Dexketoprofen Pharmacology

Dexketoprofen

About Dexketoprofen
Nonsteroidal anti-inflammatory drugs,analgesic,propionic acid derivative.
Mechanism of Action of Dexketoprofen
Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins.Prostaglandins are produced by the body in response to injury and certain diseases and conditions, and cause pain, swelling and inflammation. Dexketoprofen blocks the production of these prostaglandins and is therefore effective at reducing inflammation and pain.
Pharmacokinets of Dexketoprofen
Absorption: Cmax: About 30 min.
Distribution: Vd: <0.25 L/kg. Highly protein bound.
Excretion: Mainly eliminated via glucuronide conjugation and followed by renal excretion .
Onset of Action for Dexketoprofen
About 30 min.
Duration of Action for Dexketoprofen
About 4-6 hr
Half Life of Dexketoprofen
About 1.65 hr.
Side Effects of Dexketoprofen
1.Indigestion
2.Nausea
3.Vomiting
4.Diarrhea
5.Heartburn
6.Abdominal pain
Contra-indications of Dexketoprofen
1.History of asthma.
2.People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema).
3.People who have been suffering from chronic indigestion.
4.People with an active peptic ulcer or bleeding in the gut.
5.People who have had recurrent peptic ulcers or bleeding from the gut (two or more episodes).
6.People who have ever experienced bleeding or perforation in the gut as a result of taking an NSAID.
7.Inflammatory bowel disease such as Crohn's disease or ulcerative colitis.
8.People with blood clotting disorders or taking anticoagulant medicines.
9.Moderate to severely decreased kidney function.
10.Severely decreased liver function.
11.Severe heart failure.
12It may decrease female fertility. This medicine is not recommended for women who are trying to conceive.

Special Precautions while taking Dexketoprofen
1.History of disorders affecting the stomach or intestines.
2.Decreased kidney function.
3.Decreased liver function.
4.Heart failure.
5.High blood pressure (hypertension).
6.Ischaemic heart disease, eg angina or history of heart attack.
7.Cerebrovascular disease, eg history of stroke or mini-stroke (TIA).
8.Peripheral arterial disease
9.Hyperlipidaemia
10.Diabetes.
11.Smokers.
12.History of allergies
13.Diseases affecting connective tissue, eg systemic lupus erythematosus.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Not recommended under 18 yrs
Indications for Dexketoprofen
Short-term relief of mild to moderate pain in adults, such as:Pain in the muscles, bones or joints,Period pain (dysmenorrhoea),Toothache. etc
Interactions for Dexketoprofen
1.Concomitant use of salicylates, other NSAIDs, anticoagulant (e.g. warfarin, heparin) or corticosteroids may increase risk of bleeding and combination use is not recommended.
2.Caution if used with thrombolytics, anti-platelets, selective serotonin reuptake inhibitors, pentoxyfylline due to elevated bleeding risk.
3.May increase toxic effects of hydantoines and sulphonamides.
4.May reduce effects of antihypertensives.
5.Increased risk of red cell line toxicity with zidovudine, monitor complete blood count and reticulocyte count.
6.Renal function may be worsened when used with ciclosporin or tacrolimus.
7.May increase hypoglycaemic effect of sulfonylureas.
8.Probenacid may increase plasma concentration of Dexketoprofen.
9.Potentially Fatal: NSAIDS may increase blood lithium levels; and increase haematological toxicity of methotrexate.
Typical Dosage for Dexketoprofen
Adult:25 mg every 8 hours, daily dosage should not exceed 75 mg.
In elderly patients, light to moderate liver and renal failure, the maximum dosage is set at a maximum of 50 mg/24h
Schedule of Dexketoprofen
N/A
Storage Requirements for Dexketoprofen
Oral: Store at below 30?C; protect from light.
Effects of Missed Dosage of Dexketoprofen
N/A
Effects of Overdose of Dexketoprofen
Administer activated charcoal if more than 5 mg/kg has been ingested by an adult or a child within an hr. Symptomatic therapy should be provided. Dexketoprofen is dialysable.

Home Delivery for Dexketoprofen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexketoprofen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexketoprofen and other medicines and health products. Home delivery services for dexketoprofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dexketoprofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexketoprofen before they complete the sale. You can get this information while placing the order for dexketoprofen with the pharmacy.

Dexketoprofen is a generic medicine name and there are several brands available for it. Some of the brands for dexketoprofen might be better known than dexketoprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexketoprofen in stock, you can ask for one of the branded alternatives for dexketoprofen.