Metaxalone + Diclofenac Potassium Pharmacology

Metaxalone + Diclofenac Potassium

About Metaxalone + Diclofenac Potassium
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Mechanism of Action of Metaxalone + Diclofenac Potassium
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Pharmacokinets of Metaxalone + Diclofenac Potassium
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Onset of Action for Metaxalone + Diclofenac Potassium
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Duration of Action for Metaxalone + Diclofenac Potassium
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Half Life of Metaxalone + Diclofenac Potassium
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Side Effects of Metaxalone + Diclofenac Potassium
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Contra-indications of Metaxalone + Diclofenac Potassium
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Special Precautions while taking Metaxalone + Diclofenac Potassium
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution;>12yrs:Contraindicated
Indications for Metaxalone + Diclofenac Potassium
For acute painful musculoskeletal condition in adult
Interactions for Metaxalone + Diclofenac Potassium
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Typical Dosage for Metaxalone + Diclofenac Potassium
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Schedule of Metaxalone + Diclofenac Potassium
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Storage Requirements for Metaxalone + Diclofenac Potassium
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Effects of Missed Dosage of Metaxalone + Diclofenac Potassium
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Effects of Overdose of Metaxalone + Diclofenac Potassium
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Metaxalone

About Metaxalone
Centrally acting Skeletal Muscle Relaxant, Muscle Relaxant.
Mechanism of Action of Metaxalone
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Pharmacokinets of Metaxalone
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Onset of Action for Metaxalone
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Duration of Action for Metaxalone
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Half Life of Metaxalone
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Side Effects of Metaxalone
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Contra-indications of Metaxalone
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Special Precautions while taking Metaxalone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Metaxalone
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Interactions for Metaxalone
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Typical Dosage for Metaxalone
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Schedule of Metaxalone
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Storage Requirements for Metaxalone
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Effects of Missed Dosage of Metaxalone
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Effects of Overdose of Metaxalone
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Diclofenac Potassium

About Diclofenac Potassium
NSAID, anti-inflammatory ,antipyretic and analgesic.
Mechanism of Action of Diclofenac Potassium
Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.
Pharmacokinets of Diclofenac Potassium
Absorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
Onset of Action for Diclofenac Potassium
Analgesic action: with in 60 minutes and Antirheumatic action with in 2 weeks
Duration of Action for Diclofenac Potassium
12hours
Half Life of Diclofenac Potassium
1-2 hours
Side Effects of Diclofenac Potassium
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13.Rash
Contra-indications of Diclofenac Potassium
1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Potassium
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 14: contraindicated
Indications for Diclofenac Potassium
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
7.Dysmenorrhoea
8.Migraine
Interactions for Diclofenac Potassium
N/A
Typical Dosage for Diclofenac Potassium
Adult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac Potassium
H
Storage Requirements for Diclofenac Potassium
Store Diclofenac potassium at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Diclofenac Potassium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diclofenac Potassium
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Metaxalone + Diclofenac Potassium in Your City

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