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- Pharmacology For Lactulose + Ispaghula Husk
Lactulose + Ispaghula Husk Pharmacology
Lactulose + Ispaghula HuskAbout Lactulose + Ispaghula HuskN/AMechanism of Action of Lactulose + Ispaghula HuskN/APharmacokinets of Lactulose + Ispaghula HuskN/AOnset of Action for Lactulose + Ispaghula HuskN/ADuration of Action for Lactulose + Ispaghula HuskN/AHalf Life of Lactulose + Ispaghula HuskN/ASide Effects of Lactulose + Ispaghula HuskN/AContra-indications of Lactulose + Ispaghula HuskN/ASpecial Precautions while taking Lactulose + Ispaghula HuskN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Lactulose + Ispaghula Husk1.Constipation
Interactions for Lactulose + Ispaghula HuskN/ATypical Dosage for Lactulose + Ispaghula HuskN/ASchedule of Lactulose + Ispaghula HuskN/AStorage Requirements for Lactulose + Ispaghula HuskN/AEffects of Missed Dosage of Lactulose + Ispaghula HuskN/AEffects of Overdose of Lactulose + Ispaghula HuskN/A
LactuloseAbout LactuloseA synthetic Disaccharide, Osmotic Laxative, Ammonium Detoxicant.Mechanism of Action of LactuloseLaxative: Lactulose is a synthetic disaccharide of galactose and fructose that resist intestinal disaccharidase activity. The sugars are joined by a beta glycosidic linkage and are resistant to hydrolysis by human digestive enzymes. Lactulose is fermented by a limited number of colonic bacteria. This can lead to changes in the colonic ecosystem in favor of some bacteria, such as lactobacilli and bifidobacteria, which may confer some health benefits. The products of fermentation include lactic acid and small-chain fatty acids. Degradation to short chain fatty acids also increases the osmotic pressure in the intestinal lumen. It also cause an increase in fecal volume due to intraluminal water retention and stimulate colonic propulsive motility result in increased fecal bulk and stimulation of peristalsis.
Hepatic encephalopathy: Patients with severe hepatic impairment are unable to detoxify ammonia (produced by bacterial metabolism of fecal urea) coming from colon. Lactulose broken down and acidifies the colon and convert ammonia (NH3) to polar ammonium (NH4+) and is excreted in the stool.
Pharmacokinets of LactuloseAbsorption: Lactulose is absorbed minimally
Distribution: It is distributed locally, mainly in the colon
Metabolism: Lactulose undergoes metabolism by colonic bacteria
Excretion: Unabsorbed part is excreted through faeces and absorbed part in the urine.
Onset of Action for Lactulose24 - 48 hoursDuration of Action for LactuloseN/AHalf Life of Lactulose1.7-2 hoursSide Effects of LactuloseN/AContra-indications of Lactulose1. Patient on low galactose dietSpecial Precautions while taking Lactulose1.Diabetes mellitus
2.Patient require electrocautery procedures during protoscopy and colonoscopy
3.Along with other laxatives
4.Long term use
5 Those who develop gastrointestinal symptoms (flatus, bloating, diarrhea) with the use of dietary fiber
6.Those with lactose intolerance
Pregnancy Related InformationUse with cautionOld Age Related InformationMay be used
Breast Feeding Related InformationUse with cautionChildren Related InformationMay be used
Indications for Lactulose1.Constipation
3.After barium examination
4.To restore bowel movement after haemorrhoidectomyInteractions for LactuloseN/ATypical Dosage for LactuloseAdult:
Constipation: Doses of 10 to 20 grams daily and if needed dose can be increased to 40 grams/ day
Hepatic encephalopathy: 60 - 120 grams daily.
Syrup: 7.5 - 15 ml to be taken 3 - 4 times daily (Syrup corresponding to 5 to 10 grams of Lactulose) if needed dose can be increased to 30 to 45 ml 3 - 4 times daily
Schedule of LactuloseN/AStorage Requirements for LactuloseStore at 15 - 30 degree C. Avoid freezingEffects of Missed Dosage of LactuloseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of LactuloseNot reported.
Ispaghula HuskAbout Ispaghula HuskBulk forming agent, LaxativeMechanism of Action of Ispaghula HuskAbsorbs water in the GI tract to form a mucilaginous mass which increases the volume of faeces and hence promotes peristalsisPharmacokinets of Ispaghula HuskAbsorption: Absorbed after oral administration
Metabolism: Metabolised in the colon
Onset of Action for Ispaghula HuskN/ADuration of Action for Ispaghula HuskN/AHalf Life of Ispaghula HuskN/ASide Effects of Ispaghula Husk1.Hypersensitivity reactions
2.Temporary increase of flatulence and abdominal distension
Contra-indications of Ispaghula Husk1.Intestinal obstruction
Special Precautions while taking Ispaghula Husk1.Intestinal or oesophageal obstruction
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ispaghula Husk1.Constipation
3.Mild to moderate hypercholesterolaemia
Interactions for Ispaghula HuskMay delay or reduce GI absorption of the cardiac glycosides, coumarin derivatives, lithium, vitamin (e.g. vitamin B12) and minerals (e.g. calcium, iron or zinc), carbamazepineTypical Dosage for Ispaghula HuskConstipation: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Haemorrhoids: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Mild to moderate hypercholesterolaemia: As an adjunct to lipid-lowering diet: 7 g daily
Schedule of Ispaghula HuskN/AStorage Requirements for Ispaghula HuskStore below 40 degree celcius in a well closed container. Protect from sunlight and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Ispaghula HuskN/AEffects of Overdose of Ispaghula HuskN/A
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