Latanoprost + Timolol Pharmacology

Latanoprost + Timolol

About Latanoprost + Timolol
N/A
Mechanism of Action of Latanoprost + Timolol
N/A
Pharmacokinets of Latanoprost + Timolol
N/A
Onset of Action for Latanoprost + Timolol
N/A
Duration of Action for Latanoprost + Timolol
N/A
Half Life of Latanoprost + Timolol
N/A
Side Effects of Latanoprost + Timolol
1.Increased iris pigmentation
2.Eye irritation
3.Eye pain
4.Stinging and burning sensation
5.Rarely, bradycardia, arrhythmia, CHF, bronchospasm and allergic reactions

Contra-indications of Latanoprost + Timolol
1.Bronchial asthma or a history of bronchial asthma
2.Severe copd.
3.Sinus bradycardia
4.2nd or 3rd degree av block
5.Overt cardiac failure
6.Cardiogenic shock
Special Precautions while taking Latanoprost + Timolol
1.Monitor heart rate and signs of cardiac failure in patients with history of severe cardiac disease.
2.May worsen Prinzmetal angina, severe peripheral and central circulatory disorders and hypotension.
3.Monitor for signs of bronchospasm in asthmatic patients.
4.?-blockers may mask signs and symptoms of acute hypoglycaemia and hyperthyroidism.
5.Prolonged treatment with latanoprost may change eye colour by increasing the amount of brown pigment in the iris especially in patients with mixed coloured irides; regular eye examination is recommended.
6.Caution when used in aphakic patients due to risk of macular oedema.
7.Contact lenses should be removed during application and reinserted at least 15 minutes after application.
8.May cause transient blurring of vision; patients should not drive or operate machinery until this resolves.
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Latanoprost + Timolol
1.Ocular hypertension
2.Open-angle glaucoma
Interactions for Latanoprost + Timolol
1.Additive effect on the intraocular pressure and other systemic effects may occur when used with oral ?-blockers, calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides or parasympathomimetics.
2.Concurrent use of ?2 ophthalmic prostaglandin analogues may lead to paradoxical increase in intraocular pressure.
3.Mydriasis may occur when used concurrently with epinephrine.
4.?-blocker may increase hypoglycaemic effect of antidiabetic agents.
Typical Dosage for Latanoprost + Timolol
Adult: As eye preparation containing latanoprost 0.005% and timolol 0.5%: Instill 1 drop into the affected eye(s) once daily. Not to be used as an initial therapy.

Schedule of Latanoprost + Timolol
N/A
Storage Requirements for Latanoprost + Timolol
N/A
Effects of Missed Dosage of Latanoprost + Timolol
N/A
Effects of Overdose of Latanoprost + Timolol
Symptoms of systemic timolol overdose: Bradycardia, hypotension, bronchospasm and cardiac arrest. Treatment is symptomatic and supportive. Latanoprost overload can cause ocular irritation and conjunctival hyperaemia, no other ocular or systemic side effects are known. If latanoprost is accidentally ingested orally, gastric lavage may be used. Treatment is symptomatic and supportive.

Latanoprost

About Latanoprost
A prostaglandin analogue, Antiglaucoma.
Mechanism of Action of Latanoprost
Latanoprost is a prostaglandin F2-alpha analogue and it is a prostanoid selective FP receptor agonist which reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor mainly through increasing uveoscleral outflow.
Chemically Latanoprost is an isopropyl ester prodrug and after hydrolyses it forms active acid form.
Pharmacokinets of Latanoprost
Absorption: Latanoprost is absorbed through cornea after ocular administration
Onset of Action for Latanoprost
2 - 4 hour
Duration of Action for Latanoprost
N/A
Half Life of Latanoprost
N/A
Side Effects of Latanoprost
1.Irritation
2.Burning
3.Blurred vision
4.Increased sensitivity of the eyes to light
5.Dry eyes
6.Increased flow of tears
7.Changes in eye, eyelash, or eyelid color
8.Redness of eyes
9.Asthma
10.Eye pain
11.Punctate epithelial keratopathy
Contra-indications of Latanoprost
1.Hypersensitivity to Latanoprost
Special Precautions while taking Latanoprost
1.Avoid use of medicament if any irritation occurs
2.Iritis
3.Uveitis
4.Macular edema
5.Aphakia
6.Closed angle glaucoma
7.Avoid contact lens
8.Renal impairment
9.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated

Indications for Latanoprost
1.Open angle glaucoma
Interactions for Latanoprost
N/A
Typical Dosage for Latanoprost
Latanoprost 0.005 % eye drop is used.
Instill 1 drop in the evening to the affected eye.
Schedule of Latanoprost
N/A
Storage Requirements for Latanoprost
Store in a cool dry place in a tightly closed container. Protect fro heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Latanoprost
Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Latanoprost
A topical ocular overdose of an ophthalmic product containing Latanoprost may be flushed from the eye with warm tap water.

Timolol

About Timolol
Nonselective Beta Adrenergic,Blocker,Ophthalmic- Antiglaucoma,antimigraine.
Mechanism of Action of Timolol
Timolol is a non selective beta blocker. It inhibits the beta receptors (?2) present in the eye such as in the ciliary body epithelium and blood vessels. This will leads to decreased aqueous production and reduced intraocular pressure. Aqueous humor production is activated by ? receptor mediated cyclic AMP phosphokinase pathway. Beta receptor blockers will decreases the intracellular cyclic AMP level and reduces intraocular pressure. Another mechanism is that Timolol decreases the ocular blood flow which decreases ultrafiltration responsible for aqueous production.
Pharmacokinets of Timolol
Absorption: Absorption after ophthalmic use is minimal.
Onset of Action for Timolol
30 minutes
Duration of Action for Timolol
12- 24 hours
Half Life of Timolol
N/A
Side Effects of Timolol
1. Irritation
2. Burning
3. Bronchospasm
4. Blurred vision
5. Increased sensitivity of the eyes to light
6. Redness of eyes
7. Discoloration of the eyeball
8. Eye pain
Contra-indications of Timolol
1. Hypersensitivity to Timolol
2. Bronchial asthma
3. Chronic obstructive pulmonary diseases
4. Sinus Bradycardia
5. Heart failure
6. Cardiogenic shock
7. AV block (2nd or 3rd degree)
Special Precautions while taking Timolol
1. Chronic bronchitis
2. Emphysema
3. Diabetes mellitus
4. Hyperthyroidism
5. Myasthenia gravis
6. Closed angle glaucoma
7. Gradually withdraw the drug in patient with Thyrotoxicosis
8. Cerebrovascular insufficiency
9. Avid use of soft contact lenses.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Timolol
1. Open angle glaucoma
2. Ocular hypertension
Interactions for Timolol
N/A
Typical Dosage for Timolol
Timolol 0.25, and 0.5% eye drops are used.
Instill 1 drop in to the affected eye for 1 - 2 times daily.
Schedule of Timolol
H
Storage Requirements for Timolol
Store in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Timolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Timolol
A topical ocular overdose of an ophthalmic product containing Timolol may be flushed from the eye with warm tap water.

Home Delivery for Latanoprost + Timolol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for latanoprost + timolol and other medicines and health products. Home delivery services for latanoprost + timolol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take latanoprost + timolol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for latanoprost + timolol before they complete the sale. You can get this information while placing the order for latanoprost + timolol with the pharmacy.

Latanoprost + Timolol is a generic medicine name and there are several brands available for it. Some of the brands for latanoprost + timolol might be better known than latanoprost + timolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have latanoprost + timolol in stock, you can ask for one of the branded alternatives for latanoprost + timolol.