Armodafinil Pharmacology

Armodafinil

About Armodafinil
(?)-(R)-enantiomer of the racemic drug modafinil
Mechanism of Action of Armodafinil
The mechanism of armodafinil is unknown but it appears to exert its stimulant effects by reducing GABA-mediated neurotransmission.
Pharmacokinets of Armodafinil
Absorption:Readily absorbed after oral administration. C max approximately 2 h. Food delays T ma approximately 2 to 4 h.
Distribution:Vd is approximately 42 L. Binding to plasma protein, primarily albumin, is 60%.
Metabolism: Hepatic
Elimination: Mainly eliminated by hepatic metabolism with less than 10% excreted in the urine.
Onset of Action for Armodafinil
N/A
Duration of Action for Armodafinil
N/A
Half Life of Armodafinil
15hrs
Side Effects of Armodafinil
1.Headache
2.Nausea
3.Insomnia
4.Lack of appetite
5.Dizziness
6.Agitation
7.Anxiety
8.High blood pressure
Contra-indications of Armodafinil
Hypersensitivity to modafinil or armodafinil or any component of the product.
Special Precautions while taking Armodafinil
1.History of psychosis, depression, mania.
2.Discontinue use if there is any sign of rash or hypersensitivity reaction.
3.Increase monitoring in patients with hypertension.
4.Hepatic and renal impairment.
5.Tourette's syndrome.
6.May impair ability to drive or operate machinery.
7.Because of psychoactive and euphoric effects, armodafinil has potential for abuse.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution;dose reduction may be needed
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended below 16 yrs
Indications for Armodafinil
Improve wakefulness in patients with excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome, narcolepsy, and shift work sleep disorder.
Interactions for Armodafinil
1.Drugs metabolized by CYP2C19 (eg, diazepam, omeprazole, phenytoin, propranolol) :Plasma concentration may be elevated by armodafinil, increasing the risk of adverse reactions. Dosage reduction of these agents may be necessary.
2.Drugs metabolized by CYP3A4/5 (eg, cyclosporine, ethinyl estradiol, midazolam, triazolam) :Plasma concentrations may be reduced by armodafinil, decreasing efficacy.
3.Potent inducers of CYP3A4/5 (eg, carbamazepine, phenobarbital, rifampin):Armodafinil concentrations may be reduced, decreasing efficacy.
4.Potent inhibitors of CYP3A4/5 (eg, erythromycin, ketoconazole) :Armodafinil concentrations may be elevated, increasing the risk of adverse reactions.
Typical Dosage for Armodafinil
Obstructive Sleep Apnea/Hypopnea Syndrome and Narcolepsy Adults and Children older than 16 yr of age :PO 150 or 250 mg as a single dose in the morning.
Shift Work Sleep Disorder Adults and Children older than 16 yr of age:PO 150 mg daily approximately 1 h prior to the start of work shift.
Schedule of Armodafinil
N/A
Storage Requirements for Armodafinil
Store at 68? to 77?F.
Effects of Missed Dosage of Armodafinil
Take it as soon as remember. If it is near the time of the next dose, skip the missed dose and resume usual dosing schedule. Do not double the dose to catch up. Do not take missed doses close to bedtime because this drug can interfere with your sleep.
Effects of Overdose of Armodafinil
Symptoms: Agitation, irritability, aggressiveness, confusion, nervousness, tremor, insomnia, palpitations, elevations in haemodynamic parameters. Management: Symptomatic and supportive. Monitor cardiac function.

Home Delivery for Armodafinil in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including armodafinil.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for armodafinil and other medicines and health products. Home delivery services for armodafinil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take armodafinil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for armodafinil before they complete the sale. You can get this information while placing the order for armodafinil with the pharmacy.

Armodafinil is a generic medicine name and there are several brands available for it. Some of the brands for armodafinil might be better known than armodafinil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have armodafinil in stock, you can ask for one of the branded alternatives for armodafinil.