Amlexanox Pharmacology


About Amlexanox
Anti-Allergic Agents,Antiulcer agent (topical),Anti-inflammatory Agents(topical).
Mechanism of Action of Amlexanox
As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1.
Pharmacokinets of Amlexanox
Absorption: Systemic absorption occurs mostly via GI tract; absorption directly through the active ulcer is not significant.
Metabolism: Metabolised to hydroxylated and conjugated metabolites.
Excretion: Excreted in urine.
Onset of Action for Amlexanox
Duration of Action for Amlexanox
Half Life of Amlexanox
About 3.5 hr.
Side Effects of Amlexanox
1.Application site reactions e.g. transient pain, stinging, burning, irritation, contact mucositis
Contra-indications of Amlexanox
Special Precautions while taking Amlexanox
1.For topical use on mouth ulcers only.
2.Avoid contact with the eyes; rinse immediately if ocular contact occurs.
3.Wash hands before and after every application.
4.Discontinue treatment if rash or contact mucositis develops.
5.Seek medical advice if mouth ulcers have not healed after 10 days of treatment.
6.Effects have not been evaluated in immune-compromised patients.
7.Avoid excess dosage
Pregnancy Related Information
Use with caution
Old Age Related Information
Use lower initial dose for elderly patients
Breast Feeding Related Information
Use with caution
Children Related Information
Not to be used in children below age 12
Indications for Amlexanox
Used as a paste in the mouth to treat aphthous ulcers(canker sores).
Interactions for Amlexanox
Typical Dosage for Amlexanox
Schedule of Amlexanox
Storage Requirements for Amlexanox
Topical/Cutaneous: Store at room temperature 15-30?C (59-86?F).
Effects of Missed Dosage of Amlexanox
Effects of Overdose of Amlexanox

Home Delivery for Amlexanox in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amlexanox.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amlexanox and other medicines and health products. Home delivery services for amlexanox may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take amlexanox only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amlexanox before they complete the sale. You can get this information while placing the order for amlexanox with the pharmacy.

Amlexanox is a generic medicine name and there are several brands available for it. Some of the brands for amlexanox might be better known than amlexanox itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amlexanox in stock, you can ask for one of the branded alternatives for amlexanox.