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- Pharmacology For Ceftriaxone + Vancomycin
Ceftriaxone + Vancomycin Pharmacology
Ceftriaxone + Vancomycin
About Ceftriaxone + VancomycinN/AMechanism of Action of Ceftriaxone + VancomycinN/APharmacokinets of Ceftriaxone + VancomycinN/AOnset of Action for Ceftriaxone + VancomycinN/ADuration of Action for Ceftriaxone + VancomycinN/AHalf Life of Ceftriaxone + VancomycinN/ASide Effects of Ceftriaxone + VancomycinN/AContra-indications of Ceftriaxone + VancomycinN/ASpecial Precautions while taking Ceftriaxone + VancomycinN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Ceftriaxone + Vancomycin1.Bacterial meningitis
2.Prophylaxis of shunt infections
3.Brain abscess
4.Suppurative intracranial infections
5.Abdominal infections
6.Pneumonia
7.Acute bacterial endocarditis.
8.Bone and joint infections
9.Over whelming post-splenectomy sepsis
10.Purpura fulminans
Interactions for Ceftriaxone + VancomycinN/ATypical Dosage for Ceftriaxone + Vancomycin(Ceftriaxone-Vancomycin) can be administrated through slow intravenous injection over atleast 60 minutes. Do not dilute with calcium containing solutions .
Doses: Adults: (Ceftraixone 2 g + Vancomycin 1 g ) 3g b.i.d
Paediatric Doses : 60mg / kg body weight
Doses should be adjusted in patients with marked decrease in the renal function
Schedule of Ceftriaxone + VancomycinN/AStorage Requirements for Ceftriaxone + VancomycinN/AEffects of Missed Dosage of Ceftriaxone + VancomycinN/AEffects of Overdose of Ceftriaxone + VancomycinN/ACeftriaxone
About CeftriaxoneThird Generation Cephalosporin antibiotic(Parenteral).Mechanism of Action of CeftriaxoneCeftriaxone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftriaxone.
Pharmacokinets of CeftriaxoneAbsorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: A portion of the drug is metabolized in the body. Excretion:
Excreted through urine & bile. A small portion of drug appears in breast milk.Onset of Action for CeftriaxoneSuddenDuration of Action for Ceftriaxone8 hoursHalf Life of CeftriaxoneN/ASide Effects of Ceftriaxone1.Nausea
2.Vomiting
3.Diarrhoea
4.Superinfection
5.Skin rash
6.Urticaria
7.Pseudomembranous colitis
8.Pain at site of injectionContra-indications of CeftriaxoneHypersensitivity to CeftriaxoneSpecial Precautions while taking Ceftriaxone1.Hepatic impairment
2.Renal impairmentPregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be used
Neonates: Use with caution
Indications for Ceftriaxone1.Meningitis
2.Septicaemia
3.Typhoid
4.UTI
5.Prophylaxis in surgical infections
6.Lower respiratory tract infections
7.Pneumonia
8.Pelvic inflammatory disease
9.STD
10.BacteraemiaInteractions for CeftriaxoneAlcohol: Disulfiram like reaction.
Aminoglycosides & fruesmide: Nephrotoxicity potentiated.
Chloramphenicol: Decreased efficacy of ceftriaxone.Typical Dosage for CeftriaxoneAdults: 1g to 2gm I.M. or I.V. Once daily or two times daily
Maximum adult dose: Up to 4gm/day
Meningitis & Endocarditis: 1 to 2gm I.M. or I.V twice daily; two weeks for meningitis & four weeks for endocarditis
Gonorrhea: 250mg once daily
Children: 50 to 100 mg/kg/day I.M or I.V. two times daily
Maximum child dose: 2g/day
Meningitis & Endocarditis: 50 to 100 mg/kg/day twice daily; two weeks for meningitis & four weeks for endocarditis
Schedule of CeftriaxoneHStorage Requirements for CeftriaxoneN/AEffects of Missed Dosage of CeftriaxoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CeftriaxoneSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment is supportive.Vancomycin
About VancomycinA tricyclic glycopeptide antibiotic.Mechanism of Action of VancomycinVancomycin binds to the terminal dipeptide sequence of peptidoglycan and inhibits the association and cross linking of peptidoglycan and as the result inhibit cell wall synthesis.Pharmacokinets of VancomycinAbsorption: It is well absorbed after parenteral administration.
Distribution: It is very widely distributed in the body.
Excretion: It is excreted through urine.
Onset of Action for VancomycinWithin minuteDuration of Action for Vancomycin6 - 8 hoursHalf Life of Vancomycin4 - 6 hoursSide Effects of Vancomycin1. Thrombophlebitis
2. Pain at the site of injection
3. Fever
4. Necrosis
5. Chills
6. Urticaria
7. Rashes
8. Flushing
9. Neutropenia
10. Oototoxicity
Contra-indications of Vancomycin1.Hypersensitive to VancomycinSpecial Precautions while taking Vancomycin1. Renal impairment
2. Hepatic dysfunction
3. Hearing problems
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Vancomycin1. Endocarditis
2. Pseudomembranous enterocolitis
3. Methicillin resistant Staphylococcus aureus infection
4. Staphylococcal enterocolitis
Interactions for VancomycinAnion-exchange resins: Antagonism of oral vancomycin by cholestyramine.
Aminoglycosides: Risk of nephrotoxicity may be increased.
Anaesthetics: Erythema and histamine like flushing in children.
Nondepolorizing Muscle Relaxants: The neuromuscular blockade may be enhanced.
Typical Dosage for VancomycinAdult (IV dose):500 mg every four times a day
Enterocolitis (oral) 0.5 - 2 g / day in four divided dose for 10 days
Children :( IV dose) 40 mg /kg body weight / day in four divided dose
Neonates: Initial dose: 15mg / kg followed by 20 mg / kg body weight /day in two divided dose for 1 week and then in three divided dose up to 1 month.
Schedule of VancomycinHStorage Requirements for VancomycinStore in room temperature. Keep away from moisture and light.Effects of Missed Dosage of VancomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of VancomycinGive supportive treatment and measures. Maintain glomerular filtration rate. Then if needed haemodialysis or haemoperfusion can be done.Home Delivery for Ceftriaxone + Vancomycin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ceftriaxone + vancomycin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ceftriaxone + vancomycin and other medicines and health products. Home delivery services for ceftriaxone + vancomycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ceftriaxone + vancomycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ceftriaxone + vancomycin before they complete the sale. You can get this information while placing the order for ceftriaxone + vancomycin with the pharmacy.
Ceftriaxone + Vancomycin is a generic medicine name and there are several brands available for it. Some of the brands for ceftriaxone + vancomycin might be better known than ceftriaxone + vancomycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ceftriaxone + vancomycin in stock, you can ask for one of the branded alternatives for ceftriaxone + vancomycin.
