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- Pharmacology For Cefixime + Dicloxacillin + Lactobacillus
Cefixime + Dicloxacillin + Lactobacillus Pharmacology
Cefixime + Dicloxacillin + Lactobacillus
About Cefixime + Dicloxacillin + LactobacillusN/AMechanism of Action of Cefixime + Dicloxacillin + LactobacillusN/APharmacokinets of Cefixime + Dicloxacillin + LactobacillusN/AOnset of Action for Cefixime + Dicloxacillin + LactobacillusN/ADuration of Action for Cefixime + Dicloxacillin + LactobacillusN/AHalf Life of Cefixime + Dicloxacillin + LactobacillusN/ASide Effects of Cefixime + Dicloxacillin + Lactobacillus1.Nausea
2.Drowsiness
3.Skin rash
4.Diarrhea.
Contra-indications of Cefixime + Dicloxacillin + LactobacillusN/ASpecial Precautions while taking Cefixime + Dicloxacillin + LactobacillusN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Cefixime + Dicloxacillin + Lactobacillus1.Uncomplicated utis
2.Otitis media
3.Pharyngitis
4.Tonsillitis
5.Acute bronchitis
6.Acute exacerbations of chronic bronchitis
7.Uncomplicated gonorrhea.
8.To treat various types of infections caused by susceptible bacteria
Interactions for Cefixime + Dicloxacillin + LactobacillusN/ATypical Dosage for Cefixime + Dicloxacillin + LactobacillusN/ASchedule of Cefixime + Dicloxacillin + LactobacillusN/AStorage Requirements for Cefixime + Dicloxacillin + LactobacillusN/AEffects of Missed Dosage of Cefixime + Dicloxacillin + LactobacillusN/AEffects of Overdose of Cefixime + Dicloxacillin + LactobacillusN/ACefixime
About CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis Dicloxacillin
About DicloxacillinA semisynthetic narrow spectrum beta-lactam antibiotic ofpenicillin class, Penicillinase resistant Antibiotic.Mechanism of Action of DicloxacillinLike other ?-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.Pharmacokinets of DicloxacillinAbsorption :Absorption after oral administration is rapid but incomplete,food delays absorption
Distribution: widespread, highest in kidneys & liver, CSF low
Protein Binding: 96%
Metabolism: hepatic CYP3A4
Excretion: renal, feces
Onset of Action for DicloxacillinN/ADuration of Action for DicloxacillinN/AHalf Life of Dicloxacillin0.7 hourSide Effects of Dicloxacillin1.Diarrhoea
2.Nausea
3.Rash
4.Urticaria
5.Pain and inflammation at injection site
6.Superinfection (including candidiasis)
7.Allergy
8.Transient increases in liver enzymes and bilirubin
Contra-indications of Dicloxacillin1.Hypersensitivity to penicillins,cephalosporins, carbapenems
2.Not to be used in the eye
3.Cholestatic hepatitis associated with the use of dicloxacillin
Special Precautions while taking Dicloxacillin1.Renal impairment
2.Hepatic impairment
Pregnancy Related InformationUse with caution Old Age Related InformationUse with caution Breast Feeding Related InformationExcreted in breast milk, use cautionChildren Related InformationN/AIndications for Dicloxacillin1.Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
2.Staphylococcal skin infections and cellulitis ? including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
3.Pneumonia (adjunct)
4.Osteomyelitis, septic arthritis, throat infections, streptococcus
5.Septicaemia
6.Empirical treatment for endocarditis
7.Surgical prophylaxis
Interactions for Dicloxacillin1.Dicloxacillin decreases anticoagulant effect of warfarin
2.Probenecid prolongs T1/2 of dicloxacillin
3.Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Typical Dosage for DicloxacillinAdult:250 to 500mg in every 6 hours
Paediatric:<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Schedule of DicloxacillinN/AStorage Requirements for DicloxacillinN/AEffects of Missed Dosage of DicloxacillinN/AEffects of Overdose of DicloxacillinN/ALactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Cefixime + Dicloxacillin + Lactobacillus in Your City
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