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- Pharmacology For Amoxycillin + Clavulanic Acid
Amoxycillin + Clavulanic Acid Pharmacology
Amoxycillin + Clavulanic AcidAbout Amoxycillin + Clavulanic AcidN/AMechanism of Action of Amoxycillin + Clavulanic AcidN/APharmacokinets of Amoxycillin + Clavulanic AcidN/AOnset of Action for Amoxycillin + Clavulanic AcidN/ADuration of Action for Amoxycillin + Clavulanic AcidN/AHalf Life of Amoxycillin + Clavulanic AcidN/ASide Effects of Amoxycillin + Clavulanic AcidN/AContra-indications of Amoxycillin + Clavulanic AcidN/ASpecial Precautions while taking Amoxycillin + Clavulanic AcidN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Amoxycillin + Clavulanic Acid1.Respiratory tract infections
2.Urinary tract infections
7.Bone and joint infections
9.Ear, nose, throat infections
11. Skin and soft tissue infections
Interactions for Amoxycillin + Clavulanic AcidN/ATypical Dosage for Amoxycillin + Clavulanic AcidAdult: 1 - 2 tablet 3 times daily.
Amoxicillin 500 mg + Clavulanic acid 125 mg three times daily or
Amoxycillin 250 mg + Clavulanic acid 125 mg three times daily depending on the severity of infection
Schedule of Amoxycillin + Clavulanic AcidN/AStorage Requirements for Amoxycillin + Clavulanic AcidN/AEffects of Missed Dosage of Amoxycillin + Clavulanic AcidN/AEffects of Overdose of Amoxycillin + Clavulanic AcidN/A
AmoxycillinAbout AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
5.Respiratory tract infections
7.Soft tissue infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
Clavulanic acidAbout Clavulanic acidBeta-Lactamase Inhibitor, Antibiotic resistance reducer to penicillin group.Mechanism of Action of Clavulanic acidN/APharmacokinets of Clavulanic acidN/AOnset of Action for Clavulanic acidN/ADuration of Action for Clavulanic acidN/AHalf Life of Clavulanic acidN/ASide Effects of Clavulanic acidN/AContra-indications of Clavulanic acidN/ASpecial Precautions while taking Clavulanic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Clavulanic acidN/AInteractions for Clavulanic acidN/ATypical Dosage for Clavulanic acidN/ASchedule of Clavulanic acidN/AStorage Requirements for Clavulanic acidN/AEffects of Missed Dosage of Clavulanic acidN/AEffects of Overdose of Clavulanic acidN/A
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