- Medicine India
- Generic Medicines
- Pharmacology For Mometasone + Fusidic Acid + Clotrimazole
Mometasone + Fusidic Acid + Clotrimazole Pharmacology
Mometasone + Fusidic Acid + ClotrimazoleAbout Mometasone + Fusidic Acid + ClotrimazoleN/AMechanism of Action of Mometasone + Fusidic Acid + ClotrimazoleN/APharmacokinets of Mometasone + Fusidic Acid + ClotrimazoleN/AOnset of Action for Mometasone + Fusidic Acid + ClotrimazoleN/ADuration of Action for Mometasone + Fusidic Acid + ClotrimazoleN/AHalf Life of Mometasone + Fusidic Acid + ClotrimazoleN/ASide Effects of Mometasone + Fusidic Acid + ClotrimazoleN/AContra-indications of Mometasone + Fusidic Acid + ClotrimazoleN/ASpecial Precautions while taking Mometasone + Fusidic Acid + ClotrimazoleN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mometasone + Fusidic Acid + ClotrimazoleSkin infections and associated inflammation.Interactions for Mometasone + Fusidic Acid + ClotrimazoleN/ATypical Dosage for Mometasone + Fusidic Acid + ClotrimazoleN/ASchedule of Mometasone + Fusidic Acid + ClotrimazoleN/AStorage Requirements for Mometasone + Fusidic Acid + ClotrimazoleN/AEffects of Missed Dosage of Mometasone + Fusidic Acid + ClotrimazoleN/AEffects of Overdose of Mometasone + Fusidic Acid + ClotrimazoleN/A
MometasoneAbout MometasoneA glucocorticoid steroid, Anti psoriatic,anti asthma ,anti inflammatory.Mechanism of Action of MometasoneMometasone is a topical medium potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of MometasoneAbsorption: Mometasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier. Absorption is increased in inflammation, occlusion and skin damage.Onset of Action for MometasoneN/ADuration of Action for MometasoneN/AHalf Life of MometasoneN/ASide Effects of Mometasone1.Thinning of epidermis
5.Atrophy (Dermal changes)
11.Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
14.TinglingContra-indications of Mometasone1.Hypersensitivity to Mometasone and other corticosteroids
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Mometasone1.Avoid the use of medicament if irritation or hypersensitivity occurs
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7.Withdraw gradually after prolonged use
8.Use caution on areas where the skin creases, such as armpits, knees, and elbows
9.Avoid application on large surface areaPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Indications for Mometasone1.Otitis externa
3.Dermatoses (secondary infected)
8.Anal and vulval pruritisInteractions for MometasoneN/ATypical Dosage for MometasoneTopical: Mometasone Furoate 0.1 % cream, ointment or lotion is used.
Clean the affected area and wash with warm water and then dry. Apply 2 - 3 times daily for 2 weeks with gentle massage.
Schedule of MometasoneHStorage Requirements for MometasoneStore at room temperature. Protect from heat and light. Keep the container tightly closed. Keep out of the reach of childrenEffects of Missed Dosage of MometasoneApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MometasoneGive supportive measures and symptomatic treatment.
Fusidic acidAbout Fusidic acidA bacteriostatic Steroid Antibiotic, Systemic antibacterial, anti-infective.Mechanism of Action of Fusidic acidFusidic acid is a bactericidal or bacteriostatic drug depending upon the concentration. It inhibits the transfer of aminoacid from aminoacyl sRNA to the protein. This will leads to inhibition of protein synthesis in the bacteria and prevent the growth of microbes.Pharmacokinets of Fusidic acidAbsorption: It is very poorly absorbed after topical administration.Onset of Action for Fusidic acidNULL.Duration of Action for Fusidic acidNULL.Half Life of Fusidic acidN/ASide Effects of Fusidic acid1. Contact dermatitis
Contra-indications of Fusidic acid1. Hypersensitivity to Fusidic acidSpecial Precautions while taking Fusidic acid1. Avoid contact with eyes
2. If irritation occurs discard the use of medicament
3. Hepatic impairment
4. Monitor liver function test
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Fusidic acidPrimary and secondary skin infections
4. Sycosis barbae
Interactions for Fusidic acidNULL.Typical Dosage for Fusidic acidFusidic acid 2% cream or ointment .Clean and dry the affected area. Apply the drug as thin layer.2 - 4 times daily. Schedule of Fusidic acidN/AStorage Requirements for Fusidic acidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Fusidic acidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fusidic acidGive supportive measures and symptomatic treatment.
ClotrimazoleAbout ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.
Home Delivery for Mometasone + Fusidic Acid + Clotrimazole in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mometasone + fusidic acid + clotrimazole.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mometasone + fusidic acid + clotrimazole and other medicines and health products. Home delivery services for mometasone + fusidic acid + clotrimazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take mometasone + fusidic acid + clotrimazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mometasone + fusidic acid + clotrimazole before they complete the sale. You can get this information while placing the order for mometasone + fusidic acid + clotrimazole with the pharmacy.
Mometasone + Fusidic Acid + Clotrimazole is a generic medicine name and there are several brands available for it. Some of the brands for mometasone + fusidic acid + clotrimazole might be better known than mometasone + fusidic acid + clotrimazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mometasone + fusidic acid + clotrimazole in stock, you can ask for one of the branded alternatives for mometasone + fusidic acid + clotrimazole.