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- Pharmacology For Lornoxicam + Thiocolchicoside
Lornoxicam + Thiocolchicoside Pharmacology
Lornoxicam + ThiocolchicosideAbout Lornoxicam + ThiocolchicosideN/AMechanism of Action of Lornoxicam + ThiocolchicosideN/APharmacokinets of Lornoxicam + ThiocolchicosideN/AOnset of Action for Lornoxicam + ThiocolchicosideN/ADuration of Action for Lornoxicam + ThiocolchicosideN/AHalf Life of Lornoxicam + ThiocolchicosideN/ASide Effects of Lornoxicam + ThiocolchicosideN/AContra-indications of Lornoxicam + ThiocolchicosideN/ASpecial Precautions while taking Lornoxicam + ThiocolchicosideN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNot recommendedIndications for Lornoxicam + ThiocolchicosideFor the treatment of acute Painful muscoloskeletal conditionInteractions for Lornoxicam + ThiocolchicosideN/ATypical Dosage for Lornoxicam + ThiocolchicosideN/ASchedule of Lornoxicam + ThiocolchicosideN/AStorage Requirements for Lornoxicam + ThiocolchicosideN/AEffects of Missed Dosage of Lornoxicam + ThiocolchicosideN/AEffects of Overdose of Lornoxicam + ThiocolchicosideN/A
LornoxicamAbout LornoxicamNon-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. It is available in oral and parenteral formulations.Mechanism of Action of LornoxicamLike other NSAIDs, lornoxicam inhibits prostaglandin biosynthesis by blocking the enzyme cyclooxygenase. Lornoxicam inhibits both isoforms in the same concentration range, that is, the ratio of COX-1 inhibition to COX-2 inhibition is 1:1. It readily penetrates into the synovial fluid.Pharmacokinets of LornoxicamAbsorption:well absorbed oraly,food delays absorption
Distribution: 99% bound to plasma proteins.
Metabolism: Metabolised to its inactive metabolite
Elimination:Approximately 1/2 to 2/3 is eliminated via the liver and 1/3 to 42% via the
kidneys as 5?-hydroxylornoxicam.
Onset of Action for LornoxicamN/ADuration of Action for LornoxicamN/AHalf Life of Lornoxicam3-4 hr.Side Effects of Lornoxicam1.Gastrointestinal disorders (nausea and diarrhea)
3.Severe but seldom side effects include bleeding, bronchospasms and the extremely rare stevens?johnson syndrome
Contra-indications of Lornoxicam1.Salicylate sensitivity
2.Gastrointestinal bleeding and bleeding disorders
3.Severe impairment of heart, liver or kidney function
Special Precautions while taking Lornoxicam1.Active infections
6.Impaired renal, hepatic, cardiac function.
7.Lornoxicam should be taken with a meal to minimise gastrointestinal irritation.
Pregnancy Related InformationCotra indicatedOld Age Related InformationReduce the doseBreast Feeding Related InformationCotra indicatedChildren Related InformationDo not use lornoxicam in children under the age of 18Indications for LornoxicamTreatment of various types of pain, especially resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica, and other inflammations.Interactions for Lornoxicam1.Vitamin K antagonists like warfarin increases the risk of bleeding.
2.Ciclosporin can lead to reduced kidney function, and to acute renal failure in rare cases.
3.Lornoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives.
4.The effect of diuretics, ACE inhibitors and angiotensin II receptor antagonists can be reduced, but this is only relevant in patients with special risks like heart failure.
5.Piroxicam, cimetidine can increase plasma levels
Typical Dosage for Lornoxicam1.Pain relief:Adult: 8-16 mg daily. Max: 24 mg daily. (Oral)
2.Osteoarthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.(Oral)
3.Rheumatoid arthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.Parenteral
4.Pain relief:Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.
Schedule of LornoxicamSchedule HStorage Requirements for LornoxicamN/AEffects of Missed Dosage of LornoxicamN/AEffects of Overdose of LornoxicamA small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.
ThiocolchicosideAbout ThiocolchicosideA GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.Mechanism of Action of ThiocolchicosideThiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.Pharmacokinets of ThiocolchicosideN/AOnset of Action for ThiocolchicosideN/ADuration of Action for ThiocolchicosideN/AHalf Life of ThiocolchicosideN/ASide Effects of Thiocolchicoside1. Diarrhoea
6. Anaphylactic reaction
Contra-indications of Thiocolchicoside1. Contraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Thiocolchicoside1. Use with caution in patients with diarrheaPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for ThiocolchicosidePainful muscle spasm associated with
1. Degenerative vertebral disorders
3. Dorsal pain
4. Low back pain
5. Traumatological disorders
6. Neurological disorders
Interactions for ThiocolchicosideNo known interactions with other drugs.Typical Dosage for ThiocolchicosideAdult-
Oral- 4mg twice a day for 5 to 7 days.
4mg twice a day for 3 to 5 days.
Schedule of ThiocolchicosideN/AStorage Requirements for ThiocolchicosideN/AEffects of Missed Dosage of ThiocolchicosideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ThiocolchicosideGive symptomatic and supportive treatment.
Home Delivery for Lornoxicam + Thiocolchicoside in Your City
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Lornoxicam + Thiocolchicoside is a generic medicine name and there are several brands available for it. Some of the brands for lornoxicam + thiocolchicoside might be better known than lornoxicam + thiocolchicoside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lornoxicam + thiocolchicoside in stock, you can ask for one of the branded alternatives for lornoxicam + thiocolchicoside.