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- Pharmacology For Cefixime + Ofloxacin
Cefixime + Ofloxacin Pharmacology
Cefixime + OfloxacinAbout Cefixime + OfloxacinN/AMechanism of Action of Cefixime + OfloxacinN/APharmacokinets of Cefixime + OfloxacinN/AOnset of Action for Cefixime + OfloxacinN/ADuration of Action for Cefixime + OfloxacinN/AHalf Life of Cefixime + OfloxacinN/ASide Effects of Cefixime + OfloxacinN/AContra-indications of Cefixime + OfloxacinN/ASpecial Precautions while taking Cefixime + OfloxacinN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cefixime + Ofloxacin1.Tonsillitis
6.Infections caused by susceptible bacterias
Interactions for Cefixime + OfloxacinN/ATypical Dosage for Cefixime + OfloxacinN/ASchedule of Cefixime + OfloxacinN/AStorage Requirements for Cefixime + OfloxacinN/AEffects of Missed Dosage of Cefixime + OfloxacinN/AEffects of Overdose of Cefixime + OfloxacinN/A
CefiximeAbout CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
5. Pseudo membranous colitis
8. Elevated liver enzymes
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
5.Urinary tract infections
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis
OfloxacinAbout OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
4. Abdominal discomfort
6. Dry mouth
11. Pseudomembranous colitis
12. Visual disturbances
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
12. Gynaecological infections
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done.
Home Delivery for Cefixime + Ofloxacin in Your City
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Cefixime + Ofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for cefixime + ofloxacin might be better known than cefixime + ofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefixime + ofloxacin in stock, you can ask for one of the branded alternatives for cefixime + ofloxacin.