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- Pharmacology For Flavoxate + Ofloxacin
Flavoxate + Ofloxacin Pharmacology
Flavoxate + Ofloxacin
About Flavoxate + OfloxacinN/AMechanism of Action of Flavoxate + OfloxacinN/APharmacokinets of Flavoxate + OfloxacinN/AOnset of Action for Flavoxate + OfloxacinN/ADuration of Action for Flavoxate + OfloxacinN/AHalf Life of Flavoxate + OfloxacinN/ASide Effects of Flavoxate + OfloxacinN/AContra-indications of Flavoxate + OfloxacinN/ASpecial Precautions while taking Flavoxate + OfloxacinN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Flavoxate + OfloxacinUrinary tract infectionsInteractions for Flavoxate + OfloxacinN/ATypical Dosage for Flavoxate + OfloxacinN/ASchedule of Flavoxate + OfloxacinN/AStorage Requirements for Flavoxate + OfloxacinN/AEffects of Missed Dosage of Flavoxate + OfloxacinN/AEffects of Overdose of Flavoxate + OfloxacinN/AFlavoxate
About FlavoxateMuscarinic antagonist(anticholinergic ) Flavones and their glycosides, Muscle relaxant, systemic urinary tract antispasmodic.Mechanism of Action of FlavoxateThis is a direct antagonist drug which act on muscarinic acetylcholine receptors in innervated organs especially in bladder. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder and relaxing the involuntary muscle that is found in the wall of the bladder. This effectively reduce the number of required voids, urge incontinence episodes, urge severity and improving retention, facilitating increased volume per void.Pharmacokinets of FlavoxateAbsorption- Well absorbed after oral administration
Excretion- Excreted through urine
Onset of Action for FlavoxateBelow 2 hoursDuration of Action for Flavoxate6-8 hoursHalf Life of FlavoxateN/ASide Effects of Flavoxate1. Dizziness
2. Drowsiness
3. Blurred vision
4. Nausea
5. Vomiting
6. Dry mouth
7. Nervousness
8. Headache
9. Confusion
10. Dryness of the eyes
11. Large pupil
12. Difficulty urinating
Contra-indications of Flavoxate1. Hypersensitivity to the drug
2. Blockage of the urinary tract (difficulty urinating).
3. Bleeding in the stomach
4. Blockage in the intestines
5. Pyloric or duodenal obstruction
6. Obstructive intestinal lesions or ileus
7. Achalasia
8. Gastrointestinal hemorrhage
9. Obstructive uropathies of the lower urinary tract
Special Precautions while taking Flavoxate1. Glaucoma
2. Require mental alertness such as driving, operating machinery, or performing other hazardous activities
3. Alcohol dependent
4. Prostrate hypertrophy
5. Hiatus hernia with reflex
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Flavoxate1. Spasms of the bladder and urinary tract.
2. Urinary frequency
3. Urinary urgency
4. Urinary leakage
5. Painful or difficult urination
6. Urinary incontinence.
7. Interstitial cystitis
8. Nocturia
9. Suprapubic pain
10. Prostatitis
11. Urethrocystitis/urethrotrigonitis
12. Urethritis
Interactions for FlavoxateN/ATypical Dosage for FlavoxateOral-
Adults and children over 12 years of age -
100-200 mg tablets 3 or 4 times a day
Schedule of FlavoxateHStorage Requirements for FlavoxateStore between 15? and 30? C (59? and 86? F)Effects of Missed Dosage of FlavoxateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of FlavoxateGive symptomatic and supportive treatment. Ofloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Home Delivery for Flavoxate + Ofloxacin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flavoxate + ofloxacin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flavoxate + ofloxacin and other medicines and health products. Home delivery services for flavoxate + ofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take flavoxate + ofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flavoxate + ofloxacin before they complete the sale. You can get this information while placing the order for flavoxate + ofloxacin with the pharmacy.
Flavoxate + Ofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for flavoxate + ofloxacin might be better known than flavoxate + ofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flavoxate + ofloxacin in stock, you can ask for one of the branded alternatives for flavoxate + ofloxacin.
