Telmisartan + Indapamide Pharmacology

Telmisartan + Indapamide

About Telmisartan + Indapamide
N/A
Mechanism of Action of Telmisartan + Indapamide
N/A
Pharmacokinets of Telmisartan + Indapamide
N/A
Onset of Action for Telmisartan + Indapamide
N/A
Duration of Action for Telmisartan + Indapamide
N/A
Half Life of Telmisartan + Indapamide
N/A
Side Effects of Telmisartan + Indapamide
N/A
Contra-indications of Telmisartan + Indapamide
N/A
Special Precautions while taking Telmisartan + Indapamide
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Telmisartan + Indapamide
Hypertension.
Interactions for Telmisartan + Indapamide
N/A
Typical Dosage for Telmisartan + Indapamide
N/A
Schedule of Telmisartan + Indapamide
N/A
Storage Requirements for Telmisartan + Indapamide
N/A
Effects of Missed Dosage of Telmisartan + Indapamide
N/A
Effects of Overdose of Telmisartan + Indapamide
N/A

Telmisartan

About Telmisartan
Angiotensin II Receptor antagonist, Antihypertensive.
Mechanism of Action of Telmisartan
It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.
Pharmacokinets of Telmisartan
Absorption: Absorbed orally, bioavailability is about 42% Distribution: It is distributed in to the body in a highly protein bound form, Metabolism: Metabolized by glucuronide conjugation in to an inactive metabolite. Excretion: Excreted mainly through faeces and rest is excreted through urine.
Onset of Action for Telmisartan
N/A
Duration of Action for Telmisartan
24 hours
Half Life of Telmisartan
24 hours
Side Effects of Telmisartan
1.Dizziness
2.Headache
3.Coughing
4.Edema
5.Nausea
6.Abdominal pain
7.Diarrhoea
8.Dyspepsia
9.Pharyngitis
10.Sinusitis
11.Upper respiratory tract infections
12.Urinary tract infections
13.Elevated liver enzymes
14.Weakness
15.Chest pain
16.Myalgia
17.Back pain
18.Neutropenia
19.Fetopathic
20.Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
21.Urticaria
22.Rashes
23.Hyperkalemia

Contra-indications of Telmisartan
Hypersensitivity to the drug
Special Precautions while taking Telmisartan
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Use cautiously in volume depleted and salt depleted individuals, these conditions should be corrected before starting the therapy
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy
8.Avoid alcohol or use with caution during therapy
9.Use with caution in hyperkalemia and along with potassium sparing diuretics

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Telmisartan
1.Hypertension
Interactions for Telmisartan
N/A
Typical Dosage for Telmisartan
40mg once daily
Maintenance dose: 20 to 80mg once daily

Schedule of Telmisartan
H
Storage Requirements for Telmisartan
Store at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container. Do not remove blisters until just before taking tablets


Effects of Missed Dosage of Telmisartan
Take the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular dose
Effects of Overdose of Telmisartan
Treatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal saline

Indapamide

About Indapamide
Thiazide-related(a non-thiazide sulphonamide) drug, Diuretic, Antihypertensive.
Mechanism of Action of Indapamide
It exerts thiazides like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion.
It causes vasodilatation by Ca channel blockade. It decreases total peripheral resistance and exerts anti hypertensive action. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.


Pharmacokinets of Indapamide
Absorption: It is compleately absorbed orally.
Distribution: Widely distributed
Metabolism: Extensively metabolized inside the body, and a small portion reaches tubular fluid.
Excretion: Excreted mainly through urine and rest is excreted through faeces.
Onset of Action for Indapamide
1 to 2 hours
Duration of Action for Indapamide
24 to 36 hours
Half Life of Indapamide
N/A
Side Effects of Indapamide
1. Dizziness
2 Headache
3. Orthostatic hypotension
4. Back pain
5. Infection
6. Rhinitis
7. Pharyngitis
8. Sinusitis
9. Vertigo
10 Nausea
11. Diarrhoea
12. Vomiting
13. Constipation
14. Muscle cramps
15. Peripheral edema
16. Polyuria
17. Weakness
18. Hypochloremia
19. Hypokalaemia
20. Hyponatraemia
21. Hyper urecaemia
22. Elevated levels of glucose calcium and lipids
23. Gastro intestinal disturbances
24. Impotence
25. Visual impairment
26. Electrolyte imbalance
27.Ototoxicity
Contra-indications of Indapamide
1. Hepatic impairment.
2. Hypersensitivity to the drug
3. Hypersensitivity to Sulfonamides
4. Anuric renal failure
5. Cerebro vascular accidents

Special Precautions while taking Indapamide
1. Renal impairment
2. Progressive Liver diseases
3. Hyper urecaemia and Gout
4. Diabetes mellitus
5. Fluid and electrolyte imbalance
6. Cirrhosis
7. Hyper calcaemia
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Indapamide
1. Hypertension
2. Oedema
Interactions for Indapamide
Diazoxide: Synergistic action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Frusemide: Synergy leading to profound diuresis and greater than predicted electroyte loss.
Sulfonylureas: Hypoglycaemic effects enhanced.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of indapamide increased.
Metoclopramide: Bioavailability of indapamide decreased.
NSAID`s: Natriuretic effect of indapamide decreased.
Typical Dosage for Indapamide
Hyper tension: 1.25mg single daily dose. Increased to 2.5mg if required after 4 weeks.
Maximum dose: 5mg/day
Edema: 2.5mg single daily dose. Increased to 5mg if required after 1 week.

Schedule of Indapamide
G
Storage Requirements for Indapamide
Store at a cool dry place; and at a temperature below 30 degree C. in a well closed container. Keep out of reach of children.
Effects of Missed Dosage of Indapamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Indapamide
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.

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Telmisartan + Indapamide is a generic medicine name and there are several brands available for it. Some of the brands for telmisartan + indapamide might be better known than telmisartan + indapamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have telmisartan + indapamide in stock, you can ask for one of the branded alternatives for telmisartan + indapamide.