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- Pharmacology For Dexibuprofen + Paracetamol
Dexibuprofen + Paracetamol Pharmacology
Dexibuprofen + Paracetamol
About Dexibuprofen + ParacetamolN/AMechanism of Action of Dexibuprofen + ParacetamolN/APharmacokinets of Dexibuprofen + ParacetamolN/AOnset of Action for Dexibuprofen + ParacetamolN/ADuration of Action for Dexibuprofen + ParacetamolN/AHalf Life of Dexibuprofen + ParacetamolN/ASide Effects of Dexibuprofen + Paracetamol1.Dyspepsia
2.Heartburn
3.Anorexia
4.Abdominal pain
5.Distension
Contra-indications of Dexibuprofen + ParacetamolN/ASpecial Precautions while taking Dexibuprofen + ParacetamolN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dexibuprofen + Paracetamol1.Pain and inflammation associated with musculoskeletal and joint disorders
2.Dysmenorrhoea
Interactions for Dexibuprofen + Paracetamol1.Increased risk of bleeding when NSAIDs given with SSRIs.
2.Avoid concomitant use of NSAIDs with aspirin (increased side- effects), ciclosporin, coumarins, erlotinib, ketorolac, lithium & methotrexate.
3.NSAIDs possibly enhance effect pf phenindione, phenytoin, quinolones, sulphonylureas & venlafaxibe.
Typical Dosage for Dexibuprofen + ParacetamolN/ASchedule of Dexibuprofen + ParacetamolN/AStorage Requirements for Dexibuprofen + ParacetamolN/AEffects of Missed Dosage of Dexibuprofen + ParacetamolN/AEffects of Overdose of Dexibuprofen + ParacetamolN/ADexibuprofen
About DexibuprofenN/AMechanism of Action of DexibuprofenN/APharmacokinets of DexibuprofenN/AOnset of Action for DexibuprofenN/ADuration of Action for DexibuprofenN/AHalf Life of DexibuprofenN/ASide Effects of DexibuprofenN/AContra-indications of DexibuprofenN/ASpecial Precautions while taking DexibuprofenN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for DexibuprofenN/AInteractions for DexibuprofenN/ATypical Dosage for DexibuprofenN/ASchedule of DexibuprofenN/AStorage Requirements for DexibuprofenN/AEffects of Missed Dosage of DexibuprofenN/AEffects of Overdose of DexibuprofenN/AParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Dexibuprofen + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexibuprofen + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexibuprofen + paracetamol and other medicines and health products. Home delivery services for dexibuprofen + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dexibuprofen + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexibuprofen + paracetamol before they complete the sale. You can get this information while placing the order for dexibuprofen + paracetamol with the pharmacy.
Dexibuprofen + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for dexibuprofen + paracetamol might be better known than dexibuprofen + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexibuprofen + paracetamol in stock, you can ask for one of the branded alternatives for dexibuprofen + paracetamol.
