Thyroid + Nicotinamide + Pyridoxine Pharmacology

Thyroid + Nicotinamide + Pyridoxine

About Thyroid + Nicotinamide + Pyridoxine
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Mechanism of Action of Thyroid + Nicotinamide + Pyridoxine
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Pharmacokinets of Thyroid + Nicotinamide + Pyridoxine
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Onset of Action for Thyroid + Nicotinamide + Pyridoxine
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Duration of Action for Thyroid + Nicotinamide + Pyridoxine
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Half Life of Thyroid + Nicotinamide + Pyridoxine
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Side Effects of Thyroid + Nicotinamide + Pyridoxine
1.Allergy and gastrointestinal intolerance, especially in higher dosages
2.Fatigue
3.Increased appetite
4.Weight loss
5.Heat intolerance
6.Weight loss
7.Fever
8.Excessive sweating
9.Hair loss
10.Flushing
11.Decreased bone mineral density
12.Central nervous excitability
13.Tremors
14.Weakness
15.Cardiovascular manifestations
16.Dyspnea
17.Menstrual irregularities
18.Infertility.
Contra-indications of Thyroid + Nicotinamide + Pyridoxine
1.Hyper sensitivity
2.Untreated subclinical and overt thyrotoxicosis
3.Untreated adrenal insufficiency
4.For management of male / female infertility unless it is associated with hypothyroidism.
Special Precautions while taking Thyroid + Nicotinamide + Pyridoxine
1.Dose needs to be titrated carefully inorder to avoid consequences of undertreatment and overtreatment with its content of thyroid.
2.Use with caution in osteoporosis and osteopenia, cardiovascular disease and diabetes mellitus.
3.It must be coadministered with sympathomimetics and oral hypoglycemics with due precaution.
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Thyroid + Nicotinamide + Pyridoxine
1.Subclinical hypothyroidism
2.Euthyroid goiters
3.Management of thyroid deficiency as caused by insufficient dietary intake of iodine
4.Congenitally inadequately performing thyroid gland
5.Infections (bacterial and viral) suppressing the thyroid gland
6.Medications known to depress thyroid hormone production such as lithium, nitroprusside and iodides.
Interactions for Thyroid + Nicotinamide + Pyridoxine
1.Concomitant administration of thyroid with sympathomimetics may precipitate coronary insufficiency in coronary artery disease.
2.Diabetics may require upward adjustment of their antidiabetic regimen when thyroid is administered.
3.Other agents that may interfere with action of thyroid include antiepileptics, antacids, amiodarone, contraceptives, anticoagulants, antidepressants, theophylline, thiazides and selective hormones
Typical Dosage for Thyroid + Nicotinamide + Pyridoxine
(Nicotinamide 25 mg Pyridoxine 1 mg Thyroid 15 mg )
Adults:1 Tab daily one-half to one hour before breakfast, or as prescribed.
Children: As prescribed.

Schedule of Thyroid + Nicotinamide + Pyridoxine
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Storage Requirements for Thyroid + Nicotinamide + Pyridoxine
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Effects of Missed Dosage of Thyroid + Nicotinamide + Pyridoxine
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Effects of Overdose of Thyroid + Nicotinamide + Pyridoxine
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About
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Mechanism of Action of
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Side Effects of
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Contra-indications of
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for
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Interactions for
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Typical Dosage for
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Schedule of
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Effects of Missed Dosage of
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Nicotinamide

About Nicotinamide
Water Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid.
Mechanism of Action of Nicotinamide
Nicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Nicotinamide
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Nicotinamide
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Duration of Action for Nicotinamide
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Half Life of Nicotinamide
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Side Effects of Nicotinamide
1.Activation of peptic ulcer
2.Nausea
3.Vomiting
4.Diarrhoea
5.Headache
6.Hypotension
7.Arrhythmias
8.Hepatic impairment
Contra-indications of Nicotinamide
1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage
Special Precautions while taking Nicotinamide
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nicotinamide
1.Pellagra
2.Niacin deficiency
3.Hartnup disease
Interactions for Nicotinamide
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Typical Dosage for Nicotinamide
Pellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Nicotinamide
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Storage Requirements for Nicotinamide
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Nicotinamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nicotinamide
Provide supportive measures and symptomatic treatment.

Pyridoxine

About Pyridoxine
Water soluble vitamin(Vit B6), In Vitamin B6 deficiency ,Neuropathy.
Mechanism of Action of Pyridoxine
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Pharmacokinets of Pyridoxine
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Onset of Action for Pyridoxine
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Duration of Action for Pyridoxine
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Half Life of Pyridoxine
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Side Effects of Pyridoxine
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Contra-indications of Pyridoxine
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Special Precautions while taking Pyridoxine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Pyridoxine
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Interactions for Pyridoxine
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Typical Dosage for Pyridoxine
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Schedule of Pyridoxine
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Storage Requirements for Pyridoxine
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Effects of Missed Dosage of Pyridoxine
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Effects of Overdose of Pyridoxine
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