Asenapine Pharmacology
Asenapine
Distribution:Widely distributed, 95% bound to plasma proteins.
Metabolism:Hepatic
Elimination:Elimination is 50% in urine and 40% in feces
2.Movement disorder
3.Weight increased
4.Drowsiness
5.Constipation
6.Dry mouth
7.Increased saliva
8.Stomach discomfort
9.Vomiting
10.Fatigue
11.Irritability
12.Increased appetite
13.Weakness
14.Dizziness
15.Sleeplessness
16.High blood pressure
2.Severe liver problems
3.Heart diseases
4.Who are taking antiarrhythmic, antipsychotic, phenothiazine, quinolone drugs
2.Do not drive a car or operate machinery and get up slowly from bed while taking this medication.
3.Avoid alcohol consumption.
4.Avoid abrupt withdrawal; withdraw gradually.
5.Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating.
6.Avoid contact with people who have infections.
7.Drink adequate fluid; otherwise it may lead to dehydration.
2.Schizophrenia
2.QT interval prolonging medications:Antiarrhythmics-class IA,class III,antibiotics (eg, gatifloxacin, moxifloxacin); antipsychotics (eg, chlorpromazine, thioridazine, ziprasidone):Additive effects on QT interval prolongation may increase the risk of life-threatening arrhythmias, including torsades de pointes. Avoid this combination.
3.Antihypertensive agents:Because of alpha-1 adrenergic antagonism by asenapine, the effect of certain antihypertensive agents may be enhanced. Monitor BP and adjust the dose of the antihypertensive agent as needed.
4.Dextromethorphan :Plasma concentrations of dextromethorphan may be decreased. Use with caution.
5.Fluvoxamine, imipramine :Asenapine plasma concentrations may be elevated, increasing the pharmacologic effects and risk of adverse reactions. Use with caution.
6.Paroxetine :Asenapine plasma concentrations may be decreased, while paroxetine plasma concentrations may be increased. Use with caution.
Adults:5 mg twice daily initially in combination with lithium or valproate. Increase to 10 mg twice daily depending on the clinical response and tolerability.
Bipolar Mania Monotherapy:
Adults:10 mg twice daily initially. Dosage may be decreased to 5 mg twice daily if there are adverse effects.
Schizophrenia:
Adults:5 mg twice daily. Increase up to 10 mg twice daily after 1 wk based on tolerability.
Treatment: No specific antidote,give supportive care to the patient.
Home Delivery for Asenapine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including asenapine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for asenapine and other medicines and health products. Home delivery services for asenapine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take asenapine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for asenapine before they complete the sale. You can get this information while placing the order for asenapine with the pharmacy.
Asenapine is a generic medicine name and there are several brands available for it. Some of the brands for asenapine might be better known than asenapine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have asenapine in stock, you can ask for one of the branded alternatives for asenapine.
