Vildagliptin + Metformin Pharmacology

Vildagliptin + Metformin

About Vildagliptin + Metformin
Mechanism of Action of Vildagliptin + Metformin
Pharmacokinets of Vildagliptin + Metformin
Onset of Action for Vildagliptin + Metformin
Duration of Action for Vildagliptin + Metformin
Half Life of Vildagliptin + Metformin
Side Effects of Vildagliptin + Metformin
1.Disturbances of the gut such as diarrhoea, nausea, vomiting or abdominal pain.
2.Loss of appetite.
6.Metallic taste.
Contra-indications of Vildagliptin + Metformin
1.Type 1 diabetes.
2.Diabetic keto-acidosis.
3.Diabetic pre-coma (due to ketoacidosis in severe and inadequately treated diabetes).
4.Decreased kidney function or kidney failure.
5.Decreased liver function.
63Heart failure.
7.People who have recently had a heart attack.
8.People with conditions that cause breathing to be ineffective, ie to not effectively oxygenate the blood or remove carbon dioxide from the lungs (respiratory failure).
9.People with reduced blood flow to vital internal organs (shock).
10.Severe infections or trauma.
12.Alcohol intoxication.
Special Precautions while taking Vildagliptin + Metformin
People taking ACE inhibitor medicines.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Not recommended
Indications for Vildagliptin + Metformin
Patients with type 2 diabetes whose blood sugar is not controlled by the maximum tolerated dose of metformin alone.
Interactions for Vildagliptin + Metformin
Typical Dosage for Vildagliptin + Metformin
Schedule of Vildagliptin + Metformin
Storage Requirements for Vildagliptin + Metformin
Effects of Missed Dosage of Vildagliptin + Metformin
Effects of Overdose of Vildagliptin + Metformin


Antidiabetic agent, Oral hypoglycaemic agent for type 2 diabetes
Mechanism of Action of VILDAGLIPTIN
Vildagliptin is a dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycaemic control by preventing DPP-4 from inactivating the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus prolonging incretin activity in response to ingestion of nutrients. This increases insulin sensitivity, decreases glucagon secretion and improves ?-cell function
Pharmacokinets of VILDAGLIPTIN
Absorption: Absorbed rapidly after oral administration
Metabolism: Metabolism is mainly by hydrolysis in kidney
Excretion: Excretion accounts for 85% in urine and 15% in faeces
Onset of Action for VILDAGLIPTIN
Duration of Action for VILDAGLIPTIN
2 to 3 hrs
Side Effects of VILDAGLIPTIN
2.Delayed gastric emptying
3.Nausea and Vomiting
Contra-indications of VILDAGLIPTIN
Hypersensitivity to these drug
Special Precautions while taking VILDAGLIPTIN
Renal Impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for VILDAGLIPTIN
Type 2 Diabetes Mellitus
Interactions for VILDAGLIPTIN
Increased risk of hypoglycaemia when used with other anti-diabetic agents
Typical Dosage for VILDAGLIPTIN
50 mg bid when used with metformin or a thiazolidinedione or 50 mg once daily in the morning when used with a sulfonylurea
Storage Requirements for VILDAGLIPTIN
Store in a well closed container below 30 degree celcius. Protect from moisture. Keep out of the reach of children
Effects of Missed Dosage of VILDAGLIPTIN
Effects of Overdose of VILDAGLIPTIN


About Metformin
Biguanide derivative, Oral anti-diabetic.
Mechanism of Action of Metformin
It is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.
Pharmacokinets of Metformin
Absorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.
Onset of Action for Metformin
Duration of Action for Metformin
6 to 8 hours
Half Life of Metformin
1.5 to 3hours
Side Effects of Metformin
1. Abdominal pain
2. Nausea
3. Vomiting
4. Anorexia
5. Metalic taste
6. Mild diarrhea
7. Tiredness
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
12. Diarrhoea
13. Flatulence
14. Dermatitis
15. Rashes.
Contra-indications of Metformin
1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
8. Alcoholics.
Special Precautions while taking Metformin
1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Metformin
Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise).
Interactions for Metformin
Typical Dosage for Metformin
Adults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable.
Schedule of Metformin
Storage Requirements for Metformin
Store at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of Metformin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Metformin
Provide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.

Home Delivery for Vildagliptin + Metformin in Your City

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Vildagliptin + Metformin is a generic medicine name and there are several brands available for it. Some of the brands for vildagliptin + metformin might be better known than vildagliptin + metformin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vildagliptin + metformin in stock, you can ask for one of the branded alternatives for vildagliptin + metformin.