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- Pharmacology For Loratadine + Ambroxol
Loratadine + Ambroxol Pharmacology
Loratadine + AmbroxolAbout Loratadine + AmbroxolN/AMechanism of Action of Loratadine + AmbroxolN/APharmacokinets of Loratadine + AmbroxolN/AOnset of Action for Loratadine + AmbroxolN/ADuration of Action for Loratadine + AmbroxolN/AHalf Life of Loratadine + AmbroxolN/ASide Effects of Loratadine + AmbroxolN/AContra-indications of Loratadine + AmbroxolN/ASpecial Precautions while taking Loratadine + AmbroxolN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Loratadine + AmbroxolCough and coldInteractions for Loratadine + AmbroxolN/ATypical Dosage for Loratadine + AmbroxolN/ASchedule of Loratadine + AmbroxolN/AStorage Requirements for Loratadine + AmbroxolN/AEffects of Missed Dosage of Loratadine + AmbroxolN/AEffects of Overdose of Loratadine + AmbroxolN/A
LoratadineAbout LoratadineSecond Generation H1 Antagonist, Antihistamine.Mechanism of Action of LoratadineLoratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation (activation releasing other chemicals which produce the symptoms associated with allergy) of cells by histamine. Drug also has mast cell stabilizing property.Pharmacokinets of LoratadineAbsorption- Rapidly absorbed after oral administration.
Distribution-Widely distributed in the body.97% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites, Descarboethoxyloratidine is its active metabolite.
Excretion- Excreted through both the urine and feces.
Onset of Action for Loratadine1 - 3 hrsDuration of Action for Loratadine24 hrsHalf Life of LoratadineN/ASide Effects of Loratadine1. Headache
2. Dry mouth, nose, and throat
4. Rapid heartbeat
5. Difficulty urinating
6. Vision problems
8. Muscle weakness
10. Change in menstruation
13. Feeling faint
14. Flushing of the face
20. Shortness of breath
21. Sleeping disorders
22. Sore throat
23. Tightness in the chest or back
24. Yellowing of the eyes or skin
Contra-indications of Loratadine1. Allergy to drug or any other antihistamines
2. Stenosing peptic ulcer
3. Symptomatic prostatic hypertrophy
4. Asthmatic attack
5. Bladder neck obstruction
6. Pyloroduodenal obstruction
7. Narrow-angle glaucoma
Special Precautions while taking LoratadineUse with caution in patients with severe hepatic damage.Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNEONATES- ContraindicatedIndications for Loratadine1. Allergic rhinitis (perennial and seasonal )
2. Vasomotor rhinitis
3. Allergic conjunctivitis
4. Urticaria( mild, uncomplicated )
6. Amelioration of allergic reactions to blood or plasma
8. Adjunctive therapy in anaphylactic reactions
Interactions for LoratadineMacrolide antibiotics, ketoconazole, cimetidine, ranitidine and theophylline: Caution should be exerted while co-administration of these drugs which are known to inhibit hepatic metabolism.Typical Dosage for LoratadineOral-
Children (>6) - Same as adult.
Schedule of LoratadineN/AStorage Requirements for LoratadineStore it at room temperature and away from excess heat and moisture.Effects of Missed Dosage of LoratadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of LoratadineGive symptomatic and supportive treatment. Induce emesis except in patients with impaired consciousness. Then administer activated charcoal to adsorb any remaining drug. Provide gastric lavage if emesis is contraindicated.
AmbroxolAbout AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
3.Gastric and duodenal ulcer
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.
Home Delivery for Loratadine + Ambroxol in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for loratadine + ambroxol and other medicines and health products. Home delivery services for loratadine + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take loratadine + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for loratadine + ambroxol before they complete the sale. You can get this information while placing the order for loratadine + ambroxol with the pharmacy.
Loratadine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for loratadine + ambroxol might be better known than loratadine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loratadine + ambroxol in stock, you can ask for one of the branded alternatives for loratadine + ambroxol.