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- Pharmacology For Choline Salicylate + Cetalkonium + Ethanol
Choline Salicylate + Cetalkonium + Ethanol Pharmacology
Choline Salicylate + Cetalkonium + EthanolAbout Choline Salicylate + Cetalkonium + EthanolN/AMechanism of Action of Choline Salicylate + Cetalkonium + EthanolN/APharmacokinets of Choline Salicylate + Cetalkonium + EthanolN/AOnset of Action for Choline Salicylate + Cetalkonium + EthanolN/ADuration of Action for Choline Salicylate + Cetalkonium + EthanolN/AHalf Life of Choline Salicylate + Cetalkonium + EthanolN/ASide Effects of Choline Salicylate + Cetalkonium + EthanolN/AContra-indications of Choline Salicylate + Cetalkonium + EthanolN/ASpecial Precautions while taking Choline Salicylate + Cetalkonium + EthanolN/APregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationNot recommended below 16 yrsIndications for Choline Salicylate + Cetalkonium + EthanolTo relieve the pain of mouth ulcers and denture sores.Interactions for Choline Salicylate + Cetalkonium + EthanolN/ATypical Dosage for Choline Salicylate + Cetalkonium + EthanolN/ASchedule of Choline Salicylate + Cetalkonium + EthanolN/AStorage Requirements for Choline Salicylate + Cetalkonium + EthanolN/AEffects of Missed Dosage of Choline Salicylate + Cetalkonium + EthanolN/AEffects of Overdose of Choline Salicylate + Cetalkonium + EthanolN/A
Choline salicylateAbout Choline salicylateN/AMechanism of Action of Choline salicylateCholine salicylate has analgesic and anti-inflammatory action.
Peripheral action: It acts by inhibition of Prostaglandin (PGs) synthesis by blocking the activity of the precursor enzyme cyclo-oxygenase.
Anti-inflammatory action: It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Choline salicylate inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits other inflammatory mediators.
Pharmacokinets of Choline salicylateN/AOnset of Action for Choline salicylateN/ADuration of Action for Choline salicylateN/AHalf Life of Choline salicylateN/ASide Effects of Choline salicylate1.Salicylism
Contra-indications of Choline salicylate1.Hypersensitivity to Choline salicylate
2. Influenza in childrenSpecial Precautions while taking Choline salicylate1.Renal failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Choline salicylate1.Pain
6.Juvenile rheumatoid arthritis
Interactions for Choline salicylateN/ATypical Dosage for Choline salicylateOral
Adults: 3g / day in single or in 2 divided doses.
Topical preparation: Apply the medicament to the affected area
Children: 1 - 2.25 g/ day in 2 divided doses
Below 3 years: Contraindicated
Schedule of Choline salicylateHStorage Requirements for Choline salicylateStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of Choline salicylateTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose.Effects of Overdose of Choline salicylateGive supportive measures and treatment.
CetalkoniumAbout CetalkoniumCationic quaternary ammonium surfactant, anti-infective and disinfectant.Mechanism of Action of CetalkoniumN/APharmacokinets of CetalkoniumN/AOnset of Action for CetalkoniumN/ADuration of Action for CetalkoniumN/AHalf Life of CetalkoniumN/ASide Effects of CetalkoniumN/AContra-indications of CetalkoniumN/ASpecial Precautions while taking CetalkoniumN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for CetalkoniumTopical anti infective and disinfectant.Interactions for CetalkoniumN/ATypical Dosage for CetalkoniumN/ASchedule of CetalkoniumN/AStorage Requirements for CetalkoniumStored in a well closed container. Keep out of the reach of children.Effects of Missed Dosage of CetalkoniumN/AEffects of Overdose of CetalkoniumN/A
EthanolAbout EthanolAlcohol(a volatile, flammable, colorless liquid), Sedative, Disinfectant,preservative.Mechanism of Action of EthanolAlcohol promotes GABAA receptor mediated synaptic inhibition and inhibits NMDA and kainite type of excitatory amino acid receptors. It also causes augmentation of action of serotonin (5-HT) on 5HT3 inhibitory autoreceptor. It indirectly reduces neurotransmitter release by inhibiting voltage sensitive neuronal calcium channels. It also blocks adenosine uptake which could also contribute to the synaptic depression. It enhances turnover of nor-adrenaline in brain through an opioid receptor dependent mechanism which results in pleasurable effects. It also alters activity of membrane bound enzymes like Na+K+ATPase and adenylyl cyclase.
Alcohol possesses mild rubefacient and counterirritant action on skin. It also acts as an astringent and antiseptic on skin. It precipitates bacterial proteins. It acts as respiratory stimulant in collapse. It irritates buccal and pharyngeal mucosa and causes transient reflex stimulation of respiration. Mild to moderate amount of alcohol has been raises HDL level and reduce LDL oxidation. Blood concentration of Ethanol 100mg/dl saturates alcohol dehydrogenase and retards Methanol metabolism and thus effective in methanol poisoning.
Pharmacokinets of EthanolAbsorption: Rapidly absorbed from intestine, Distribution: Widely distributed in the body, crosses the blood brain barrier and placenta, Metabolism: It is oxidized in liver up to 98%, Excretion: Excreted through kidney and lungs.Onset of Action for EthanolN/ADuration of Action for EthanolN/AHalf Life of EthanolN/ASide Effects of EthanolTopical
After systemic use:
4.Impairment of memory
5.Disorganisation of thought
7.Raise in BP
8.Fall in BP
10.Vasomotor centre depression
19.Cellular necrosis in liver
23.Incresed fatty acid synthesis in liver
Contra-indications of Ethanol(For systemic use):
2.Gastroesophageal reflux disease and hyperacidity
Special Precautions while taking Ethanol1.Do not engage in driving or other hazardous activities requiring mental alertness
2.Safe limits are lower for women
3.Along with other medications
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ethanol1. Antiseptic
2.Rubefacient and counterirritant for sprains, joint pains etc
3.Prevention of bed sores
4.As ingredient of antiperspirant and aftershave lotion
5.As alcoholic sponges to reduce body temperature in fever
7.Ingredient of cough mixtures
8.As Appetite stimulant and carminative
Interactions for EthanolN/ATypical Dosage for EthanolAntiseptic: 70 to 90% Ethanol rubbed on skin surface. Should not apply; on mucous membrane, delicate skin, ulcers etc.
Appetite stimulant and carminative: 30 to 50ml of 7 to 10% ethanol is taken as beverages or tinctures before meals.
Methanol poisoning: Ethanol 10% in water is administered through a nasogastric tube; a loading dose of 0.7ml/kg is followed by 0.15ml/kg/hour drip. Continue the treatment for several days.
Schedule of EthanolN/AStorage Requirements for EthanolStore in a well closed container at a cool and dry place. Protect from heat and light. Keep out of reach of children.Effects of Missed Dosage of EthanolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EthanolTreatment is supportive and symptomatic. Remove alcohol by gastric lavage. Maintain patent airway and takes steps to prevent aspiration of vomitus. If respiratory depression is marked positive pressure respiration is needed. Maintain fluid and electrolyte balance. Correct hypoglycaemia by glucose infusion till alcohol is metabolized. Recovery can be hastened by haemodialysis.
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