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- Pharmacology For Iron (Sodium Feredetate) + Folic Acid + Vitamin B12
Iron (Sodium Feredetate) + Folic Acid + Vitamin B12 Pharmacology
Iron (Sodium Feredetate) + Folic Acid + Vitamin B12
About Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AMechanism of Action of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/APharmacokinets of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AOnset of Action for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/ADuration of Action for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AHalf Life of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/ASide Effects of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AContra-indications of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/ASpecial Precautions while taking Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12Iron Deficiency Anemia due to:
1.Pregnancy
2.Chronic blood loss
3.Surgery
4.Worm infestation
5.Blood loss due to menstruation
Interactions for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/ATypical Dosage for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/ASchedule of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AStorage Requirements for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AEffects of Missed Dosage of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AEffects of Overdose of Iron (Sodium Feredetate) + Folic Acid + Vitamin B12N/AIron (Sodium Feredetate)
About Iron (Sodium Feredetate)Oral iron preparation, Antianemic,hematinicMechanism of Action of Iron (Sodium Feredetate)The iron preparation Sodium feredate (sodium iron edetate) is not an iron salt. It is an unionised form. It is not astringent and does not discolour teeth. Sodium feredetate breaks down within the gastrointestinal tract and release elemental iron, which is then absorbed.
Iron formulations exert haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
Pharmacokinets of Iron (Sodium Feredetate)Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.Onset of Action for Iron (Sodium Feredetate)N/ADuration of Action for Iron (Sodium Feredetate)N/AHalf Life of Iron (Sodium Feredetate)N/ASide Effects of Iron (Sodium Feredetate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
Contra-indications of Iron (Sodium Feredetate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Sodium Feredetate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Sodium Feredetate)1. Iron deficiency
2. Iron deficiency anaemia
Interactions for Iron (Sodium Feredetate)N/ATypical Dosage for Iron (Sodium Feredetate)Oral: Dose up to 1.42 g daily (equivalent to up to about 205 mg of iron daily).Schedule of Iron (Sodium Feredetate)HStorage Requirements for Iron (Sodium Feredetate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Sodium Feredetate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Sodium Feredetate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl. Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.About N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/AHome Delivery for Iron (Sodium Feredetate) + Folic Acid + Vitamin B12 in Your City
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