Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid Pharmacology

Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid

About Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Mechanism of Action of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Pharmacokinets of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Onset of Action for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Duration of Action for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Half Life of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Side Effects of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Contra-indications of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Special Precautions while taking Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Pregnancy Related Information
May be used
Old Age Related Information
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Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
1.Anaemia
2.Premenstrual syndrome
3.Iron deficiency syndrome
4.Pregnancy supplement
Interactions for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Typical Dosage for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Schedule of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Storage Requirements for Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Effects of Missed Dosage of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Effects of Overdose of Iron (Ferrous Ascorbate) + Methylcobalamin + Folic Acid
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Iron (Ferrous ascorbate)

About Iron (Ferrous ascorbate)
Fe II Salt of iron,oral iron formulation ,antianaemic,heamatinic.
Mechanism of Action of Iron (Ferrous ascorbate)
Addition of ascorbic acid converts the ferric form to ferrous form thus making it absorbable from duodenum and upper jejunum, resulting in considerable enhancement of the absorption of iron. It has been demonstrated that Fe(II) ascorbate is less easily oxidized than Fe(II) in ferrous sulphate. Absorption of ferrous ascorbate averaged 52% higher than ferrous sulphate in subjects with ID. (Marx et al., 1982) Thus when administered as ferrous ascorbate, Fe(II) salt is more resistant to oxidation at alkaline pH,delivers maximum amount of ferrous iron to the duodenal brush border and at the same time produces minimum GI adverse effects.
Pharmacokinets of Iron (Ferrous ascorbate)
1.Absorption:Increased in iron deficiency anaemia
2.Distribution:Transported in a transferring bound form to bone marrow
3.Elimination:Excretion is minimal
Onset of Action for Iron (Ferrous ascorbate)
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Duration of Action for Iron (Ferrous ascorbate)
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Half Life of Iron (Ferrous ascorbate)
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Side Effects of Iron (Ferrous ascorbate)
1.Nausea
2.Vomiting
3.Constipation
4.Diarrhea
5.Abdominal pain
Contra-indications of Iron (Ferrous ascorbate)
1.Hyper sensitivity
2.Haemolytic anaemia unless iron deficiency anaemia is present
3.Haemochromatosis
4.Haemosiderosis
5.Peptic ulcer
6.Regional enteritis
7.Ulcerative colitis
8.Those receiving repeated blood transfution
Special Precautions while taking Iron (Ferrous ascorbate)
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Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Iron (Ferrous ascorbate)
Prevention and treatment of Iron Deficiency Anemia in pregnant women and children.
Interactions for Iron (Ferrous ascorbate)
N/A
Typical Dosage for Iron (Ferrous ascorbate)
Ferrous ascorbate equivalent to 100 mg elemental iron is used for the treatment of Iron Deficiency Anemia in pregnancy and 30 to 60 mg is used as a prophylaxis for iron deficiency anemia in pregnancy, and also for treatment of iron deficiency anemia in children.
Schedule of Iron (Ferrous ascorbate)
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Storage Requirements for Iron (Ferrous ascorbate)
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Effects of Missed Dosage of Iron (Ferrous ascorbate)
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Effects of Overdose of Iron (Ferrous ascorbate)
Symptoms: Nausea, vomiting, abdominal pain, diarrhea, haematemesis and rectal bleeding. Hypotension, coma and hepatocellular necrosis may occur later.

Treatment: Empty stomach contents by gastric lavage within 1 hr of ingestion. In severe toxicity, IV desferrioxamine may be given. Whole bowel irrigation may also be considered in severe poisoning.

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Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
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Contra-indications of Folic Acid
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Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

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