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- Pharmacology For Lafutidine + Domperidone
Lafutidine + Domperidone Pharmacology
Lafutidine + Domperidone
About Lafutidine + DomperidoneN/AMechanism of Action of Lafutidine + DomperidoneN/APharmacokinets of Lafutidine + DomperidoneN/AOnset of Action for Lafutidine + DomperidoneN/ADuration of Action for Lafutidine + DomperidoneN/AHalf Life of Lafutidine + DomperidoneN/ASide Effects of Lafutidine + DomperidoneN/AContra-indications of Lafutidine + DomperidoneN/ASpecial Precautions while taking Lafutidine + DomperidoneN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Lafutidine + Domperidone1.Gastric and duodenal ulcers
2.Stomal ulcers
3.Gastric mucosal lesions
Interactions for Lafutidine + DomperidoneN/ATypical Dosage for Lafutidine + DomperidoneN/ASchedule of Lafutidine + DomperidoneN/AStorage Requirements for Lafutidine + DomperidoneN/AEffects of Missed Dosage of Lafutidine + DomperidoneN/AEffects of Overdose of Lafutidine + DomperidoneN/ALafutidine
About LafutidineH2 receptor antagonist,AntiulcerMechanism of Action of LafutidineLafutidine is a H2(Histamine) receptor antagonist.Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP.This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane.Lafutidine reversibly competes with Histamine for binding to H2 receptor on the basolateral membrane of parietal cells and predominantly inhibits basal acid secretion.Pharmacokinets of LafutidineAbsorption: Absorbed after oral administration
Distribution: Bound to protein(88%)
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for LafutidineRapidDuration of Action for Lafutidine4 to 6 hrsHalf Life of LafutidineN/ASide Effects of Lafutidine1.Constipation
2.Hyperuricaemia
3.Increase in LFT and total bilirubin
4.Gynaecomastia
5.Anorexia hallucinations
6.Anaphylactic reactions
Contra-indications of LafutidineHypersensitivity to drugSpecial Precautions while taking Lafutidine1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for LafutidineN/AInteractions for LafutidineN/ATypical Dosage for LafutidineGastric and duodenal ulcers:
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Stomal ulcers:
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Gastric mucosal lesions:
Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Pre-anaesthetic medication:
Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation
Schedule of LafutidineHStorage Requirements for LafutidineStore at room temperature in a closed container.Protect from light. Keep out of the reach of children.Effects of Missed Dosage of LafutidineN/AEffects of Overdose of LafutidineN/ADomperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Home Delivery for Lafutidine + Domperidone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lafutidine + domperidone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lafutidine + domperidone and other medicines and health products. Home delivery services for lafutidine + domperidone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take lafutidine + domperidone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lafutidine + domperidone before they complete the sale. You can get this information while placing the order for lafutidine + domperidone with the pharmacy.
Lafutidine + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for lafutidine + domperidone might be better known than lafutidine + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lafutidine + domperidone in stock, you can ask for one of the branded alternatives for lafutidine + domperidone.
