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- Pharmacology For Mebendazole + Levamisole
Mebendazole + Levamisole Pharmacology
Mebendazole + LevamisoleAbout Mebendazole + LevamisoleN/AMechanism of Action of Mebendazole + LevamisoleN/APharmacokinets of Mebendazole + LevamisoleN/AOnset of Action for Mebendazole + LevamisoleN/ADuration of Action for Mebendazole + LevamisoleN/AHalf Life of Mebendazole + LevamisoleN/ASide Effects of Mebendazole + LevamisoleN/AContra-indications of Mebendazole + LevamisoleN/ASpecial Precautions while taking Mebendazole + LevamisoleN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Mebendazole + Levamisole1.Round worms infestations.
3.Mixed worm infestations.
Interactions for Mebendazole + LevamisoleN/ATypical Dosage for Mebendazole + LevamisoleSingle dose, in case of severe hookworm infestation, repeat dose after 1 to 7 days.
Schedule of Mebendazole + LevamisoleN/AStorage Requirements for Mebendazole + LevamisoleN/AEffects of Missed Dosage of Mebendazole + LevamisoleN/AEffects of Overdose of Mebendazole + LevamisoleN/A
MebendazoleAbout MebendazoleA benzimidazole derivative, Anthelmintic.Mechanism of Action of MebendazoleMebendazole is a benzimidazole used as a broad spectrum anthelminthic which acts by blocking glucose uptake in the parasite and depletion of its glycogen stores. Intracellular microtubules in the cells of the worm are gradually lost. The drug binds to beta tubulin of susceptible worms with high affinity and inhibits its polymerization. Ascaris ova are killed. It also inhibits hatching of nematode eggs and larvae.Pharmacokinets of MebendazoleAbsorption: Poorly absorbed orally (5 to 10%)
Distribution: Shows protein binding & crosses placenta
Metabolism: Metabolized in to inactive metabolites
Excretion: Excreted mainly in faeces and also in urine
Onset of Action for Mebendazole2 to 3 daysDuration of Action for MebendazoleN/AHalf Life of Mebendazole3 to 9 hoursSide Effects of Mebendazole1. Headache
2. Transient abdominal pain
5. Expulsion of worms
8. Hair loss
Contra-indications of Mebendazole1. Hyper sensitivity to the drugSpecial Precautions while taking Mebendazole1. Monitor blood count during the treatment of Echinococcus granulosus infectionPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationAbove 2 years : May be used
Below 2 years : Contraindicated
Indications for Mebendazole1. Ascariasis
2. Pinworm infection
3. Hook worm infection
4. Tape worm infection
5. Whip worm infections
6. Threadworm infections
7. Hydatid disease
9. Mixed infestation
Interactions for MebendazoleCarbamazepine and Hydantoin: Reduce plasma levels of mebendazole thus decreasing its efficacy.
Food: Fatty food enhance absorption of mebendazole.
Typical Dosage for MebendazoleAdults & Children over 2 years:
Enterobius:100mg single dose, Repeats after 2 to 3 weeks
Round worm, Hook worm and Trichuris:100mg 12hourly for 3days; second course after 14 days if necessary
Tape worm: 0.2gm 12 hourly for 3 days
Trichinella spiralis: 200 to 400mg 12hourly or 8hourly for 3days
Hydatid disease: 200 to 400mg 12hourly or 8hourly for 3 to 4 weeks
Schedule of MebendazoleHStorage Requirements for MebendazoleStore in a well closed container at a temperature range of 15 to 25 degree Centigrade.Effects of Missed Dosage of MebendazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MebendazoleTreatment is supportive & symptomatic. Empty stomach by induced emesis & gastric lavage; within 4 hours after ingestion. Give activated charcoal to reduce absorption.
LevamisoleAbout LevamisoleSynthetic imidazothiazole derivative, Biological response modifier, Anthelmintic, Antineoplastic adjunct.Mechanism of Action of LevamisoleLevamisole is the levo isomer of Tetramisole which is used as an anthelminthic agent. It exerts its action by producing paralysis of worm by causing sustained contraction of somatic muscles of worm by an irreversible, noncompetitive depolarization type of Neuro muscular block. It also non competitively inhibits the production of succinate.Its immunostimalant action is by modulating cell mediated immunity by increasing phagocytosis by macrophages. It restores cutaneous delayed hyper sensitivity reactions.Pharmacokinets of LevamisoleAbsorption: Well absorbed orally.
Metabolism: Metabolized inside the body.
Excretion: Excreted through urine.
Onset of Action for LevamisoleN/ADuration of Action for LevamisoleN/AHalf Life of LevamisoleN/ASide Effects of Levamisole1. Headache
3. Abdominal pain
10 Impaired taste
Contra-indications of Levamisole1. Hypersensitivity to the drug
2. Disorders of blood
Special Precautions while taking Levamisole1. Rheumatoid arthritis
2. Drug causes disulfiram like reaction with alcohol
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Levamisole1. Ascariasis, Mixed Ascaris,
2. Ancylostomiasis (Hookworm infestation)
3. As Immunomodulator in Cancer patients & in Rheumatoid arthritis
Interactions for LevamisoleAlcohol: Levamisole may produce disulfiram like effects with alcohol.
Phenytoin: Co-administration with levamisole and fluorouracil results in increased serum phenytoin levels.
Typical Dosage for LevamisoleAdults:
Ascariasis:2.5 to 5mg/kg or 150mg single oral dose.
Ancylostomiasis & Mixed Ascaris, Hookworm infestation: 0.3gm for 1 to 2 days. Alternatively administer 2.5mg/kg as a single dose. Repeat after 1week if required
Ascariasis:3mg/kg or 50mg single oral dose.
Ancylostomiasis & Mixed Ascaris, Hookworm infestation: 6mg/kg for 1 to 2 days
Schedule of LevamisoleHStorage Requirements for LevamisoleStore at room temperature below 30 degree C. Protect from moisture and light.Effects of Missed Dosage of LevamisoleTake the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.Effects of Overdose of LevamisoleTreatment is supportive & symptomatic. Empty stomach by gastric lavage.
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