- Medicine India
- Generic Medicines
- S
- Pharmacology For Sitagliptin + Metformin
Sitagliptin + Metformin Pharmacology
Sitagliptin + Metformin
About Sitagliptin + MetforminN/AMechanism of Action of Sitagliptin + MetforminN/APharmacokinets of Sitagliptin + MetforminN/AOnset of Action for Sitagliptin + MetforminN/ADuration of Action for Sitagliptin + MetforminN/AHalf Life of Sitagliptin + MetforminN/ASide Effects of Sitagliptin + MetforminN/AContra-indications of Sitagliptin + MetforminType 1 diabetes or for the treatment of diabetic ketoacidosis.Special Precautions while taking Sitagliptin + MetforminN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Sitagliptin + MetforminTo improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.Interactions for Sitagliptin + MetforminN/ATypical Dosage for Sitagliptin + MetforminN/ASchedule of Sitagliptin + MetforminN/AStorage Requirements for Sitagliptin + MetforminN/AEffects of Missed Dosage of Sitagliptin + MetforminN/AEffects of Overdose of Sitagliptin + MetforminN/ASITAGLIPTIN
About SITAGLIPTINAntidiabetic agent, Oral hypoglycaemicMechanism of Action of SITAGLIPTINVildagliptin is a dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycaemic control by preventing DPP-4 from inactivating the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus prolonging incretin activity in response to ingestion of nutrients. This increases insulin sensitivity, decreases glucagon secretion and improves ?-cell function.Pharmacokinets of SITAGLIPTINAbsorption: Absorbed after oral administration
Distribution: Protein binding 38 %
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for SITAGLIPTINN/ADuration of Action for SITAGLIPTINN/AHalf Life of SITAGLIPTIN8 to 14 hrsSide Effects of SITAGLIPTIN1.Fever
2.Pancreatits
3.Hypersensitivity reactions
Contra-indications of SITAGLIPTIN1.Hypersensitivity reactions
2.Diabetic ketoacidosis
3.Trauma
4.Severe infections
Special Precautions while taking SITAGLIPTINKidney diseasePregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationContraindicatedIndications for SITAGLIPTINType 2 Diabetes mellitusInteractions for SITAGLIPTINDigoxin: Increase concentration of digoxin
Increased risk of hypoglycaemia when used with other anti-diabetic agents
Typical Dosage for SITAGLIPTIN100 mg orally once dailySchedule of SITAGLIPTINN/AStorage Requirements for SITAGLIPTINStore in a well closed container. Keep out of the reach of children.Effects of Missed Dosage of SITAGLIPTINN/AEffects of Overdose of SITAGLIPTINN/AMetformin
About MetforminBiguanide derivative, Oral anti-diabetic.Mechanism of Action of MetforminIt is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.Pharmacokinets of MetforminAbsorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.Onset of Action for MetforminN/ADuration of Action for Metformin6 to 8 hoursHalf Life of Metformin1.5 to 3hoursSide Effects of Metformin1. Abdominal pain
2. Nausea
3. Vomiting
4. Anorexia
5. Metalic taste
6. Mild diarrhea
7. Tiredness
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
12. Diarrhoea
13. Flatulence
14. Dermatitis
15. Rashes.
Contra-indications of Metformin1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
8. Alcoholics.
Special Precautions while taking Metformin1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for MetforminNon-insulin dependent diabetes mellitus (as adjunct to diet and exercise).Interactions for MetforminN/ATypical Dosage for MetforminAdults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable. Schedule of MetforminGStorage Requirements for MetforminStore at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of MetforminTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of MetforminProvide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.Home Delivery for Sitagliptin + Metformin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sitagliptin + metformin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sitagliptin + metformin and other medicines and health products. Home delivery services for sitagliptin + metformin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take sitagliptin + metformin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sitagliptin + metformin before they complete the sale. You can get this information while placing the order for sitagliptin + metformin with the pharmacy.
Sitagliptin + Metformin is a generic medicine name and there are several brands available for it. Some of the brands for sitagliptin + metformin might be better known than sitagliptin + metformin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sitagliptin + metformin in stock, you can ask for one of the branded alternatives for sitagliptin + metformin.
