Loratadine + Ambroxol + Guaiphenesin Pharmacology

Loratadine + Ambroxol + Guaiphenesin

About Loratadine + Ambroxol + Guaiphenesin
N/A
Mechanism of Action of Loratadine + Ambroxol + Guaiphenesin
N/A
Pharmacokinets of Loratadine + Ambroxol + Guaiphenesin
N/A
Onset of Action for Loratadine + Ambroxol + Guaiphenesin
N/A
Duration of Action for Loratadine + Ambroxol + Guaiphenesin
N/A
Half Life of Loratadine + Ambroxol + Guaiphenesin
N/A
Side Effects of Loratadine + Ambroxol + Guaiphenesin
N/A
Contra-indications of Loratadine + Ambroxol + Guaiphenesin
N/A
Special Precautions while taking Loratadine + Ambroxol + Guaiphenesin
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Loratadine + Ambroxol + Guaiphenesin
Cough and cold
Interactions for Loratadine + Ambroxol + Guaiphenesin
N/A
Typical Dosage for Loratadine + Ambroxol + Guaiphenesin
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Schedule of Loratadine + Ambroxol + Guaiphenesin
N/A
Storage Requirements for Loratadine + Ambroxol + Guaiphenesin
N/A
Effects of Missed Dosage of Loratadine + Ambroxol + Guaiphenesin
N/A
Effects of Overdose of Loratadine + Ambroxol + Guaiphenesin
N/A

Loratadine

About Loratadine
Second Generation H1 Antagonist, Antihistamine.
Mechanism of Action of Loratadine
Loratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation (activation releasing other chemicals which produce the symptoms associated with allergy) of cells by histamine. Drug also has mast cell stabilizing property.
Pharmacokinets of Loratadine
Absorption- Rapidly absorbed after oral administration.
Distribution-Widely distributed in the body.97% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites, Descarboethoxyloratidine is its active metabolite.
Excretion- Excreted through both the urine and feces.
Onset of Action for Loratadine
1 - 3 hrs
Duration of Action for Loratadine
24 hrs
Half Life of Loratadine
N/A
Side Effects of Loratadine
1. Headache
2. Dry mouth, nose, and throat
3. Drowsiness
4. Rapid heartbeat
5. Difficulty urinating
6. Vision problems
7. Dizziness
8. Muscle weakness
9. Anxiety
10. Change in menstruation
11. Clumsiness
12. Depression
13. Feeling faint
14. Flushing of the face
15. Hallucinations
16. Migraines
17. Palpitations
18. Rash
19. Seizures
20. Shortness of breath
21. Sleeping disorders
22. Sore throat
23. Tightness in the chest or back
24. Yellowing of the eyes or skin
Contra-indications of Loratadine
1. Allergy to drug or any other antihistamines
2. Stenosing peptic ulcer
3. Symptomatic prostatic hypertrophy
4. Asthmatic attack
5. Bladder neck obstruction
6. Pyloroduodenal obstruction
7. Narrow-angle glaucoma
Special Precautions while taking Loratadine
Use with caution in patients with severe hepatic damage.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
NEONATES- Contraindicated
Indications for Loratadine
1. Allergic rhinitis (perennial and seasonal )
2. Vasomotor rhinitis
3. Allergic conjunctivitis
4. Urticaria( mild, uncomplicated )
5. Angioedema
6. Amelioration of allergic reactions to blood or plasma
7. Dermatographism
8. Adjunctive therapy in anaphylactic reactions
9. Decongestant

Interactions for Loratadine
Macrolide antibiotics, ketoconazole, cimetidine, ranitidine and theophylline: Caution should be exerted while co-administration of these drugs which are known to inhibit hepatic metabolism.
Typical Dosage for Loratadine
Oral-
General dose-
Adult-
10mg/day.
Children (>6) - Same as adult.

Schedule of Loratadine
N/A
Storage Requirements for Loratadine
Store it at room temperature and away from excess heat and moisture.
Effects of Missed Dosage of Loratadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Loratadine
Give symptomatic and supportive treatment. Induce emesis except in patients with impaired consciousness. Then administer activated charcoal to adsorb any remaining drug. Provide gastric lavage if emesis is contraindicated.

Ambroxol

About Ambroxol
Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.
Mechanism of Action of Ambroxol
Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.
Pharmacokinets of Ambroxol
N/A
Onset of Action for Ambroxol
N/A
Duration of Action for Ambroxol
N/A
Half Life of Ambroxol
N/A
Side Effects of Ambroxol
1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.
Contra-indications of Ambroxol
Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.
Special Precautions while taking Ambroxol
1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ambroxol
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.
Interactions for Ambroxol
N/A
Typical Dosage for Ambroxol
Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of Ambroxol
H
Storage Requirements for Ambroxol
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Ambroxol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ambroxol
Provide symptomatic treatment and supportive measures.

Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

Home Delivery for Loratadine + Ambroxol + Guaiphenesin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for loratadine + ambroxol + guaiphenesin and other medicines and health products. Home delivery services for loratadine + ambroxol + guaiphenesin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take loratadine + ambroxol + guaiphenesin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for loratadine + ambroxol + guaiphenesin before they complete the sale. You can get this information while placing the order for loratadine + ambroxol + guaiphenesin with the pharmacy.

Loratadine + Ambroxol + Guaiphenesin is a generic medicine name and there are several brands available for it. Some of the brands for loratadine + ambroxol + guaiphenesin might be better known than loratadine + ambroxol + guaiphenesin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loratadine + ambroxol + guaiphenesin in stock, you can ask for one of the branded alternatives for loratadine + ambroxol + guaiphenesin.