- Medicine India
- Generic Medicines
- A
- Pharmacology For Atorvastatin + Fenofibrate + Folic Acid
Atorvastatin + Fenofibrate + Folic Acid Pharmacology
Atorvastatin + Fenofibrate + Folic Acid
About Atorvastatin + Fenofibrate + Folic AcidN/AMechanism of Action of Atorvastatin + Fenofibrate + Folic AcidN/APharmacokinets of Atorvastatin + Fenofibrate + Folic AcidN/AOnset of Action for Atorvastatin + Fenofibrate + Folic AcidN/ADuration of Action for Atorvastatin + Fenofibrate + Folic AcidN/AHalf Life of Atorvastatin + Fenofibrate + Folic AcidN/ASide Effects of Atorvastatin + Fenofibrate + Folic AcidN/AContra-indications of Atorvastatin + Fenofibrate + Folic AcidN/ASpecial Precautions while taking Atorvastatin + Fenofibrate + Folic AcidN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Atorvastatin + Fenofibrate + Folic Acid1.Mixed dyslipidaemia
2.Hypercholesterolemia
Interactions for Atorvastatin + Fenofibrate + Folic AcidN/ATypical Dosage for Atorvastatin + Fenofibrate + Folic AcidN/ASchedule of Atorvastatin + Fenofibrate + Folic AcidN/AStorage Requirements for Atorvastatin + Fenofibrate + Folic AcidN/AEffects of Missed Dosage of Atorvastatin + Fenofibrate + Folic AcidN/AEffects of Overdose of Atorvastatin + Fenofibrate + Folic AcidN/AAtorvastatin
About AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.Fenofibrate
About FenofibrateFibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.Mechanism of Action of FenofibrateIt is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.Pharmacokinets of FenofibrateAbsorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for FenofibrateN/ADuration of Action for FenofibrateN/AHalf Life of Fenofibrate20 hoursSide Effects of Fenofibrate1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia
Contra-indications of Fenofibrate1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
Special Precautions while taking Fenofibrate1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Fenofibrate1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.Interactions for FenofibrateN/ATypical Dosage for FenofibrateOral: 200mg once daily with food. Adjust the dosage based on patient`s response.Schedule of FenofibrateHStorage Requirements for FenofibrateStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.Effects of Missed Dosage of FenofibrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FenofibrateDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Home Delivery for Atorvastatin + Fenofibrate + Folic Acid in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including atorvastatin + fenofibrate + folic acid.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for atorvastatin + fenofibrate + folic acid and other medicines and health products. Home delivery services for atorvastatin + fenofibrate + folic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take atorvastatin + fenofibrate + folic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for atorvastatin + fenofibrate + folic acid before they complete the sale. You can get this information while placing the order for atorvastatin + fenofibrate + folic acid with the pharmacy.
Atorvastatin + Fenofibrate + Folic Acid is a generic medicine name and there are several brands available for it. Some of the brands for atorvastatin + fenofibrate + folic acid might be better known than atorvastatin + fenofibrate + folic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have atorvastatin + fenofibrate + folic acid in stock, you can ask for one of the branded alternatives for atorvastatin + fenofibrate + folic acid.
