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- Pharmacology For Amoxycillin + Dicloxacillin + Lactobacillus
Amoxycillin + Dicloxacillin + Lactobacillus Pharmacology
Amoxycillin + Dicloxacillin + LactobacillusAbout Amoxycillin + Dicloxacillin + LactobacillusN/AMechanism of Action of Amoxycillin + Dicloxacillin + LactobacillusN/APharmacokinets of Amoxycillin + Dicloxacillin + LactobacillusN/AOnset of Action for Amoxycillin + Dicloxacillin + LactobacillusN/ADuration of Action for Amoxycillin + Dicloxacillin + LactobacillusN/AHalf Life of Amoxycillin + Dicloxacillin + LactobacillusN/ASide Effects of Amoxycillin + Dicloxacillin + LactobacillusN/AContra-indications of Amoxycillin + Dicloxacillin + LactobacillusN/ASpecial Precautions while taking Amoxycillin + Dicloxacillin + LactobacillusN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin + Dicloxacillin + Lactobacillus1.Respiratory tract infections:Tonsillar abscess, otitis media, suppurative sinus infection, acute chronic bronchitis, bronchiectasis, bronchopneumonia, pleurisy, empyema, lung abscess, emphysema, bronchiolitis.
2.Urinary tract infections:Acute and chronic pyelonephritis, cystitis, urethritis.
3.Skin and soft tissue infections:Recurrent boils, carbuncles, impetigo, cellulitis and other infected dermatoses.
4.Bone infections:Osteomyelitis and septic arthritis.
5.Serious infections:Septicemia, bacterial endocarditis, brain abscess and bacterial meningitis.
Interactions for Amoxycillin + Dicloxacillin + LactobacillusN/ATypical Dosage for Amoxycillin + Dicloxacillin + LactobacillusThe dosage differs, depending on the type, site and severity of infections. The usual dosage is one capsule, three to four times daily.
In patients with severe renal impairment, the dosage should be modified by increasing the intervals between doses. With a creatinine clearance between 10 and 50 mL/min, the dosing interval can be up to 12 hours. If the clearance is less than 10 mL/min, the interval can be 16 hours.
Schedule of Amoxycillin + Dicloxacillin + LactobacillusN/AStorage Requirements for Amoxycillin + Dicloxacillin + LactobacillusN/AEffects of Missed Dosage of Amoxycillin + Dicloxacillin + LactobacillusN/AEffects of Overdose of Amoxycillin + Dicloxacillin + LactobacillusN/A
AmoxycillinAbout AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
5.Respiratory tract infections
7.Soft tissue infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
DicloxacillinAbout DicloxacillinA semisynthetic narrow spectrum beta-lactam antibiotic ofpenicillin class, Penicillinase resistant Antibiotic.Mechanism of Action of DicloxacillinLike other ?-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.Pharmacokinets of DicloxacillinAbsorption :Absorption after oral administration is rapid but incomplete,food delays absorption
Distribution: widespread, highest in kidneys & liver, CSF low
Protein Binding: 96%
Metabolism: hepatic CYP3A4
Excretion: renal, feces
Onset of Action for DicloxacillinN/ADuration of Action for DicloxacillinN/AHalf Life of Dicloxacillin0.7 hourSide Effects of Dicloxacillin1.Diarrhoea
5.Pain and inflammation at injection site
6.Superinfection (including candidiasis)
8.Transient increases in liver enzymes and bilirubin
Contra-indications of Dicloxacillin1.Hypersensitivity to penicillins,cephalosporins, carbapenems
2.Not to be used in the eye
3.Cholestatic hepatitis associated with the use of dicloxacillin
Special Precautions while taking Dicloxacillin1.Renal impairment
Pregnancy Related InformationUse with caution Old Age Related InformationUse with caution Breast Feeding Related InformationExcreted in breast milk, use cautionChildren Related InformationN/AIndications for Dicloxacillin1.Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
2.Staphylococcal skin infections and cellulitis ? including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
4.Osteomyelitis, septic arthritis, throat infections, streptococcus
6.Empirical treatment for endocarditis
Interactions for Dicloxacillin1.Dicloxacillin decreases anticoagulant effect of warfarin
2.Probenecid prolongs T1/2 of dicloxacillin
3.Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Typical Dosage for DicloxacillinAdult:250 to 500mg in every 6 hours
Paediatric:<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Schedule of DicloxacillinN/AStorage Requirements for DicloxacillinN/AEffects of Missed Dosage of DicloxacillinN/AEffects of Overdose of DicloxacillinN/A
LactobacillusAbout LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatment
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