Metformin + Benfotiamine Pharmacology

Metformin + Benfotiamine

About Metformin + Benfotiamine
N/A
Mechanism of Action of Metformin + Benfotiamine
N/A
Pharmacokinets of Metformin + Benfotiamine
N/A
Onset of Action for Metformin + Benfotiamine
N/A
Duration of Action for Metformin + Benfotiamine
N/A
Half Life of Metformin + Benfotiamine
N/A
Side Effects of Metformin + Benfotiamine
N/A
Contra-indications of Metformin + Benfotiamine
N/A
Special Precautions while taking Metformin + Benfotiamine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Metformin + Benfotiamine
Nopn insulin dependent diabetes mellitus with diabetic retinopathy nephropathy neuropathy.
Interactions for Metformin + Benfotiamine
N/A
Typical Dosage for Metformin + Benfotiamine
N/A
Schedule of Metformin + Benfotiamine
N/A
Storage Requirements for Metformin + Benfotiamine
N/A
Effects of Missed Dosage of Metformin + Benfotiamine
N/A
Effects of Overdose of Metformin + Benfotiamine
N/A

Metformin

About Metformin
Biguanide derivative, Oral anti-diabetic.
Mechanism of Action of Metformin
It is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.
Pharmacokinets of Metformin
Absorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.
Onset of Action for Metformin
N/A
Duration of Action for Metformin
6 to 8 hours
Half Life of Metformin
1.5 to 3hours
Side Effects of Metformin
1. Abdominal pain
2. Nausea
3. Vomiting
4. Anorexia
5. Metalic taste
6. Mild diarrhea
7. Tiredness
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
12. Diarrhoea
13. Flatulence
14. Dermatitis
15. Rashes.
Contra-indications of Metformin
1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
8. Alcoholics.
Special Precautions while taking Metformin
1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Metformin
Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise).
Interactions for Metformin
N/A
Typical Dosage for Metformin
Adults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable.
Schedule of Metformin
G
Storage Requirements for Metformin
Store at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of Metformin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Metformin
Provide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.

Benfotiamine

About Benfotiamine
Synthetic S-acyl derivative of thiamine (vitamine B1), Antioxidant ,anti-AGE(Advanced glycation end product) supplement, Treating Diabetic Complications.
Mechanism of Action of Benfotiamine
N/A
Pharmacokinets of Benfotiamine
N/A
Onset of Action for Benfotiamine
N/A
Duration of Action for Benfotiamine
N/A
Half Life of Benfotiamine
N/A
Side Effects of Benfotiamine
N/A
Contra-indications of Benfotiamine
N/A
Special Precautions while taking Benfotiamine
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Benfotiamine
1.Management of diabetic neuropathy, diabetic nephropathy and diabetic retinopathy
2.Beri Beri
3.Wenicke-korsakoff syndrome
Interactions for Benfotiamine
N/A
Typical Dosage for Benfotiamine
N/A
Schedule of Benfotiamine
N/A
Storage Requirements for Benfotiamine
N/A
Effects of Missed Dosage of Benfotiamine
N/A
Effects of Overdose of Benfotiamine
N/A

Home Delivery for Metformin + Benfotiamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including metformin + benfotiamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for metformin + benfotiamine and other medicines and health products. Home delivery services for metformin + benfotiamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take metformin + benfotiamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for metformin + benfotiamine before they complete the sale. You can get this information while placing the order for metformin + benfotiamine with the pharmacy.

Metformin + Benfotiamine is a generic medicine name and there are several brands available for it. Some of the brands for metformin + benfotiamine might be better known than metformin + benfotiamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have metformin + benfotiamine in stock, you can ask for one of the branded alternatives for metformin + benfotiamine.