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- Pharmacology For Ampicillin + Cloxacillin + Lactobacillus
Ampicillin + Cloxacillin + Lactobacillus Pharmacology
Ampicillin + Cloxacillin + Lactobacillus
About Ampicillin + Cloxacillin + LactobacillusN/AMechanism of Action of Ampicillin + Cloxacillin + LactobacillusN/APharmacokinets of Ampicillin + Cloxacillin + LactobacillusN/AOnset of Action for Ampicillin + Cloxacillin + LactobacillusN/ADuration of Action for Ampicillin + Cloxacillin + LactobacillusN/AHalf Life of Ampicillin + Cloxacillin + LactobacillusN/ASide Effects of Ampicillin + Cloxacillin + LactobacillusN/AContra-indications of Ampicillin + Cloxacillin + LactobacillusN/ASpecial Precautions while taking Ampicillin + Cloxacillin + LactobacillusN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ampicillin + Cloxacillin + LactobacillusN/AInteractions for Ampicillin + Cloxacillin + LactobacillusN/ATypical Dosage for Ampicillin + Cloxacillin + LactobacillusN/ASchedule of Ampicillin + Cloxacillin + LactobacillusN/AStorage Requirements for Ampicillin + Cloxacillin + LactobacillusN/AEffects of Missed Dosage of Ampicillin + Cloxacillin + LactobacillusN/AEffects of Overdose of Ampicillin + Cloxacillin + LactobacillusN/AAmpicillin
About AmpicillinSemisynthetic Broad spectrum beta-lactam antibiotic, Aminobenzylpenicillin AntibioticMechanism of Action of AmpicillinAmpicillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Ampicillin is active against both gram positive and gram negative organism.Pharmacokinets of AmpicillinAbsorption .It is readily but incompletely absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through bile and small amount excreted through urine and breast milk.Onset of Action for Ampicillin30 minutesDuration of Action for Ampicillin6 - 8 hoursHalf Life of Ampicillin90 minutesSide Effects of Ampicillin1.Nausea
2.Vomiting
3.Diarrhoea
4.Anaphylaxis
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure.
Contra-indications of Ampicillin1.Hypersensitivity to PenicillinSpecial Precautions while taking Ampicillin1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Ampicillin1.Urinary tract infections
2.Gonorrhoea
3. Meningitis
4.SABE
5. Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliary tract nfections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Cholecystitis
17.Paratyphoid fever
Interactions for AmpicillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Allopurinol: Increases risk of ampicillin induced skin rash.
Beta blockers: Oral penicillin like ampicillin may reduce bio-availability of atenolol. Also they may potentiate anaphylatic reactions with penicillin.
Probenecid: Increases blood levels.
Erythromycin, Tetracycline: Reduce efficacy.
Clavulinic Acid: Synergy.
Food: Interferes with absorption.Typical Dosage for AmpicillinADULT
Bacterial infections: 250 - 500 mg four times a day depending on the severity of infection
Typhoid and paratyphoid fever: 1 - 2 g four times daily
CHILDREN
Bacterial infections: 125 - 250 mg four times a day depending on the severity of infection
.Schedule of AmpicillinHStorage Requirements for AmpicillinStore the drug at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of AmpicillinTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and continue the regular schedule. Do not double the dose.Effects of Overdose of AmpicillinGive supportive measures and symptomatic treatment. Absorption of the drug can be reduced by administration of activated charcoal.Cloxacillin
About CloxacillinIt is a Penicillinase resistant Penicillin, Penicillin derived antibiotic.Mechanism of Action of CloxacillinCloxacillin is a bactericidal drug. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. In addition to this it is not degraded by penicillinase enzyme and therefore it can be useful against penicillinase producing bacteria also.Pharmacokinets of CloxacillinAbsorption .It is readily absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through urine and small amount excreted through breast milk.Onset of Action for Cloxacillin30-60 minutesDuration of Action for CloxacillinAbout 6 hoursHalf Life of Cloxacillin30 minutesSide Effects of Cloxacillin1.Anaphylaxis
2.Rash
3.Urticaria
4.Thrombocytopenia
5.Seizure
Contra-indications of CloxacillinHypersensitive to Cloxacillin or other Penicillins.Special Precautions while taking Cloxacillin1.Heart failure
2.Uremia
3.Hypokalemia
4 Bleeding tendencies
5.Meningitis
6.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cloxacillin1.Urinary tract infections
2.Respiratory tract infections
3.Septicaemia
4.Osteomyelitis
5.Endocarditis
6.Pneumonia
7.Sinusitis
8.Bronchiectasis
Interactions for CloxacillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Atenolol: Bio-availability of atenolol reduced.
Allopurinol: Increases risk of cloxacillin induced skin rash.
Probenecid: Increases blood levels.
Erythromycin & Tetracyclines: Reduce efficacy.
Clavulanic Acid: Synergy.
Food: Interferes with absorptionTypical Dosage for CloxacillinADULT
1 - 2 g daily in four divided dose depending on the severity of infection
CHILDREN
50 - 100 mg/kg/day in four divided dose depending on the severity of infection
Schedule of CloxacillinHStorage Requirements for CloxacillinThe vial should be stored in room temperature away from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of CloxacillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of CloxacillinGive supportive measures and symptomatic treatment. Absorption of drug can be reduced by gastric lavage or induction of emesisLactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Ampicillin + Cloxacillin + Lactobacillus in Your City
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Ampicillin + Cloxacillin + Lactobacillus is a generic medicine name and there are several brands available for it. Some of the brands for ampicillin + cloxacillin + lactobacillus might be better known than ampicillin + cloxacillin + lactobacillus itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ampicillin + cloxacillin + lactobacillus in stock, you can ask for one of the branded alternatives for ampicillin + cloxacillin + lactobacillus.
