Dexketoprofen + Paracetamol Pharmacology
Dexketoprofen + Paracetamol
2.Abdominal pain
3.Diarrhea
4.Dyspepsia
5.Headache
6.Dizziness
7.Vertigo
8.Flushing
9.Gastritis
10.Constipation
11.Dry mouth
12.Flatulence
13.Rash
14.Fatigue
15.Thrombocytopenia.
2.Active or suspected gastrointestinal ulcer/haemorrhage or history of gastrointestinal ulcer/ haemorrhage, other active bleedings or bleeding disorders, chronic dyspepsia,
3.Severe hepatic and renal failure
2.Patients with cardiovascular diseases
Dexketoprofen
Distribution: Vd: <0.25 L/kg. Highly protein bound.
Excretion: Mainly eliminated via glucuronide conjugation and followed by renal excretion .
2.Nausea
3.Vomiting
4.Diarrhea
5.Heartburn
6.Abdominal pain
2.People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema).
3.People who have been suffering from chronic indigestion.
4.People with an active peptic ulcer or bleeding in the gut.
5.People who have had recurrent peptic ulcers or bleeding from the gut (two or more episodes).
6.People who have ever experienced bleeding or perforation in the gut as a result of taking an NSAID.
7.Inflammatory bowel disease such as Crohn's disease or ulcerative colitis.
8.People with blood clotting disorders or taking anticoagulant medicines.
9.Moderate to severely decreased kidney function.
10.Severely decreased liver function.
11.Severe heart failure.
12It may decrease female fertility. This medicine is not recommended for women who are trying to conceive.
2.Decreased kidney function.
3.Decreased liver function.
4.Heart failure.
5.High blood pressure (hypertension).
6.Ischaemic heart disease, eg angina or history of heart attack.
7.Cerebrovascular disease, eg history of stroke or mini-stroke (TIA).
8.Peripheral arterial disease
9.Hyperlipidaemia
10.Diabetes.
11.Smokers.
12.History of allergies
13.Diseases affecting connective tissue, eg systemic lupus erythematosus.
2.Caution if used with thrombolytics, anti-platelets, selective serotonin reuptake inhibitors, pentoxyfylline due to elevated bleeding risk.
3.May increase toxic effects of hydantoines and sulphonamides.
4.May reduce effects of antihypertensives.
5.Increased risk of red cell line toxicity with zidovudine, monitor complete blood count and reticulocyte count.
6.Renal function may be worsened when used with ciclosporin or tacrolimus.
7.May increase hypoglycaemic effect of sulfonylureas.
8.Probenacid may increase plasma concentration of Dexketoprofen.
9.Potentially Fatal: NSAIDS may increase blood lithium levels; and increase haematological toxicity of methotrexate.
In elderly patients, light to moderate liver and renal failure, the maximum dosage is set at a maximum of 50 mg/24h
Paracetamol
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
4. Rash
2. Renal impairment
3. Hypertension
NEONATES : Contraindicated
2. Acute gout
3. Migraine
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Dexketoprofen + Paracetamol in Your City
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Dexketoprofen + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for dexketoprofen + paracetamol might be better known than dexketoprofen + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexketoprofen + paracetamol in stock, you can ask for one of the branded alternatives for dexketoprofen + paracetamol.
