Zinc Pyrithionone + Fluconazole Pharmacology

Zinc Pyrithionone + Fluconazole

About Zinc Pyrithionone + Fluconazole
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Mechanism of Action of Zinc Pyrithionone + Fluconazole
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Pharmacokinets of Zinc Pyrithionone + Fluconazole
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Onset of Action for Zinc Pyrithionone + Fluconazole
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Duration of Action for Zinc Pyrithionone + Fluconazole
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Half Life of Zinc Pyrithionone + Fluconazole
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Side Effects of Zinc Pyrithionone + Fluconazole
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Contra-indications of Zinc Pyrithionone + Fluconazole
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Special Precautions while taking Zinc Pyrithionone + Fluconazole
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Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
<13 Not recommended
Indications for Zinc Pyrithionone + Fluconazole
In stubborn and recurrent dandruff, seborrheic dermatitis
Interactions for Zinc Pyrithionone + Fluconazole
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Typical Dosage for Zinc Pyrithionone + Fluconazole
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Schedule of Zinc Pyrithionone + Fluconazole
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Storage Requirements for Zinc Pyrithionone + Fluconazole
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Effects of Missed Dosage of Zinc Pyrithionone + Fluconazole
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Effects of Overdose of Zinc Pyrithionone + Fluconazole
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About
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Mechanism of Action of
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Pharmacokinets of
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Onset of Action for
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Duration of Action for
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Half Life of
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Side Effects of
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Contra-indications of
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for
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Interactions for
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Typical Dosage for
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Schedule of
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Storage Requirements for
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Effects of Missed Dosage of
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Effects of Overdose of
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Fluconazole

About Fluconazole
A triazole derivative, A board range Antifungal.
Mechanism of Action of Fluconazole
Fluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis
Pharmacokinets of Fluconazole
Absorption: It is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes insignificant metabolism. Excretion: It is excreted mainly through urine.
Onset of Action for Fluconazole
N/A
Duration of Action for Fluconazole
1 day
Half Life of Fluconazole
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Side Effects of Fluconazole
1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Alopecia
6.Headache
7.Rash
8.Alteration in liver enzyme

Contra-indications of Fluconazole
1.Hypersensitivity to Fluconazole and other Azole antifungals
Special Precautions while taking Fluconazole
1. Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
CHILDREN below13:Use with caution.
NEONATES:contraindicated
Indications for Fluconazole
1.Oesophageal candidiasis
2.Oropharyngeal candidiasis
3.Vaginal candidiasis
4.Systemic candidiasis
5.Cryptococcal meningitis
6.Coccidioidomycosis
7.Histoplasmosis
8.Prophylaxis in bone marrow transplantation
9.Candidiasis in immunocompromised individuals
10.Peritonitis
Interactions for Fluconazole
Cimetidine: Decreased efficacy of fluconazole.
Cyclosporine: Increase in serum cyclosporine plasma concentration.
Hydrochlorothiazide: Reduction in renal clearance of fluconazole.
Phenytoin: Efficacy of phenytoin enhanced.
Rifampicin: Efficacy of fluconazole decreased, higher dosage required.
Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased.
Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time.

Typical Dosage for Fluconazole
Adult: 200 - 400 mg once daily
Systemic candidiasis: Maximum dose: 400 mg .The drug should be administered 2 more weeks after resolution of symptoms.
Oropharyngeal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily. The drug should be administered at least 14 days after resolution of symptoms.
Oesophageal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily and dose can be increased to 400 mg. The drug should be administered at least 14 days after resolution of symptoms.
Cryptococcal Meningitis: : Initial dose: 400 mg once daily followed by 200 mg once daily for 2 - 3 month until CSF culture is negative.
Vaginal candidiasis: 150 mg once daily
Peritonitis: 50 - 200 mg once daily.
Before bone marrow transplantation as prophylaxis:400 mg once daily for several days before transplantation and after 7 days after Neutrophil count rises above 1000 cells per cub.mm.
Candidiasis in immunocompromised individuals: 100 -200 mg once daily.
CHILDREN:
2 - 8 mg / kg body weight /day
Systemic candidiasis: 6 - 12 mg / kg body weight /day
Oropharyngeal candidiasis: Initial dose: 6 mg / kg body weight / day followed by 3 mg / kg body weight / day. The drug should be administered at least 14 days after resolution of symptoms.

Schedule of Fluconazole
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Storage Requirements for Fluconazole
The drug should be stored in room temperature. Keep away from moisture and sunlight.
Effects of Missed Dosage of Fluconazole
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.
Effects of Overdose of Fluconazole
Give supportive measures and treatment.

Home Delivery for Zinc Pyrithionone + Fluconazole in Your City

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Zinc Pyrithionone + Fluconazole is a generic medicine name and there are several brands available for it. Some of the brands for zinc pyrithionone + fluconazole might be better known than zinc pyrithionone + fluconazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zinc pyrithionone + fluconazole in stock, you can ask for one of the branded alternatives for zinc pyrithionone + fluconazole.