Cefipime Pharmacology


About Cefipime
4th generation cephalosporin.
Mechanism of Action of Cefipime
It inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs).
Pharmacokinets of Cefipime
Absorption: IM admin: Rapid and almost complete absorption.
Distribution: 16-19% bound to plasma proteins. Volume of distribution: 14-20 L; crosses the blood brain barrier. Penetrates into inflammatory fluid at concentrations of about 80% of serum levels.
Metabolism: Minimally hepatic.
Excretion:Excreted in urine with 85% as unchanged drug.
Onset of Action for Cefipime
Duration of Action for Cefipime
Half Life of Cefipime
2 hr
Side Effects of Cefipime
1.Positive Coombs' test without haemolysis
9.Pain and erythema at inj site
11.Anaphylactic shock
Contra-indications of Cefipime
Hypersensitivity to cefepime or other cephalosporins.
Special Precautions while taking Cefipime
1.Renal impairment
2.History of penicillin or cephalosporin allergy
3.Caution when used in patients with history of GI diseases, especially colitis.
4.May decrease prothrombin activity; monitor prothrombin time in patients with poor nutritional state, renal or hepatic impairment and those on prolonged treatment.
5.Prolonged treatment may result in overgrowth of nonsusceptible organisms, resulting in superinfection.
6.Consider the possibility of Clostridium difficile associated diarrhoea in patients who present with diarrhoea after treatment.
7.Caution when used in patients with a history of seizures.
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Cefipime
1.Urinary tract infections
2.Empiric therapy for febrile neutropenic patients
3.Moderate to severe pneumonia
4.Complicated intra-abdominal infections
Interactions for Cefipime
1.Increased effect with high-dose probenecid
2.Increased nephrotoxic potential with aminoglycosides.
Typical Dosage for Cefipime
Adult: IV ;UTI 0.5-1 g 12 hrly for 7-10 days.
Empirical therapy for febrile neutropenia 2 g 8 hrly for 7 days or until resolution of neutropenia.
Moderate to severe pneumonia 1-2 g 12 hrly for 10 days.
Complicated intra-abdominal infections 2 g 12 hrly for 7-10 days.
Uncomplicated skin and skin structure infections 2 g 12 hrly for 10 days.
Schedule of Cefipime
Storage Requirements for Cefipime
Intravenous: In dry state: Store at 2-25?C and protected from light. After reconstitution: Cefepime solution is stable for 24 hr at controlled room temperature (2-25?C) and for 7 days under refridgeration (2-8?C).
Effects of Missed Dosage of Cefipime
Effects of Overdose of Cefipime
Symptoms include encephalopathy, myoclonus, seizures and neuromuscular excitability. Careful observation and supportive treatment are recommended. In the presence of renal insufficiency, haemodialysis may be used to remove cefepime from the body.

Home Delivery for Cefipime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefipime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefipime and other medicines and health products. Home delivery services for cefipime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefipime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefipime before they complete the sale. You can get this information while placing the order for cefipime with the pharmacy.

Cefipime is a generic medicine name and there are several brands available for it. Some of the brands for cefipime might be better known than cefipime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefipime in stock, you can ask for one of the branded alternatives for cefipime.