- Medicine India
- Generic Medicines
- R
- Pharmacology For Rabeprazole +Zinc carnosine
Rabeprazole +Zinc carnosine Pharmacology
Rabeprazole +Zinc carnosine
About Rabeprazole +Zinc carnosineN/AMechanism of Action of Rabeprazole +Zinc carnosineN/APharmacokinets of Rabeprazole +Zinc carnosineN/AOnset of Action for Rabeprazole +Zinc carnosineN/ADuration of Action for Rabeprazole +Zinc carnosineN/AHalf Life of Rabeprazole +Zinc carnosineN/ASide Effects of Rabeprazole +Zinc carnosineN/AContra-indications of Rabeprazole +Zinc carnosineN/ASpecial Precautions while taking Rabeprazole +Zinc carnosineN/APregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Rabeprazole +Zinc carnosineAntiulcerInteractions for Rabeprazole +Zinc carnosineN/ATypical Dosage for Rabeprazole +Zinc carnosineN/ASchedule of Rabeprazole +Zinc carnosineN/AStorage Requirements for Rabeprazole +Zinc carnosineN/AEffects of Missed Dosage of Rabeprazole +Zinc carnosineN/AEffects of Overdose of Rabeprazole +Zinc carnosineN/ARabeprazole
About RabeprazoleBenzimidazole derivative, Proton Pump Inhibitor, Antiulcer.Mechanism of Action of RabeprazoleRabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.Pharmacokinets of RabeprazoleAbsorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for Rabeprazole1hourDuration of Action for Rabeprazole1 dayHalf Life of Rabeprazole1 - 2 hoursSide Effects of Rabeprazole1. Diarrhoea
2. Nausea
3. Headache
4. Vomiting
5. Abdominal pain
6. Dizziness
7. Flatulence
8. Constipation
9. Dyspepsia
10. Flu like syndrome
11. Insomnia
12. Back pain
13. Cough
14. Rhinitis
15. Pharyngitis
16. Rash
Contra-indications of Rabeprazole1. Hypersensitivity to Rabeprazole sodiumSpecial Precautions while taking Rabeprazole1. Hepatic impairment
2. Monitor gastric malignancy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Rabeprazole1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for RabeprazoleKetoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for RabeprazoleOral
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year
Children: not recommended
Schedule of RabeprazoleHStorage Requirements for RabeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RabeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RabeprazoleGive supportive measures and symptomatic treatment.Zinc carnosine
About Zinc carnosineAntiulcer, antigastritis and mucosal protective,hepatoprotective . Zinc carnosine is an insoluble chelate compound consisting of a zinc ion and L-carnosine.
Mechanism of Action of Zinc carnosineZinc carnosine shows a long-term adhesive and permeable action on the gastric mucosa in acetic acid ulcer, and it has a comparable high affinity at the ulcerous site. Zinc carnosine protects epithelial cell membranes in the stomach and restores them to their normal metabolism.
Zinc carnosine inhibits the growth of the bacteria (H.Pyrlori), probably by strengthening the stomach mucosa and making it less susceptible to a bacterial infection. In experiments, the supplement Zinc carnosine retarded the TNF-alpha secretion of interleukin-8, a ?molecule involved in the inflammatory process.
Pharmacokinets of Zinc carnosineN/AOnset of Action for Zinc carnosineN/ADuration of Action for Zinc carnosineN/AHalf Life of Zinc carnosineN/ASide Effects of Zinc carnosineN/AContra-indications of Zinc carnosineN/ASpecial Precautions while taking Zinc carnosineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc carnosine1.Antiulcer
2.Nutritional supplement
Interactions for Zinc carnosineN/ATypical Dosage for Zinc carnosineRecommended daily dose of 75 mg of zinc carnosine will produce a dietary intake of 17 to l 8 mg of zinc, and 57 to 58 mg of L-carnosine.
Schedule of Zinc carnosineN/AStorage Requirements for Zinc carnosineN/AEffects of Missed Dosage of Zinc carnosineN/AEffects of Overdose of Zinc carnosineN/AHome Delivery for Rabeprazole +Zinc carnosine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rabeprazole +zinc carnosine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rabeprazole +zinc carnosine and other medicines and health products. Home delivery services for rabeprazole +zinc carnosine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take rabeprazole +zinc carnosine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rabeprazole +zinc carnosine before they complete the sale. You can get this information while placing the order for rabeprazole +zinc carnosine with the pharmacy.
Rabeprazole +Zinc carnosine is a generic medicine name and there are several brands available for it. Some of the brands for rabeprazole +zinc carnosine might be better known than rabeprazole +zinc carnosine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rabeprazole +zinc carnosine in stock, you can ask for one of the branded alternatives for rabeprazole +zinc carnosine.
