Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate Pharmacology

Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate

About Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Mechanism of Action of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Pharmacokinets of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Onset of Action for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Duration of Action for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Half Life of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Side Effects of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Contra-indications of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Special Precautions while taking Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
1.Antioxidant
2.Nutritional supplement
Interactions for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Typical Dosage for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Schedule of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Storage Requirements for Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Effects of Missed Dosage of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Effects of Overdose of Beta Carotene +Lutein +Lycopene + Selenium + Vitamin E + Zinc Sulphate
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Beta Carotene

About Beta Carotene
A natural precursor to Vitamin A.
Mechanism of Action of Beta Carotene
Beta-carotene acts as the precursor of Vitamin A and in the body it is converted in to Vitamin A. Vitamin A is required for a variety of physiological functions in the body such as: - 1).Proper functioning of retina and formation of pigment Rhodopsin during dark adaptation. 2).promotes differentiation and maintains structural integrity of epithelia over the body and also retard the malignancies of epithelial structures.3).Promotes mucous secretion. 4).Inhibits keratinization, 5). Maintains proper bone growth, 6).Maintenance of spermatogenesis, 7).Supports foetal development, 8).Improves resistance to infection. It is required for proper antibody response, normal lymphocyte proliferation and killer cell function.
Pharmacokinets of Beta Carotene
Absorption: Completely absorbed normally. Steatorrhoea, bile deficiency, and protein poor diet adversely affects the absorption and absorption requires bile salts, pancreatic lipase, and dietary fat.
Distribution: Stored primarily as palmitate in kupffer`s cells in liver. Circulates in the form of specific alpha-1 protein; retinol binding protein and transported to cellular retinol binding protein of target cells.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and a small amount is excreted through urine.
Onset of Action for Beta Carotene
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Duration of Action for Beta Carotene
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Half Life of Beta Carotene
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Side Effects of Beta Carotene
Adverse effects occurs only with higher doses and toxicity
1. Nausea
2. Vomiting
3. Itching
4. Dermatitis
5. Exfoliation
6. Alopecia
7. Bone and joint pain
8. Anorexia
9. Irritability
10. Increased intracranial pressure
11. Hepatic impairment
12. Anaphylactic shock
Contra-indications of Beta Carotene
1. Hypervitaminosis A
2. Hypersensitivity to Beta Carotene
Special Precautions while taking Beta Carotene
1. Oral form should not use in patients with malabsorption syndrome.
2. In inadequate bile secretion oral route may be used with concurrent administration of bile salts.
3. I. V. route is contraindicated except for special water miscible forms intended for infusion with large parenteral volumes and should not use I. V. push of vitamin A of any type.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Beta Carotene
1. Vitamin A deficiency
2. Xerophthalmia
3. Acne
4. Ichthyosis
5. Bitot`s spots
6. Night blindness
Interactions for Beta Carotene
Cholestyramine: Absorption of Vitamin A is reduced due to reduced availability of fat stabilizing bile salts.
Mineral oil: Interferes with intestinal absorption of Vitamin A.
Oral Contraceptives: Plasma Vitamin A levels are significantly increased.
Typical Dosage for Beta Carotene
Severe vitamin A deficiency with xerophthalmia: 500000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Severe vitamin A deficiency: 100000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Children: 5000 to 10000 IU daily for 14 days.
Schedule of Beta Carotene
C1 (Oral)
C (Parenteral)
Storage Requirements for Beta Carotene
Store in a well closed, airtight container in a cool dry place.
Effects of Missed Dosage of Beta Carotene
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Beta Carotene
Discontinue the vitamin A if hypercalcaemia persists and administer I.V. saline, prednisolone, and calcitonin if required. Monitor hepatic function tests to detect liver damage.

Lutein

About Lutein
Carotenoid, Xanthophyll, Dietary antioxidant.
Mechanism of Action of Lutein
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Pharmacokinets of Lutein
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Onset of Action for Lutein
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Duration of Action for Lutein
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Half Life of Lutein
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Side Effects of Lutein
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Contra-indications of Lutein
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Special Precautions while taking Lutein
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Lutein
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Interactions for Lutein
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Typical Dosage for Lutein
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Schedule of Lutein
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Storage Requirements for Lutein
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Effects of Missed Dosage of Lutein
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Effects of Overdose of Lutein
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Lycopene

About Lycopene
Carotenoid;Terpenes and terpenoids, Dietary antioxidant.
Mechanism of Action of Lycopene
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Pharmacokinets of Lycopene
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Onset of Action for Lycopene
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Duration of Action for Lycopene
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Half Life of Lycopene
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Side Effects of Lycopene
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Contra-indications of Lycopene
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Special Precautions while taking Lycopene
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Lycopene
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Interactions for Lycopene
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Typical Dosage for Lycopene
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Schedule of Lycopene
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Storage Requirements for Lycopene
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Effects of Missed Dosage of Lycopene
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Effects of Overdose of Lycopene
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Selenium

About Selenium
A vital antioxidant, selenium acts with vitamin E to protect the immune system and maintain healthy heart function. It is needed for pancreatic function and tissue elasticity and has been shown to protect against radiation and toxic minerals. High levels of heart disease are associated with selenium-deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China. Best sources are butter, Brazil nuts, seafood and grains grown in selenium-rich soil.
Mechanism of Action of Selenium
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Pharmacokinets of Selenium
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Onset of Action for Selenium
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Duration of Action for Selenium
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Half Life of Selenium
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Side Effects of Selenium
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Contra-indications of Selenium
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Special Precautions while taking Selenium
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Selenium
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Interactions for Selenium
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Typical Dosage for Selenium
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Schedule of Selenium
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Storage Requirements for Selenium
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Effects of Missed Dosage of Selenium
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Effects of Overdose of Selenium
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Vitamin E

About Vitamin E
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Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
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Duration of Action for Vitamin E
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Half Life of Vitamin E
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Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
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Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

Zinc Sulphate

About Zinc Sulphate
Zinc compound, An astringent , Adjunctive treatment of Wilson?s disease.
Mechanism of Action of Zinc Sulphate
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Pharmacokinets of Zinc Sulphate
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Onset of Action for Zinc Sulphate
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Duration of Action for Zinc Sulphate
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Half Life of Zinc Sulphate
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Side Effects of Zinc Sulphate
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Contra-indications of Zinc Sulphate
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Special Precautions while taking Zinc Sulphate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Zinc Sulphate
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Interactions for Zinc Sulphate
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Typical Dosage for Zinc Sulphate
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Schedule of Zinc Sulphate
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Storage Requirements for Zinc Sulphate
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Effects of Missed Dosage of Zinc Sulphate
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Effects of Overdose of Zinc Sulphate
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