Amoxycillin + Cloxacillin Pharmacology

Amoxycillin + Cloxacillin

About Amoxycillin + Cloxacillin
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Mechanism of Action of Amoxycillin + Cloxacillin
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Pharmacokinets of Amoxycillin + Cloxacillin
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Onset of Action for Amoxycillin + Cloxacillin
N/A
Duration of Action for Amoxycillin + Cloxacillin
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Half Life of Amoxycillin + Cloxacillin
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Side Effects of Amoxycillin + Cloxacillin
N/A
Contra-indications of Amoxycillin + Cloxacillin
N/A
Special Precautions while taking Amoxycillin + Cloxacillin
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Amoxycillin + Cloxacillin
1.Respiratory tract infection
2.Otitis media
3.Sinusitis
4.Skin infections
5.Urinary tract infections
6.ENT infections
7.Osteomyelitis
8.Septicaemia
9.Bacterial endocarditis
10.Meningitis
11.Gonorrhea
12.Typhoid
13.Bone and joint infections
Interactions for Amoxycillin + Cloxacillin
N/A
Typical Dosage for Amoxycillin + Cloxacillin
Adult: 1 - 2 tablet 3 times daily depending on the severity of infection
Amoxicillin 250 mg + Cloxacillin 250 mg or
Amoxycillin 500 mg + Cloxacillin 500mg
Children:
Amoxicillin 125 mg + Cloxacillin 125 mg three times daily or
Amoxycillin 250 mg + Cloxacillin 250 mg three times daily daily depending on the severity of infection
Schedule of Amoxycillin + Cloxacillin
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Storage Requirements for Amoxycillin + Cloxacillin
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Effects of Missed Dosage of Amoxycillin + Cloxacillin
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Effects of Overdose of Amoxycillin + Cloxacillin
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Amoxycillin

About Amoxycillin
Semisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.
Mechanism of Action of Amoxycillin
Amoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.
Pharmacokinets of Amoxycillin
Absorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin
60 -120 minutes
Duration of Action for Amoxycillin
6-8 hours
Half Life of Amoxycillin
60 minutes
Side Effects of Amoxycillin
1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of Amoxycillin
Hypersensitivity to Amoxicillin and other Penicillins.
Special Precautions while taking Amoxycillin
1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Amoxycillin
1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for Amoxycillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.
Typical Dosage for Amoxycillin
ADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of Amoxycillin
H
Storage Requirements for Amoxycillin
It should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Amoxycillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose
Effects of Overdose of Amoxycillin
Give supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.

Cloxacillin

About Cloxacillin
It is a Penicillinase resistant Penicillin, Penicillin derived antibiotic.
Mechanism of Action of Cloxacillin
Cloxacillin is a bactericidal drug. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. In addition to this it is not degraded by penicillinase enzyme and therefore it can be useful against penicillinase producing bacteria also.
Pharmacokinets of Cloxacillin
Absorption .It is readily absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through urine and small amount excreted through breast milk.
Onset of Action for Cloxacillin
30-60 minutes
Duration of Action for Cloxacillin
About 6 hours
Half Life of Cloxacillin
30 minutes
Side Effects of Cloxacillin
1.Anaphylaxis
2.Rash
3.Urticaria
4.Thrombocytopenia
5.Seizure
Contra-indications of Cloxacillin
Hypersensitive to Cloxacillin or other Penicillins.
Special Precautions while taking Cloxacillin
1.Heart failure
2.Uremia
3.Hypokalemia
4 Bleeding tendencies
5.Meningitis
6.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Cloxacillin
1.Urinary tract infections
2.Respiratory tract infections
3.Septicaemia
4.Osteomyelitis
5.Endocarditis
6.Pneumonia
7.Sinusitis
8.Bronchiectasis
Interactions for Cloxacillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Atenolol: Bio-availability of atenolol reduced.
Allopurinol: Increases risk of cloxacillin induced skin rash.
Probenecid: Increases blood levels.
Erythromycin & Tetracyclines: Reduce efficacy.
Clavulanic Acid: Synergy.
Food: Interferes with absorption
Typical Dosage for Cloxacillin
ADULT
1 - 2 g daily in four divided dose depending on the severity of infection
CHILDREN
50 - 100 mg/kg/day in four divided dose depending on the severity of infection
Schedule of Cloxacillin
H
Storage Requirements for Cloxacillin
The vial should be stored in room temperature away from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Cloxacillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose
Effects of Overdose of Cloxacillin
Give supportive measures and symptomatic treatment. Absorption of drug can be reduced by gastric lavage or induction of emesis

Home Delivery for Amoxycillin + Cloxacillin in Your City

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Amoxycillin + Cloxacillin is a generic medicine name and there are several brands available for it. Some of the brands for amoxycillin + cloxacillin might be better known than amoxycillin + cloxacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amoxycillin + cloxacillin in stock, you can ask for one of the branded alternatives for amoxycillin + cloxacillin.