intertrigo
7.Lichen planus
8.Anal and vulval pruritisInteractions for MometasoneN/ATypical Dosage for MometasoneTopical: Mometasone Furoate 0.1 % cream, ointment or lotion is used.
Clean the affected area and wash with warm water and then dry. Apply 2 - 3 times daily for 2 weeks with gentle massage.
Schedule of MometasoneHStorage Requirements for MometasoneStore at room temperature. Protect from heat and light. Keep the container tightly closed. Keep out of the reach of childrenEffects of Missed Dosage of MometasoneApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MometasoneGive supportive measures and symptomatic treatment.
Home Delivery for Hydroquinone + Tretinoin + Mometasone in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroquinone + tretinoin + mometasone and other medicines and health products. Home delivery services for hydroquinone + tretinoin + mometasone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take hydroquinone + tretinoin + mometasone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroquinone + tretinoin + mometasone before they complete the sale. You can get this information while placing the order for hydroquinone + tretinoin + mometasone with the pharmacy.
Hydroquinone + Tretinoin + Mometasone is a generic medicine name and there are several brands available for it. Some of the brands for hydroquinone + tretinoin + mometasone might be better known than hydroquinone + tretinoin + mometasone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroquinone + tretinoin + mometasone in stock, you can ask for one of the branded alternatives for hydroquinone + tretinoin + mometasone.
