Lubiprostone Pharmacology


About Lubiprostone
Chloride channel activator, laxative.
Mechanism of Action of Lubiprostone
Lubiprostone, a locally acting chloride channel activator, activates CIC-2, a normal constituent of the luminal membrane of the human intestine, which enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium serum concentrations. By increasing intestinal fluid secretion, lubiprostone increases intestinal motility, which facilitates the passage of stool and alleviates symptoms associated with chronic idiopathic constipation.
Pharmacokinets of Lubiprostone
Absorption: Absorption after oral admin is negligible
Distribution:Protein binding is about 94%.
Metabolism: Rapidly and extensively metabolised by carbonyl reductase, likely in the stomach and jejunum.
Elimination: 60% in urine and 30% in feces.
Onset of Action for Lubiprostone
Duration of Action for Lubiprostone
Half Life of Lubiprostone
0.9 to 1.4 h.
Side Effects of Lubiprostone
3.Abdominal distension
4.Abdominal pain
11.Peripheral oedema
Contra-indications of Lubiprostone
1.History of mechanical GI obstruction
2.Hypersensitivity to any component of the product
Special Precautions while taking Lubiprostone
1.Not to be used in patients with severe diarrhoea.
Pregnancy Related Information
Old Age Related Information
My be used
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended
Indications for Lubiprostone
1.For the treatment of chronic idiopathic constipation in the adult population.
2.Treatment of irritable bowel syndrome with constipation in women who are 18 years of age or older.
Interactions for Lubiprostone
Typical Dosage for Lubiprostone
Chronic Idiopathic Constipation in Adults:oral;24 mcg twice daily.
Bowel Syndrome and Constipation in Adult Women:ora:l8 mcg twice daily with food or water.

Schedule of Lubiprostone
Storage Requirements for Lubiprostone
Oral: Store between 15-30?C.
Effects of Missed Dosage of Lubiprostone
Effects of Overdose of Lubiprostone

Home Delivery for Lubiprostone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lubiprostone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lubiprostone and other medicines and health products. Home delivery services for lubiprostone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lubiprostone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lubiprostone before they complete the sale. You can get this information while placing the order for lubiprostone with the pharmacy.

Lubiprostone is a generic medicine name and there are several brands available for it. Some of the brands for lubiprostone might be better known than lubiprostone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lubiprostone in stock, you can ask for one of the branded alternatives for lubiprostone.