Metformin + Nateglinide Pharmacology

Metformin + Nateglinide

About Metformin + Nateglinide
N/A
Mechanism of Action of Metformin + Nateglinide
N/A
Pharmacokinets of Metformin + Nateglinide
N/A
Onset of Action for Metformin + Nateglinide
N/A
Duration of Action for Metformin + Nateglinide
N/A
Half Life of Metformin + Nateglinide
N/A
Side Effects of Metformin + Nateglinide
N/A
Contra-indications of Metformin + Nateglinide
N/A
Special Precautions while taking Metformin + Nateglinide
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Metformin + Nateglinide
Type 2 diabetes mellitus
Interactions for Metformin + Nateglinide
N/A
Typical Dosage for Metformin + Nateglinide
N/A
Schedule of Metformin + Nateglinide
N/A
Storage Requirements for Metformin + Nateglinide
N/A
Effects of Missed Dosage of Metformin + Nateglinide
N/A
Effects of Overdose of Metformin + Nateglinide
N/A

Metformin

About Metformin
Biguanide derivative, Oral anti-diabetic.
Mechanism of Action of Metformin
It is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.
Pharmacokinets of Metformin
Absorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.
Onset of Action for Metformin
N/A
Duration of Action for Metformin
6 to 8 hours
Half Life of Metformin
1.5 to 3hours
Side Effects of Metformin
1. Abdominal pain
2. Nausea
3. Vomiting
4. Anorexia
5. Metalic taste
6. Mild diarrhea
7. Tiredness
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
12. Diarrhoea
13. Flatulence
14. Dermatitis
15. Rashes.
Contra-indications of Metformin
1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
8. Alcoholics.
Special Precautions while taking Metformin
1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Metformin
Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise).
Interactions for Metformin
N/A
Typical Dosage for Metformin
Adults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable.
Schedule of Metformin
G
Storage Requirements for Metformin
Store at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of Metformin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Metformin
Provide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.

Nateglinide

About Nateglinide
Meglitinide Derivative, Oral Antidiabetic Agent.
Mechanism of Action of Nateglinide
It is a quick and short acting antidiabetic drug which exerts it`s action by stimulating insulin release from ?-cells of pancreas. It acts by binding to sulfonylurea receptor and to other distinct receptors and closes ATP dependent potassium channels and thus causes depolarization. This depolarization of pancreatic ? cells causes opening of Ca channels and increased Ca influx which induces insulin secretion.
Pharmacokinets of Nateglinide
Absorption: Well absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in to active metabolites, Excretion: Excreted mainly through urine as metabolites.
Onset of Action for Nateglinide
N/A
Duration of Action for Nateglinide
2 to 3 hours
Half Life of Nateglinide
1.5 hours
Side Effects of Nateglinide
1.Flu like symptoms
2.Dizziness
3.Arthralgia
4.Weight gain
5.Nausea
6.Diarrhoea
7.Back pain
8.Increased uric acid
9.Bronchitis
12.Sinusitis
13.Upper respiratory tract infections
14.Accidental injuries
15.Mild hypoglycaemia
Contra-indications of Nateglinide
1. Hypersensitivity to the drug
2. Type-1 diabetes mellitus
3. Diabetic ketoacidosis
Special Precautions while taking Nateglinide
1.Hepatic impairment
2.Malnourished and deliberate individuals
3.After severe exercise
4.Along with alcohol
5.Along with other glucose lowering drugs
6.Loss of control of blood glucose may occur with drug when patient is exposed to stress such as fever, trauma, infection, or surgery. In such situations stop the Nateglinide and administer insulin
7.Trauma
8.Coma
9.Myocardial infarction
10.Adrenal insufficiency
11.Pituitary insufficiency
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Nateglinide
1. Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise)
Interactions for Nateglinide
Nsaids, salicylates, MAOIs, and non selective beta-adrenergic blocking agents: May potentiate the hypoglycaemic effects.
Thiazides, corticosteroids, thyroxine and sympathomimetics: May reduce the hypoglycaemic effects.
Typical Dosage for Nateglinide
Oral: Starts with 60mg thrice daily; taken 10 to 30 minutes before each main meals. Increases the dose based on patient`s response.
Maximum dose: 180mg thrice daily.

Schedule of Nateglinide
N/A
Storage Requirements for Nateglinide
Store at room temperature at a range of 15 to 30 degree C.in a well closed container. Protect from moisture. Keep out of reach of children.
Effects of Missed Dosage of Nateglinide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nateglinide
Provide symptomatic treatment and supportive measures. Treat mild hypoglycaemia with glucose and also; dosage or meal pattern adjustment. Closely monitor patient for at least 24 to 48 hours. Treat severe hypoglycaemia with neurological manifestations with I.V. dextrose 50% solution followed by a continuous infusion of glucose 10%solution. Carefully monitor blood sugar levels.

Home Delivery for Metformin + Nateglinide in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for metformin + nateglinide and other medicines and health products. Home delivery services for metformin + nateglinide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take metformin + nateglinide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for metformin + nateglinide before they complete the sale. You can get this information while placing the order for metformin + nateglinide with the pharmacy.

Metformin + Nateglinide is a generic medicine name and there are several brands available for it. Some of the brands for metformin + nateglinide might be better known than metformin + nateglinide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have metformin + nateglinide in stock, you can ask for one of the branded alternatives for metformin + nateglinide.