Gammaglobulin Pharmacology


About Gammaglobulin
Protein(antibody) , passive immunizing agent, Immune globulin(Eg: hepatitis A prophylaxis).
Mechanism of Action of Gammaglobulin
This is an extract of human (donor) blood which contains antibodies to diseases e.g. hepatitis A, measles, mumps, and German measles (rubella)
Pharmacokinets of Gammaglobulin
Onset of Action for Gammaglobulin
Duration of Action for Gammaglobulin
Half Life of Gammaglobulin
Side Effects of Gammaglobulin
1. Rash
2. Fever (pyrexia)
3. Chills
4. Itching (pruritis)
5. Redness around injection site
6. Hardening of skin around injection site
7. Increased heart rate (tachycardia)
8. Malaise
9. Pain and swelling at site of injection
Contra-indications of Gammaglobulin
1. Hyper sensitivity to it
2. Vaccination with a live vaccine (e.g. oral polio, MMR) at the same time or in the previous 3 weeks
3. Immunoglobulin A (IgA) deficiency
4. Thrombocytopenia
5. Coagulation disorder
Special Precautions while taking Gammaglobulin
Use with caution in patients with a history of prior systemic allergic reactions following the administration of human immunoglobulin preparations.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Gammaglobulin
1. Preventing infection following burns injuries
2. Prevention of German measles following exposure in pregnancy
3. Prevention of Hepatitis A
4. Prevention of measles or reduction in measles symptoms following exposure in susceptible people 5. Reducing number and severity of infections in people with low levels of immunoglobulins in their blood
6. Agammaglobulinaemia/hypogammaglobulinaemia/dysgammaglobulinaemia
Interactions for Gammaglobulin
Typical Dosage for Gammaglobulin
Adults and children-
Hepatitis A:
Long term protection:0.06 mL/kg bodyweight
Short term protection: 0.03 mL/kg bodyweight
For prophylaxis long term, the injections should be given 5 monthly but serological checks should be made to assess if active immunity has developed.
The following doses of Normal Immunoglobulin are recommended for persons who plan
to travel in areas where hepatitis A is common
Length of stay <3 months- 0.03 mL/kg bodyweight
3 months or longer - 0.06 mL/kg bodyweight (repeat every 4-6 months)
Institutional contacts- 0.06 mL/kg bodyweight. Staff in institutions where hepatitis is endemic- A large dose (0.06 mL/kg bodyweight)
should be given at the time of employment, and this should be repeated at six-monthly
intervals if the risk persists.
Measles- 0.2 mL/kg bodyweight for prevention.
Poliomyelitis- 0.3 mL/kg bodyweight.
Hypogammaglobulinaemia- 0.6 mL/kg bodyweight at intervals of one month. An additional dose should be given during the first month of treatment
Schedule of Gammaglobulin
Storage Requirements for Gammaglobulin
Store at 2?C to 8?C (Refrigerate. Do not freeze). Protect from light
Effects of Missed Dosage of Gammaglobulin
Effects of Overdose of Gammaglobulin
Give symptomatic and supportive treatment

Home Delivery for Gammaglobulin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gammaglobulin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gammaglobulin and other medicines and health products. Home delivery services for gammaglobulin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gammaglobulin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gammaglobulin before they complete the sale. You can get this information while placing the order for gammaglobulin with the pharmacy.

Gammaglobulin is a generic medicine name and there are several brands available for it. Some of the brands for gammaglobulin might be better known than gammaglobulin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gammaglobulin in stock, you can ask for one of the branded alternatives for gammaglobulin.