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- Pharmacology For Ketorolac + Ofloxacin (Eye preparation)
Ketorolac + Ofloxacin (Eye preparation) Pharmacology
Ketorolac + Ofloxacin (Eye preparation)
About Ketorolac + Ofloxacin (Eye preparation)N/AMechanism of Action of Ketorolac + Ofloxacin (Eye preparation)N/APharmacokinets of Ketorolac + Ofloxacin (Eye preparation)N/AOnset of Action for Ketorolac + Ofloxacin (Eye preparation)N/ADuration of Action for Ketorolac + Ofloxacin (Eye preparation)N/AHalf Life of Ketorolac + Ofloxacin (Eye preparation)N/ASide Effects of Ketorolac + Ofloxacin (Eye preparation)N/AContra-indications of Ketorolac + Ofloxacin (Eye preparation)N/ASpecial Precautions while taking Ketorolac + Ofloxacin (Eye preparation)N/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated in children younger than 3 years oldIndications for Ketorolac + Ofloxacin (Eye preparation)1.Ketorolac ophthalmic solution is indicated for the treatment of post-operative inflammation. (Ocular surgery).
2.Seasonal Allergic Conjunctivitis .
3.To prevent ocular itching.
4.Post operative ocular inflammation and pain.
5.To reduce Bacterial Keratit.
Interactions for Ketorolac + Ofloxacin (Eye preparation)N/ATypical Dosage for Ketorolac + Ofloxacin (Eye preparation)One drop of ophthalmic solution should be applied to the affected eye(s) four times daily beginning 24 hours after cataract surgery and continuing through the first 2 weeks of the post-operative period.Schedule of Ketorolac + Ofloxacin (Eye preparation)N/AStorage Requirements for Ketorolac + Ofloxacin (Eye preparation)N/AEffects of Missed Dosage of Ketorolac + Ofloxacin (Eye preparation)N/AEffects of Overdose of Ketorolac + Ofloxacin (Eye preparation)N/AKetorolac
About KetorolacNSAID, heterocyclic acetic acid derivative, Analgesic,antipyretic,antiinflammatory.Mechanism of Action of KetorolacThis Non Steroidal Anti Inflammatory Drug`s peripheral analgesics action is by the reduction of the prostaglandin synthesis which mediates many of the inflammatory changes and fever at that time. Prostaglandin synthesis is reduced due to its cyclo oxygenase inhibition. At higher concentration it reduce production of super oxide radicals, induce apoptosis, inhibit the expression of adhesion molecules, decrease nitric oxide synthase , reduce pro inflammatory cytokines, modify lymphocyte activity, and alter cellular membrane functions.Pharmacokinets of KetorolacAbsorption-Absorbed rapidly after oral, i.v. and i.m. administration.
Distribution- Widely distributed in the body. 99% bound to the plasma proteins.
Metabolism- It is metabolized in liver by glucucoronidation.
Excretion-90% is excreted through urine and rest in feces. The rate of elimination is reduced in the elderly and in patients with renal failure.
Onset of Action for KetorolacFor I.V. there is rapid onset of action
In the case of I.M. it takes 10 minutes
After oral administration it takes ? to 1 hr
Duration of Action for Ketorolac6 to 8 hrsHalf Life of Ketorolac5 - 7 hrsSide Effects of Ketorolac1. Nausea
2. Drowsiness
3. Dizziness
4. Headache
5. Syncope
6. Transient scalp tingling
7. Orthostatic hypotension
8. Ventricular arrhythmias
9. Nasal stuffiness
10. Broncho spasm
11. Vomiting
12. Diarrhea
13. Muscle spasm
14. Toxic myopathy
15. Dry mouth
16. Ulcer
17. Gastric irritation
18. Oedema
19. Dry mouth
Contra-indications of Ketorolac1. Hypersensitivity to this drug
2. Peptic ulcer
3. As a prophylactic analgesic before surgery; pregnancy and lactation
5. In elderly patient there is usually hepatic or renal dysfunction
6. Coagulation disorder
Special Precautions while taking Ketorolac1. Hepatic dysfunction
2. Renal dysfunction and in to be used with caution
3. GI disease
4. Bleeding disorders
5. Patients with hypersensitivity to other Non Steroidal Anti Inflammatory Drugs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Ketorolac1. It is used to severe and moderate pain frequently in post operative and acute musculoskeletal pain
2. For routine obstetrics analgesia
3. For renal colic, migraine and pain due to bony metastasis
4. Migraine
5. Acute gout
Interactions for KetorolacAnticoagulants: May prolong prothrombin time.
Beta blockers: Antihypertensive effect may be impaired.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Lithium: Serum lithium levels may be increased resulting in toxicity.
Hydantoins: Serum hydantoins levels resulting in increased efficacy and toxic effects.
Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression, nephrotoxicity) increased.
Aspirin: Plasma concentration of ketorolac may be decreased and may increase the incidence of GI effects.Typical Dosage for KetorolacFor Injection-
Adults-Initially 60mg i.m. or 30mg i.v. as a single dose, or 30 mg i.m or i.v. every 6 hrs. In the case of renal impaired patient, initially 30mg i.m .or 15mg i.v. as a single doses or multiple doses of 15mg i.m. or i.v.every 6 hrs.
For oral-
Adults- 20mg as a single dose followed by 10mg every 4 to 6 hrs. In the case of renal impaired patients 10mg as a single dose, followed by 10mg every 4 to 6 hrs.
Schedule of KetorolacHStorage Requirements for KetorolacStore at controlled room temperature.Effects of Missed Dosage of KetorolacTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of KetorolacTake more fluids to dilute the over dosage. Give symptomatic and supportive treatment.About N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/AHome Delivery for Ketorolac + Ofloxacin (Eye preparation) in Your City
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Ketorolac + Ofloxacin (Eye preparation) is a generic medicine name and there are several brands available for it. Some of the brands for ketorolac + ofloxacin (eye preparation) might be better known than ketorolac + ofloxacin (eye preparation) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ketorolac + ofloxacin (eye preparation) in stock, you can ask for one of the branded alternatives for ketorolac + ofloxacin (eye preparation).
