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- Pharmacology For Amoxycillin + Cloxacillin
Amoxycillin + Cloxacillin Pharmacology
Amoxycillin + CloxacillinAbout Amoxycillin + CloxacillinN/AMechanism of Action of Amoxycillin + CloxacillinN/APharmacokinets of Amoxycillin + CloxacillinN/AOnset of Action for Amoxycillin + CloxacillinN/ADuration of Action for Amoxycillin + CloxacillinN/AHalf Life of Amoxycillin + CloxacillinN/ASide Effects of Amoxycillin + CloxacillinN/AContra-indications of Amoxycillin + CloxacillinN/ASpecial Precautions while taking Amoxycillin + CloxacillinN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Amoxycillin + Cloxacillin1.Respiratory tract infection
5.Urinary tract infections
13.Bone and joint infections
Interactions for Amoxycillin + CloxacillinN/ATypical Dosage for Amoxycillin + CloxacillinAdult: 1 - 2 tablet 3 times daily depending on the severity of infection
Amoxicillin 250 mg + Cloxacillin 250 mg or
Amoxycillin 500 mg + Cloxacillin 500mg
Amoxicillin 125 mg + Cloxacillin 125 mg three times daily or
Amoxycillin 250 mg + Cloxacillin 250 mg three times daily daily depending on the severity of infection
Schedule of Amoxycillin + CloxacillinN/AStorage Requirements for Amoxycillin + CloxacillinN/AEffects of Missed Dosage of Amoxycillin + CloxacillinN/AEffects of Overdose of Amoxycillin + CloxacillinN/A
AmoxycillinAbout AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
5.Respiratory tract infections
7.Soft tissue infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
CloxacillinAbout CloxacillinIt is a Penicillinase resistant Penicillin, Penicillin derived antibiotic.Mechanism of Action of CloxacillinCloxacillin is a bactericidal drug. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. In addition to this it is not degraded by penicillinase enzyme and therefore it can be useful against penicillinase producing bacteria also.Pharmacokinets of CloxacillinAbsorption .It is readily absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through urine and small amount excreted through breast milk.Onset of Action for Cloxacillin30-60 minutesDuration of Action for CloxacillinAbout 6 hoursHalf Life of Cloxacillin30 minutesSide Effects of Cloxacillin1.Anaphylaxis
Contra-indications of CloxacillinHypersensitive to Cloxacillin or other Penicillins.Special Precautions while taking Cloxacillin1.Heart failure
4 Bleeding tendencies
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cloxacillin1.Urinary tract infections
2.Respiratory tract infections
Interactions for CloxacillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Atenolol: Bio-availability of atenolol reduced.
Allopurinol: Increases risk of cloxacillin induced skin rash.
Probenecid: Increases blood levels.
Erythromycin & Tetracyclines: Reduce efficacy.
Clavulanic Acid: Synergy.
Food: Interferes with absorptionTypical Dosage for CloxacillinADULT
1 - 2 g daily in four divided dose depending on the severity of infection
50 - 100 mg/kg/day in four divided dose depending on the severity of infection
Schedule of CloxacillinHStorage Requirements for CloxacillinThe vial should be stored in room temperature away from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of CloxacillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of CloxacillinGive supportive measures and symptomatic treatment. Absorption of drug can be reduced by gastric lavage or induction of emesis
Home Delivery for Amoxycillin + Cloxacillin in Your City
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Amoxycillin + Cloxacillin is a generic medicine name and there are several brands available for it. Some of the brands for amoxycillin + cloxacillin might be better known than amoxycillin + cloxacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amoxycillin + cloxacillin in stock, you can ask for one of the branded alternatives for amoxycillin + cloxacillin.