Mezlocillin Pharmacology

Mezlocillin

About Mezlocillin

A extended -spectrum beta-lactam penicillin,acylamino pencillin, Penicillin antibiotic.

Mechanism of Action of Mezlocillin

Mezlocillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Mezlocillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of mezlocillin results from the inhibition of cell wall synthesis and is mediated through mezlocillin binding to penicillin binding proteins (PBPs). Mezlocillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Mezlocillin inhibits bacterial cell wall synthesis.

Pharmacokinets of Mezlocillin

Absorption: It is well absorbed after parenteral administration. Distribution: It is very widely distributed in the body. Metabolism: Only a very small drug undergoes metabolism. Excretion: Mainly excreted in urine. Small amount is excreted through bile and breast milk.

Onset of Action for Mezlocillin

N/A

Duration of Action for Mezlocillin

N/A

Half Life of Mezlocillin

45 - 90 minutes

Side Effects of Mezlocillin

1.Nausea
2.Vomiting
3.Diarrhea
4.Headache
5.Pseudo membranous colitis
6.Edema
7.Fever
8.Rash
9.Pruritus

Contra-indications of Mezlocillin

Hypersensitivity to Mezlocillin

Special Precautions while taking Mezlocillin

1.Uremia
2.Hypokalaemia

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

May be used

Indications for Mezlocillin

1.Lower respiratory tract infections
2.Intra-abdominal infections
3.Uncomplicated gonorrhea
4.Gynecological infection
5.Skin infection
6.Septicemia
7.Urinary tract infection

Interactions for Mezlocillin

N/A

Typical Dosage for Mezlocillin

IV or IM
Adults: 200-300mg/kg/day in 4-6 divided doses for 10-14 days
Urinary tract infection: 100 - 125mg/kg daily in 4 divided doses
Gonorrhea: 1 - 2 g
Children below 12years: 50 - 100mg/kg daily in 4 divided doses

Schedule of Mezlocillin

N/A

Storage Requirements for Mezlocillin

Store at refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for next dose and let it warm to room temperature in a clean, dry place.

Effects of Missed Dosage of Mezlocillin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mezlocillin

Give symptomatic and supportive treatment.

Home Delivery for Mezlocillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mezlocillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mezlocillin and other medicines and health products. Home delivery services for mezlocillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mezlocillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mezlocillin before they complete the sale. You can get this information while placing the order for mezlocillin with the pharmacy.

Mezlocillin is a generic medicine name and there are several brands available for it. Some of the brands for mezlocillin might be better known than mezlocillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mezlocillin in stock, you can ask for one of the branded alternatives for mezlocillin.